document

High-definition imaging of carotid artery wall dynamics

Kruizinga, P. (author), Mastik, Frits (author), van den Oord, Stijn C.H. (author), Schinkel, Arend F.L. (author), Bosch, Johannes G. (author), de Jong, N. (author), van Soest, G. (author), van der Steen, A.F.W. (author)

The carotid artery (CA) is central to cardiovascular research, because of the clinical relevance of CA plaques as culprits of stroke and the accessibility of the CA for cardiovascular screening. The viscoelastic state of this artery, essential for clinical evaluation, can be assessed by observing arterial deformation in response to the...

journal article 2014

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Acoustic Characterization of a 32 × 32 Element PZT-on-ASIC Matrix Transducer for 3D Transesophageal Echocardiography

Shabanimotlagh, M. (author), Raghunathan, S.B. (author), Bera, D. (author), Chen, Z. (author), Chen, C. (author), Daeichin, V. (author), Pertijs, M.A.P. (author), Bosch, J.G. (author), de Jong, N. (author), Verweij, M.D. (author)

Echocardiography is a portable, safe, and low-cost imaging technique for accurate assessment of the heart. In transesophageal echocardiography (TEE) the esophagus is utilized as the imaging window to examine the cardiac anatomy and function. In conventional TEE probes, a one-dimensional (1D) ultrasound array is employed to obtain two-dimensional...

abstract 2017

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Microbubble Composition and Preparation for High-Frequency Contrast-Enhanced Ultrasound Imaging: In Vitro and in Vivo Evaluation

Daeichin, Verya (author), van Rooij, Tom (author), Skachkov, Ilya (author), Ergin, Bulent (author), Specht, Patricia A.C. (author), Lima, Alexandre (author), Ince, Can (author), Bosch, Johan G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)

Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (>15 MHz) are available for contrast-enhanced ultrasound (CEUS) imaging. Moreover, the composition of the limited commercially available UCAs for high-frequency CEUS (hfCEUS) is...

journal article 2017

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Cardiac Shear Wave Velocity Detection in the Porcine Heart

Vos, H.J. (author), van Dalen, Bas M. (author), Heinonen, Ilkka (author), Bosch, Johan G. (author), Sorop, Oana (author), Duncker, Dirk J. (author), van der Steen, A.F.W. (author), de Jong, N. (author)

Cardiac muscle stiffness can potentially be estimated non-invasively with shear wave elastography. Shear waves are present on the septal wall after mitral and aortic valve closure, thus providing an opportunity to assess stiffness in early systole and early diastole. We report on the shear wave recordings of 22 minipigs with high-frame-rate...

journal article 2017

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A Front-End ASIC with Receive Sub-array Beamforming Integrated with a 32 × 32 PZT Matrix Transducer for 3-D Transesophageal Echocardiography

Chen, C. (author), Chen, Z. (author), Bera, Deep (author), Raghunathan, S.B. (author), Shabanimotlagh, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Ponte, Jacco (author), Prins, Christian (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)

This paper presents a power-and area-efficient front-end application-specific integrated circuit (ASIC) that is directly integrated with an array of 32 × 32 piezoelectric transducer elements to enable next-generation miniature ultrasound probes for real-time 3-D transesophageal echocardiography. The 6.1 × 6.1 mm² ASIC, implemented...

journal article 2017

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Cardiac Shear Wave Elastography Using a Clinical Ultrasound System

Strachinaru, Mihai (author), Bosch, Johan G. (author), van Dalen, Bas M. (author), van Gils, Lennart (author), van der Steen, A.F.W. (author), de Jong, N. (author), Geleijnse, Marcel L. (author), Vos, H.J. (author)

The propagation velocity of shear waves relates to tissue stiffness. We prove that a regular clinical cardiac ultrasound system can determine shear wave velocity with a conventional unmodified tissue Doppler imaging (TDI) application. The investigation was performed on five tissue phantoms with different stiffness using a research platform...

journal article 2017

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Compressive 3D ultrasound imaging using a single sensor

Kruizinga, P. (author), van der Meulen, P.F. (author), Fedjajevs, A. (author), Mastik, F (author), Springeling, Geert (author), de Jong, N. (author), Bosch, J.G. (author), Leus, G.J.T. (author)

Three-dimensional ultrasound is a powerful imaging technique, but it requires thousands of sensors and complex hardware. Very recently, the discovery of compressive sensing has shown that the signal structure can be exploited to reduce the burden posed by traditional sensing requirements. In this spirit, we have designed a simple ultrasound...

journal article 2017

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A Reconfigurable Ultrasound Transceiver ASIC With 24 x 40 Elements for 3-D Carotid Artery Imaging

Kang, E. (author), Ding, Q. (author), Shabanimotlagh, M. (author), Kruizinga, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, J.W. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)

This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) designed for 3-D ultrasonic imaging of the carotid artery. This application calls for an array of thousands of ultrasonic transducer elements, far exceeding the number of channels of conventional imaging systems. The 3.6 x 6.8 mm² ASIC...

journal article 2018

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Fast Volumetric Imaging Using a Matrix Transesophageal Echocardiography Probe with Partitioned Transmit–Receive Array

Bera, D. (author), Van Den Adel, Franc (author), Radeljic-Jakic, Nikola (author), Lippe, Boris (author), Soozande, M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Kruizinga, P. (author), Daeichin, V. (author), Vos, H.J. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author)

We describe a 3-D multiline parallel beamforming scheme for real-time volumetric ultrasound imaging using a prototype matrix transesophageal echocardiography probe with diagonally diced elements and separated transmit and receive arrays. The elements in the smaller rectangular transmit array are directly wired to the ultrasound system. The...

journal article 2018

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Multiline 3D beamforming using micro-beamformed datasets for pediatric transesophageal echocardiography

Bera, D. (author), Raghunathan, S.B. (author), Chen, C. (author), Chen, Z. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Daeichin, V. (author), Vos, H.J. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, J.G. (author)

Until now, no matrix transducer has been realized for 3D transesophageal echocardiography (TEE) in pediatric patients. In 3D TEE with a matrix transducer, the biggest challenges are to connect a large number of elements to a standard ultrasound system, and to achieve a high volume rate (>200 Hz). To address these issues, we have recently...

journal article 2018

document

Consensus molecular subtype classification of colorectal adenomas

Komor, Malgorzata A. (author), Bosch, Linda J.W. (author), Bounova, Gergana (author), Bolijn, Anne S. (author), Delis‐van Diemen, Pien M. (author), Rausch, Christian (author), Hoogstrate, Youri (author), Stubbs, Andrew P. (author), de Jong, Mark (author), Wessels, L.F.A. (author)

Consensus molecular subtyping is an RNA expression-based classification system for colorectal cancer (CRC). Genomic alterations accumulate during CRC pathogenesis, including the premalignant adenoma stage, leading to changes in RNA expression. Only a minority of adenomas progress to malignancies, a transition that is associated with specific...

journal article 2018

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A Pitch-Matched Front-End ASIC With Integrated Subarray Beamforming ADC for Miniature 3-D Ultrasound Probes

Chen, C. (author), Chen, Z. (author), Bera, Deep (author), Noothout, E.C. (author), Chang, Z.Y. (author), Tan, M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)

This paper presents a front-end application-specified integrated circuit (ASIC) integrated with a 2-D PZT matrix transducer that enables in-probe digitization with acceptable power dissipation for the next-generation endoscopic and catheter-based 3-D ultrasound imaging systems. To achieve power-efficient massively parallel analog-to-digital...

journal article 2018

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High Frame Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld, J.D. (author), Engelhard, S. (author), Vos, H.J. (author), Reijnen, M. (author), Gijsen, F.J.H. (author), Versluis, M. (author), Jebbink, E. Groot (author), de Jong, N. (author), Bosch, J. G. (author)

Treatment of abdominal aortic (AA) aneurysms and stenotic lesions may be improved by analyzing their associated blood flow patterns. Angle-independent blood flow patterns in the AA can be obtained by combining echo-particle image velocimetry (ePIV) with high frame rate contrast-enhanced ultrasonography. However, ePIV performance is affected...

journal article 2018

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Feasibility of High Frame Rate 3-D Intracardiac Echography using Fan-Beam Transmissions

Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Vos, H.J. (author), Bosch, J.G. (author), de Jong, N. (author)

poster 2019

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Reproducibility of Natural Shear Wave Elastography Measurements

Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Dan J. (author), Geleijnse, Marcel L. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author), Vos, H.J. (author)

For the quantification of myocardial function, myocardial stiffness can potentially be measured non-invasively using shear wave elastography. Clinical diagnosis requires high precision. In 10 healthy volunteers, we studied the reproducibility of the measurement of propagation speeds of shear waves induced by aortic and mitral valve closure ...

journal article 2019

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A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

Keijzer, Lana B.H. (author), Caenen, A.F.M. (author), Voorneveld, J.D. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Vos, H.J. (author)

Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve current diagnosis of heart failure. This study aims to bridge the knowledge gap between both techniques and discuss their respective impacts on cardiac stiffness evaluation. We recorded...

journal article 2020

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Impact of Bit Errors in Digitized RF Data on Ultrasound Image Quality

Chen, Z. (author), Soozande, M. (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)

This article quantitatively analyzes the impact of bit errors in digitized RF data on ultrasound image quality. The quality of B-mode images in both linear array and phased array imaging is evaluated by means of three objective image quality metrics: peak signal-to-noise ratio, structural similarity index, and contrast-to-noise ratio, when...

journal article 2020

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Receive/transmit aperture selection for 3D ultrasound imaging with a 2D matrix transducer

Mozaffarzadeh, M. (author), Soozande, M. (author), Fool, F. (author), Pertijs, M.A.P. (author), Vos, H.J. (author), Verweij, M.D. (author), Bosch, Johan G. (author), de Jong, N. (author)

Recently, we realized a prototype matrix transducer consisting of 48 rows of 80 elements on top of a tiled set of Application Specific Integrated Circuits (ASICs) implementing a row-level control connecting one transmit/receive channel to an arbitrary subset of elements per row. A fully sampled array data acquisition is implemented by a...

journal article 2020

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4-D Echo-Particle Image Velocimetry in a Left Ventricular Phantom

Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)

Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...

journal article 2020

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Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High Frame Rate EchoPIV in Patients

Voorneveld, J.D. (author), Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), Mutluer, Ferit O. (author), van der Steen, A.F.W. (author), Ten Cate, Folkert (author), de Jong, N. (author), Vos, H.J. (author), Van den Bosch, Annemien E. (author), Bosch, Johan G. (author)

High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion...

journal article 2021