Influence of Nanoparticle Coating on the Differential Magnetometry and Wireless Actuation of Biohybrid Microrobots

Magnetic nanoparticles can be electrostatically assembled around sperm cells to form biohybrid micro robots. These biohybrid microrobots possess sufficient magnetic material to potentially allow for pulse-echo localization and wireless actuation. Alternatively, magnetic excitation of these nanoparticles can be used for localization based on...

Quantification of heterogeneity as a biomarker in tumor imaging: A systematic review

BACKGROUND: Many techniques are proposed for the quantification of tumor heterogeneity as an imaging biomarker for differentiation between tumor types, tumor grading, response monitoring and outcome prediction. However, in clinical practice these methods are barely used. This study evaluates the reported performance of the described methods and...

Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: Image registration approach

Background Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...

Developing a tool for the validation of quantitative DCE-MRI

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to noninvasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology...

Multi-modal image registration: Matching MRI with histology