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Kim, S.H. (author), Park, J. (author), Joo, C. (author), Kim, D. (author), Ha, T. (author)
RecA proteins form a long stable filament on a single-stranded DNA and catalyze strand exchange reaction. The stability of RecA filament changes dramatically with pH, yet its detailed mechanism is not known. Here, using a single molecule assay, we determined the binding and dissociation rates of RecA monomers at the filament ends at various pH....
journal article 2015
document
Kim, SH (author), Joo, C. (author), Seong, A (author), Vafabakshsh, A (author), Botvinick, A (author), Berns, A (author), Palmer, TA (author), Wang, Z. (author), Ha, Seungkyu (author), Jakobsson, ME (author), Sun, M (author)
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without extracellular Ca2+, ER Ca2+ release is the source of intracellular Ca2+ oscillations induced...
journal article 2015
document
Kim, S.H. (author), Joo, C. (author), Ha, T. (author), Kim, D. (author)
A is a DNA-dependent ATPase and mediates homologous recombination by first forming a filament on a single-stranded (ss) DNA. RecA binds preferentially to TGG repeat sequence, which resembles the recombination hot spot Chi (5'-GCTGGTGG-3') and is the most frequent pattern (GTG) of the codon usage in Escherichia coli. Because of the highly dynamic...
journal article 2013
document
Kim, T.J. (author), Joo, C. (author), Seong, J. (author), Vafabakhsh, R. (author), Botvinick, E.L. (author), Berns, M.W. (author), Palmer, A.E. (author), Wang, N. (author), Ha, T. (author), Jakobsson, E. (author), Sun, J. (author), Wang, Y. (author)
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without extracellular Ca2+, ER Ca2+ release is the source of intracellular Ca2+ oscillations induced...
journal article 2015
document
Kim, B. (author), Ha, M. (author), Loeff, L. (author), Chang, H. (author), Simanshu, D.K. (author), Li, S. (author), Fareh, M. (author), Patel, D.J. (author), Joo, C. (author), Kim, V.N. (author)
Terminal uridylyl transferases (TUTs) function as integral regulators of microRNA (miRNA) biogenesis. Using biochemistry, single-molecule, and deep sequencing techniques, we here investigate the mechanism by which human TUT7 (also known as ZCCHC6) recognizes and uridylates precursor miRNAs (pre-miRNAs) in the absence of Lin28. We find that the...
journal article 2015
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