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Luan, Ying (author), Renaud, Guillaume (author), Raymond, Jason L. (author), Segers, Tim (author), Lajoinie, Guillaume (author), Beurskens, Robert (author), Mastik, Frits (author), Kokhuis, Tom J A (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)
In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a...
journal article 2016
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Beekers, D.I. (author), Vegter, Merel (author), Lattwein, Kirby R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound insonification of microbubbles can locally increase vascular permeability to enhance drug delivery. To control and optimize the therapeutic potential, we need to better understand the underlying biological mechanisms of the drug delivery pathways. The aim of this in vitro study was to elucidate the microbubble-endothelial cell...
journal article 2020
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Beekers, D.I. (author), Mastik, Frits (author), Beurskens, Robert (author), Tang, Phoei Ying (author), Vegter, Merel (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound insonification of microbubbles can locally enhance drug delivery, but the microbubble–cell interaction remains poorly understood. Because intracellular calcium (Ca<sub>i</sub> <sup>2+</sup>) is a key cellular regulator, unraveling the Ca<sub>i</sub> <sup>2+</sup> fluctuations caused by an oscillating microbubble provides crucial...
journal article 2020
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Beekers, D.I. (author), Lattwein, Kirby R. (author), Kouijzer, Joop J.P. (author), Langeveld, Simone A.G. (author), Vegter, M. (author), Beurskens, Robert (author), Mastik, F. (author), Verduyn Lunel, Rogier (author), van der Steen, A.F.W. (author), de Jong, N. (author)
Controlling microbubble-mediated drug delivery requires the underlying biological and physical mechanisms to be unraveled. To image both microbubble oscillation upon ultrasound insonification and the resulting cellular response, we developed an optical imaging system that can achieve the necessary nanosecond temporal and nanometer spatial...
journal article 2019
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Li, H. (author), Li, X. (author), Collado Lara, G. (author), Lattwein, K.R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), Verweij, M.A. (author), de Jong, N. (author), Kooiman, Klazina (author)
Ultrasound contrast-mediated medical imaging and therapy both rely on the dynamics of micron- and nanometer-sized ultrasound cavitation nuclei, such as phospholipid-coated microbubbles and phase-change droplets. Ultrasound cavitation nuclei respond non-linearly to ultrasound on a nanosecond time scale that necessitates the use of ultra-high...
journal article 2023
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Janjic, Jovana (author), Tan, M. (author), Daeichin, V. (author), Noothout, E.C. (author), Chen, C. (author), Chen, Z. (author), Chang, Z.Y. (author), Beurskens, Robert H.S.H. (author), van Soest, G. (author), van der Steen, A.F.W. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author), de Jong, N. (author)
Intravascular ultrasound is an imaging modality used to visualize atherosclerosis from within the inner lumen of human arteries. Complex lesions like chronic total occlusions require forward-looking intravascular ultrasound (FL-IVUS), instead of the conventional side-looking geometry. Volumetric imaging can be achieved with 2D array...
journal article 2018
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