Expanding the family of genetically encoded voltage indicators with a candidate Heliorhodopsin exhibiting near-infrared fluorescence

Genetically encoded voltage indicators, particularly those based on microbial rhodopsins, are gaining traction in neuroscience as fluorescent sensors for imaging voltage dynamics with high-spatiotemporal precision. Here we establish a novel genetically encoded voltage indicator candidate based on the recently discovered subfamily of the...

Robust contour propagation using deep learning and image registration for online adaptive proton therapy of prostate cancer

Purpose: To develop and validate a robust and accurate registration pipeline for automatic contour propagation for online adaptive Intensity-Modulated Proton Therapy (IMPT) of prostate cancer using elastix software and deep learning. Methods: A three-dimensional (3D) Convolutional Neural Network was trained for automatic bladder segmentation...

Correlations between the shifts in prompt gamma emission profiles and the changes in daily target coverage during simulated pencil beam scanning proton therapy

The aim of this study was to investigate the feasibility of using prompt gamma (PG) ray emission profiles to monitor changes in dose to the planning target volume (PTV) during pencil beam scanning (PBS) proton therapy as a result of day-to-day variation in patient anatomy.
 For 11 prostate patients, we simulated treatment plan delivery...

Evaluation of an Open Source Registration Package for Automatic Contour Propagation in Online Adaptive Intensity-Modulated Proton Therapy of Prostate Cancer

Objective: Our goal was to investigate the performance of an open source deformable image registration package, elastix, for fast and robust contour propagation in the context of online-adaptive intensity-modulated proton therapy (IMPT) for prostate cancer. Methods: A planning and 7–10 repeat CT scans were available of 18 prostate cancer...

Revision of the family Gastrodoridae (Crustacea, Decapoda), with description of the first species from The Cretaceous

Representatives of the family Gastrodoridae were exclusively known from Jurassic deposits in central Europe. Here, the first Cretaceous species, Gastrodorus cretahispanicus n. sp., is recorded from reefal strata of the Eguino Formation (Albeniz Unit) of Albian-Cenomanian age, in western Navarra (northern Spain). Not only does the occurrence of...

Etyid crabs (Crustacea, Decapoda) from mid-cretaceous reefal strata of Navarra, Northern Spain

All known etyid crabs (Crustacea, Decapoda) from the upper Albian – lower Cenomanian Aldoirar coralgal-dominated patch reef (Albeniz Unit, Eguino Formation), as exposed at the disused Koskobilo quarry in Navarra, northern Spain, are described, discussed and illustrated. A new species, Xanthosia koskobiloensis, the first member of the genus on...

Late Campanian ammonites from the Saiwan area (Huqf Desert, Sultanate of Oman)

A late Cretaceous theropod caudal vertebra from the Sultanate of Oman

A caudal vertebra collected from conglomerates of the Al-Khod Formation (Late Cretaceous) in the Al-Khod area, Sultanate of Oman, is assigned to a medium-sized theropod dinosaur. The Al-Khod discovery represents one of the very few dinosaur records from the Middle East.

Computations of second order wave drift forces acting on a slowly oscillating object in 2D