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(1 - 11 of 11)
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Wang, G. (author), Zhao, Junfei (author), Haringa, C. (author), Tang, W. (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Deshmukh, A.T. (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Noorman, H.J. (author)
large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these substrate gradients at laboratory-scale continuous cultures. The IFR was applied to...
journal article 2018
document
Lu, Hongzhong (author), Cao, Weiqiang (author), Liu, X. (author), Sui, Yufei (author), Ouyang, Liming (author), Xia, Jianye (author), Huang, Mingzhi (author), Zhuang, Yingping (author), Zhang, Siliang (author), Noorman, H.J. (author), Chu, Ju (author)
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of A. niger was studied using multi-omics integrated analysis based on the latest GEMs ...
journal article 2018
document
Zhang, Y. (author), de Visser, C.C. (author), Chu, Q. (author)
Safe flight-envelope prediction is essential for preventing aircraft loss of control after the occurrence of sudden structural damage and aerodynamic failures. Considering the unpredictable nature of such failures, many challenges remain in the process of implementing such a prediction system. In this paper, an approach to online safe flight...
journal article 2018
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Zhang, Y. (author), de Visser, C.C. (author), Chu, Q. P. (author)
This paper reports the latest progress in the development of a database-driven safe flight envelope prediction system. By building up a database containing safe flight envelopes of different damage and fault scenarios, the challenges associated with online flight envelope prediction can be circumvented. The database is designed for different...
conference paper 2018
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Nabi, H.N. (author), Lombaerts, T.J.J. (author), Zhang, Y. (author), van Kampen, E. (author), Chu, Q. P. (author), de Visser, C.C. (author)
The research presented in this paper focuses on the effects of structural failures on the safe flight envelope of an aircraft, which is the set of all the states in which safe maneuver of the aircraft can be assured. Nonlinear reachability analysis basedonan optimal control formulation is performed to estimate the safe flight envelope using...
journal article 2018
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Shuang, Weifang (author), Zhang, S. (author), Wu, Xue (author), van Kampen, E. (author), Chu, Q. (author)

conference paper 2017
document
Chen, Liangbiao (author), Zhou, Jiang (author), Chu, Hsing-Wei (author), Zhang, G.Q. (author), Fan, Xuejun (author)
While moisture diffusion in microelectronic device and packaging has been studied for decades, the problems involving complex nonlinear moisture diffusion in multi-material assembly have not been fully studied. This paper has developed a general nonlinear diffusion model by adopting water activity, a continuous state variable, as the field...
journal article 2017
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Zhang, Y. (author), de Visser, C.C. (author), Chu, Q. P. (author)
conference paper 2016
document
Zhang, Y. (author), de Visser, C.C. (author), Chu, Q. P. (author)
conference paper 2016
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Zhang, Y. (author), de Visser, C.C. (author), Chu, Q. P. (author)
conference paper 2016
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Lu, Hongzhong (author), Liu, X. (author), Huang, Mingzhi (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Noorman, H.J. (author)
Background: Aspergillus niger is widely used for enzyme production and achievement of high enzyme production depends on the comprehensive understanding of cell's metabolic regulation mechanisms. Results: In this paper, we investigate the metabolic differences and regulation mechanisms between a high glucoamylase-producing strain A. niger...
journal article 2015
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