Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need...

Normative brain volumetry derived from different reference populations: impact on single-subject diagnostic assessment in dementia

Brain imaging data are increasingly made publicly accessible, and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient's base population, nor are imaging parameters such as field...

Can DCE-MRI explain the heterogeneity in radiopeptide uptake imaged by SPECT in a pancreatic neuroendocrine tumor model?

Although efficient delivery and distribution of treatment agents over the whole tumor is essential for successful tumor treatment, the distribution of most of these agents cannot be visualized. However, with single-photon emission computed tomography (SPECT), both delivery and uptake of radiolabeled peptides can be visualized in a neuroendocrine...

Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: Image registration approach

Background Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...

Developing a tool for the validation of quantitative DCE-MRI

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to noninvasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology...

Multi-modal image registration: Matching MRI with histology