Application and assessment of experimental methods to study the cytosolic primary metabolism of yeast

Although a large part of the metabolism of the yeast Saccharomyces cerevisiae, has been clarified, there are a number of issues that still limit the predictive power of metabolic models for this organism. The dissertation aims to improve the collection of data for metabolic models through application and assessment of different experimental...

Metabolic modeling of denitrification in Agrobacterium tumefaciens: A tool to study inhibiting and activating compounds for the denitrification pathway

A metabolic network model for facultative denitrification was developed based on experimental data obtained with Agrobacterium tumefaciens. The model includes kinetic regulation at the enzyme level and transcription regulation at the enzyme synthesis level. The objective of this work was to study the key factors regulating the metabolic response...

Metabolic modeling of denitrification in Agrobacterium tumefaciens: A tool to study inhibiting and activating compounds for the denitrification pathway