The interplay between polymerase organization and nucleosome occupancy along DNA: How dynamic roadblocks on the DNA induce the formation of RNA polymerase pelotons

During transcription RNA polymerase (RNAP) moves along a DNA molecule to copy the information on the DNA to an RNA molecule. Many textbook pictures show an RNAP sliding along empty DNA, but in reality it is crowded on the DNA and RNAP competes for space with many proteins such as other RNAP’s and histones. Coverage of DNA by histones is...