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Mügge, Carolin (author), Heine, Thomas (author), Baraibar, Alvaro Gomez (author), van Berkel, Willem J.H. (author), Paul, C.E. (author), Tischler, Dirk (author)
Amino groups derived from naturally abundant amino acids or (di)amines can be used as “shuttles” in nature for oxygen transfer to provide intermediates or products comprising N-O functional groups such as N-hydroxy, oxazine, isoxazolidine, nitro, nitrone, oxime, C-, S-, or N-nitroso, and azoxy units. To this end, molecular oxygen is activated...
review 2020
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Weusthuis, Ruud A. (author), Folch, Pauline L. (author), Pozo-Rodríguez, Ana (author), Paul, C.E. (author)
Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via...
review 2020
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Hollmann, F. (author), Opperman, Diederik J. (author), Paul, C.E. (author)
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we...
review 2020
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Hanefeld, U. (author), Hollmann, F. (author), Paul, C.E. (author)
Biocatalysis has an enormous impact on chemical synthesis. The waves in which biocatalysis has developed, and in doing so changed our perception of what organic chemistry is, were reviewed 20 and 10 years ago. Here we review the consequences of these waves of development. Nowadays, hydrolases are widely used on an industrial scale for the...
review 2022
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de Gonzalo, Gonzalo (author), Paul, C.E. (author)
Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions and have been increasingly incorporated as biocatalysts in scaled-up industrial processes for the production of valuable chiral compounds under mild and environmentally friendly conditions. In this review, we discuss...
review 2021
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Paul, Suvash Chandra (author), Mbewe, Peter B. K. (author), Kong, Sih Ying (author), Šavija, B. (author)
Concrete production utilizes cement as its major ingredient. Cement production is an important consumer of natural resources and energy. Furthermore, the cement industry is a significant CO2 producer. To reduce the environmental impact of concrete production, supplementary cementitious materials such as fly ash, blast furnace slag, and silica...
review 2019
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Gotor-Fernández, Vicente (author), Paul, C.E. (author)
Deep eutectic solvents (DES) are a class of neoteric solvents used in multiple applications amongst which biocatalytic processes. Due to its simple preparation, low cost and inherent biodegradable properties, its use as a non-volatile biocompatible co-solvent with both whole cells and isolated enzymes has displayed increased enzyme activity...
review 2019
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Guarneri, A. (author), van Berkel, Willem JH (author), Paul, C.E. (author)
Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in...
review 2019
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Berthier, Etienne (author), Floriciou, Dana (author), Gardner, Alex (author), Gourmelen, Noel (author), Jakob, Livia (author), Paul, Frank (author), Treichler, Désirée (author), Wouters, B. (author), Belart, Joaquín M C (author)
Glaciers distinct from the Greenland and Antarctic ice sheets are currently losing mass rapidly with direct and severe impacts on the habitability of some regions on Earth as glacier meltwater contributes to sea-level rise and alters regional water resources in arid regions. In this review, we present the different techniques developed during...
review 2023
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Paul, C.E. (author), Eggerichs, Daniel (author), Westphal, Adrie H. (author), Tischler, Dirk (author), van Berkel, Willem J.H. (author)
Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. In this review, we describe how FPMOs have evolved from model enzymes in mechanistic flavoprotein research to biotechnologically relevant catalysts that can be applied for...
review 2021
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