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Michaut, M (author), Chin, SF (author), Majewski, I (author), Severson, TM (author), Bismeijer, T (author), de Koning, L (author), Peeters, JK (author), Schouten, PC (author), Rueda, OM (author), Bosma, AJ (author), Wessels, L.F.A. (author)Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular processes that drive the development of ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and...journal article 2016
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Severson, Tesa M. (author), Wolf, Denise M. (author), Yau, Christina (author), Peeters, Justine (author), Wehkam, Diederik (author), Schouten, Philip C. (author), Chin, Suet-Feung (author), Majewski, Ian J. (author), Michaut, Magali (author), Bosma, Astrid (author), Pereira, Bernard (author), Bismeijer, Tycho (author), Wessels, L.F.A. (author), Caldas, Carlos (author), Bernards, Rene (author), Simon, Iris M. (author), Glas, Annuska M. (author), Linn, Sabine C. (author), van 't Veer, Laura (author)Background: Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like tumors. We hypothesized that these tumors may also be more sensitive to PARP inhibitors than standard treatments. Methods:...journal article 2017