Iron–sulfur clusters as inhibitors and catalysts of viral replication

A virus hijacks host cellular machineries and metabolites in order to reproduce. In response, the innate immune system activates different processes to fight back. Although many aspects of these processes have been well investigated, the key roles played by iron–sulfur [FeS] clusters, which are among the oldest classes of bio-inorganic...

EPOS-NL is the Dutch solid earth science infrastructure for research on georesources and geohazards

The European Plate Observing System - Netherlands (EPOS-NL) is the Dutch research infrastructure for solid Earth sciences. EPOS-NL is a cluster of large-scale geophysical facilities for research on georesources and geohazards. It is a partnership between Delft University of Technology (TU Delft), the Royal Netherlands Meteorological Institute...

Seismic inversion of soil damping and stiffness using multichannel analysis of surface wave measurements in the marine environment

Determination of soil material damping is known to be difficult and uncertain, especially in the offshore environment. Using an advanced inversion methodology based on multichannel spectral analysis, Scholte and Love wave measurements are used to characterize subsea soil from a North Sea site. After normalization, a determinant-based objective...

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical...

Charge-State Conditional Operation of a Spin Qubit

We report coherent operation of a singlet-triplet qubit controlled by the spatial arrangement of two confined electrons in an adjacent double quantum dot that is electrostatically coupled to the qubit. This four-dot system is the specific device geometry needed for two-qubit operations of a two-electron spin qubit. We extract the strength of the...

Training and learning for crisis management using a virtual simulation/gaming environment

Recent advances in computers, networking, and telecommunications offer new opportunities for using simulation and gaming as methodological tools for improving crisis management. It has become easy to develop virtual environments to support games, to have players at distributed workstations interacting with each other, to have automated...

A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the Proliferation, Immune response and RNA splicing modules in breast cancer