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Wang, G. (author), Zhao, Junfei (author), Haringa, C. (author), Tang, W. (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Deshmukh, A.T. (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Noorman, H.J. (author)
In a 54 m<sup>3</sup> large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these substrate gradients at laboratory-scale continuous cultures. The IFR was applied to...
journal article 2018
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Haringa, C. (author), Tang, W. (author), Wang, G. (author), Deshmukh, A.T. (author), van Winden, Wouter A. (author), Chu, Ju (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Mudde, R.F. (author), Noorman, H.J. (author)
We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodynamic-metabolic modeling can be utilized in 5 steps. (1) A model response study with a fixed...
journal article 2018