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Wu, Fabai (author), Japaridze, A. (author), Zheng, X.Z. (author), Wiktor, J.M. (author), Kerssemakers, J.W.J. (author), Dekker, C. (author)
Although the physical properties of chromosomes, including their morphology, mechanics, and dynamics are crucial for their biological function, many basic questions remain unresolved. Here we directly image the circular chromosome in live E. coli with a broadened cell shape. We find that it exhibits a torus topology with, on average, a lower...
journal article 2019
document
Wu, F. (author), Halatek, Jacob (author), Reiter, Matthias (author), Kingma, Enzo (author), Frey, Erwin (author), Dekker, C. (author)
Cells owe their internal organization to self-organized protein patterns, which originate and adapt to growth and external stimuli via a process that is as complex as it is little understood. Here, we study the emergence, stability, and state transitions of multistable Min protein oscillation patterns in live Escherichia coli bacteria during...
journal article 2016
document
Wu, F. (author), Dekker, C. (author)
Nanofabricated structures and microfluidic technologies are increasingly being used to study bacteria because of their precise spatial and temporal control. They have facilitated studying many long-standing questions regarding growth, chemotaxis and cell-fate switching, and opened up new areas such as probing the effect of boundary geometries...
review 2016
document
Männik, J. (author), Wu, F. (author), Hol, F.J.H. (author), Bisicchia, P. (author), Sherratt, D.J. (author), Keymer, J.E. (author), Dekker, C. (author)
Cell division in typical rod-shaped bacteria such as Escherichia coli shows a remarkable plasticity in being able to adapt to a variety of irregular cell shapes. Here, we investigate the roles of the Min system and the nucleoid-occlusion factor SlmA in supporting this adaptation. We study “squeezed” E. coli in narrow nanofabricated channels...
journal article 2012
document
Van den Hout, M. (author), Hall, A.R. (author), Wu, M.Y. (author), Zandbergen, H.W. (author), Dekker, C. (author), Dekker, N.H. (author)
Solid-state nanopores are considered a promising tool for the study of biological polymers such as DNA and RNA, due largely to their flexibility in size, potential in device integration and robustness. Here, we show that the precise shape of small nanopores (?5 nm diameter in 20 nm SiN membranes) can be controlled by using transmission electron...
journal article 2010
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Smeets, R.M.M. (author), Keyser, U.F. (author), Wu, M.Y. (author), Dekker, N.H. (author), Dekker, C. (author)
journal article 2006
document
Tans, S.J. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
document
Dekker, C. (author), Tans, S.J. (author), Geerligs, L.J. (author), Bezryadin, A. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
document
Tans, S.J. (author), Miedema, R. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
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