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van Gulik, W.M. (author), Canelas, A (author), Nikerel, I.E. (author), Douma, RD (author), de Jonge, L.P. (author), Heijnen, J.J. (author)Obtaining meaningful snapshots of the metabolome of microorganisms requires rapid sampling and immediate quenching of all metabolic activity, to prevent any changes in metabolite levels after sampling. Furthermore, a suitable extraction method is required ensuring complete extraction of metabolites from the cells and inactivation of enzymatic...book chapter 2022
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Douma, L.A.N.R. (author)Mudstones play an important role in hydrocarbon exploration and production, carbon capture and storage, and nuclear waste disposal. The high concentration of clay minerals contribute to the high intrinsic anisotropy (e.g., velocity, strength, permeability, and resistivity changes with direction) of mudstones. This high anisotropy complicates,...doctoral thesis 2020
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Boersma, Q.D. (author), Douma, L.A.N.R. (author), Bertotti, G. (author), Barnhoorn, A. (author)In layered materials, the deformation style, orientation, confinement, and 3D connectivity of natural fractures is generally impacted by changes in sedimentary facies and alternations in mechanical properties. In this study we address this effect and perform a numerical sensitivity analysis. Mechanical properties, confining pressures, and...journal article 2020
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Zotz-Wilson, R.D. (author), Douma, L.A.N.R. (author), Sarout, Joel (author), Dautriat, Jeremie (author), Dewhurst, David (author), Barnhoorn, A. (author)Using active ultrasonic source survey data, coda wave decorrelation (CWD) time-lapse imaging during the triaxial compression of Whitby Mudstone cores provides a 3-D description of the evolution and redistribution of inelastic strain concentrations. Acoustic emissions (AEs) monitoring is also performed between any two consecutive surveys. From...journal article 2020
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- Barnhoorn, A. (author), Bakker, R.R. (author), Douma, L.A.N.R. (author), Pluymakers, Anne (author), Bertotti, G. (author) poster 2019
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Staring, M. (author), Pereira, Roberto (author), Douma, Huub (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)We have developed an adaptive double-focusing method that is specifically designed for the field-data application of source-receiver Marchenko redatuming. Typically, the single-focusing Marchenko method is combined with a multidimensional deconvolution (MDD) to achieve redatuming. Our method replaces the MDD step by a second focusing step...journal article 2018
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Staring, M. (author), Pereira, Roberto (author), Douma, Huub (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)In this paper, we focus on the field data application of source-receiver Marchenko redatuming. Conventionally, a source-receiver redatumed reflection response is obtained by first applying the Marchenko method for receiver-redatuming and then performing a multi-dimensional deconvolution (MDD) for sourceredatuming (Wapenaar et al. (2014)). The...abstract 2017
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Staring, M. (author), Pereira, R (author), Douma, H (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)We present an adaptive double-focusing method for applying source-receiver Marchenko redatuming to field data. Receiver redatuming is achieved by a first focusing step, where the coupled Marchenko equations are iteratively solved for the oneway Green’s functions. Next, source redatuming is typically performed by a multi-dimensional deconvolution...conference paper 2017
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Douma, Johanna G. (author), Volkers, Karin M. (author), Engels, Gwenda (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, Erik J.A. (author)Background: Despite the detrimental effects of physical inactivity for older adults, especially aged residents of residential care settings may spend much time in inactive behavior. This may be partly due to their poorer physical condition; however, there may also be other, setting-related factors that influence the amount of inactivity. The...journal article 2017
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Douma, J.G. (author), Volkers, K.M. (author), Vuijk, J.P. (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, E.J.A. (author)Background The number of older adults with dementia is expected to increase. Dementia is not only characterized by a decline in cognition, also other functions, for example, physical functioning change. A possible means to decrease the decline in these functions, or even improve them, could be increasing the amount of physical activity. A...journal article 2015
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Douma, Johanna G. (author), Volkers, Karin M. (author), Vuijk, Jelle Pieter (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, Erik J.A. (author)Background: The number of older adults with dementia is expected to increase. Dementia is not only characterized by a decline in cognition, also other functions, for example, physical functioning change. A possible means to decrease the decline in these functions, or even improve them, could be increasing the amount of physical activity. A...journal article 2015
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- Douma, Y.Y. (author) master thesis 2014
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- Douma, Y.Y. (author) report 2014
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- Douma, Y.Y. (author) master thesis 2014
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Wapenaar, C.P.A. (author), Douma, H. (author)The generalized optical theorem is an integral relation for the angle-dependent scattering amplitude of an inhomogeneous scattering object embedded in a homogeneous background. It has been derived separately for several scalar and vectorial wave phenomena. Here a unified optical theorem is derived that encompasses the separate versions for...journal article 2012
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De Jonge, L.P. (author), Douma, R.D. (author), Heijnen, J.J. (author), Van Gulik, W.M. (author)A sampling procedure for quantitative metabolomics in Penicillium chrysogenum based on cold aqueous methanol quenching was re-evaluated and optimized to reduce metabolite leakage during sample treatment. The optimization study included amino acids and intermediates of the glycolysis and the TCA-cycle. Metabolite leakage was found to be minimal...journal article 2011
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Douma, R.D. (author), Batista, J.M. (author), Touw, K.M. (author), Kiel, J.A.K.W. (author), Krikken, A.M. (author), Zhao, Z. (author), Veiga, T. (author), Klaassen, P. (author), Bovenberg, R.A.L. (author), Daran, J.M. (author), Heijnen, J.J. (author), Van Gulik, W.M. (author)Background In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observed. In this study a systems biology approach, monitoring changes from gene to produced flux, was used to study degeneration of...journal article 2011
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Regulation, transport aspects and degeneration of penicillin biosynthesis in Penicillium chrysogenumDouma, R.D. (author)Penicillin has been produced on an industrial scale for several decades. The improvements in its production process, in terms of product yields and production rates, present an unprecedented success in fermentation technology. However, the obtained product yields still remain far from their theoretical maximum. More insight in the regulation of...doctoral thesis 2010
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Gidijala, L. (author), Kiel, J.A.K.W. (author), Douma, R.D. (author), Seifar, R.M. (author), Van Gulik, W.M. (author), Bovenberg, R.A.L. (author), Veenhuis, M. (author), Van Klei, I.J. (author)This study aimed at developing an alternative host for the production of penicillin (PEN). As yet, the industrial production of this β-lactam antibiotic is confined to the filamentous fungus Penicillium chrysogenum. As such, the yeast Hansenula polymorpha, a recognized producer of pharmaceuticals, represents an attractive alternative....journal article 2009
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- Douma, S.G. (author) doctoral thesis 2006
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