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Schrauwen, J.T.C. (author), Karanasos, A. (author), Van Ditzhuijzen, N.S. (author), Aben, J.P. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)
Wall shear stress (WSS) plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is...
journal article 2015
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Nieuwstadt, H.A. (author), Kassar, Z.A.M. (author), Van der Lugt, A. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)
Background The benefits of a decreased slice thickness and/or in-plane voxel size in carotid MRI for atherosclerotic plaque component quantification accuracy and biomechanical peak cap stress analysis have not yet been investigated in detail because of practical limitations. Methods In order to provide a methodology that allows such an...
journal article 2015
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Kruizinga, P. (author), Springeling, G. (author), Van Soest, G. (author), Van der Steen, A.F.W. (author), De Jong, N. (author), Robertus, J.L. (author), Van der Lugt, A. (author)
We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection of lipid-rich atherosclerotic lesions. A common human carotid artery was obtained at autopsy, embedded in a neck mimicking phantom and imaged with a multimodality imaging system using interstitial illumination. Light was delivered through a 1.25-mm...
journal article 2014
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Nieuwstadt, H.A. (author), Van der Lugt, A. (author), Kassar, Z.A.M. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Gijsen, F.J.H. (author)
Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e., contrast below the noise level) and thus...
journal article 2014
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Jansen, K. (author), Van Soest, G. (author), Van der Steen, A.F.W. (author)
The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute coronary events. Even though the exact origins of plaque vulnerability remain elusive, the thin-cap fibroatheroma, characterized by a lipid-rich necrotic core covered by a thin fibrous cap, is considered to be the most prominent type of vulnerable plaque...
journal article 2014
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Maresca, D. (author), Adams, S. (author), Maresca, B. (author), Van der Steen, A.F.W. (author)
Intravascular ultrasound is a catheter-based imaging modality that was developed to investigate the condition of coronary arteries and assess the vulnerability of coronary atherosclerotic plaques in particular. Since its introduction in the clinic 20 years ago, use of intravascular ultrasound innovation has been relatively limited. Intravascular...
journal article 2014
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Gnanadesigan, M. (author), Van Soest, G. (author), White, S. (author), Scoltock, S. (author), Ughi, G.J. (author), Baumbach, A. (author), Van der Steen, A.F.W. (author), Regar, E. (author), Johnson, T.W. (author)
Atherosclerotic plaque composition can be imaged using the optical attenuation coefficient derived from intravascular optical coherence tomography (OCT) data. The relation between optical properties and tissue type has been established on autopsy tissues. In this study, we validate an ex-vivo model for the effect of temperature and tissue...
journal article 2014
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Jansen, K. (author), Wu, M. (author), Van der Steen, A.F.W. (author), Van Soest, G. (author)
Spectroscopic intravascular photoacoustic imaging (sIVPA) has shown promise to detect and distinguish lipids in atherosclerotic plaques. sIVPA generally utilizes one of the two high absorption bands in the lipid absorption spectrum at 1.2 ?m and 1.7 ?m. Specific absorption signatures of various lipid compounds within the bands in either...
journal article 2014
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Jansen, K. (author), Van der Steen, A.F.W. (author), Wu, M. (author), Van Beusekom, H.M.M. (author), Springeling, G. (author), Li, X. (author), Zhou, Q. (author), Shung, K.K. (author), De Kleijn, D.P.V. (author), Van Soest, G. (author)
The natural history of atherosclerosis is marked by changes in the lipid biochemistry in the diseased arterial wall. As lesions become more vulnerable, different cholesterol species accumulate in the plaque. Understanding unstable atherosclerosis as a pharmacological and interventional therapeutic target requires chemically specific imaging of...
journal article 2014
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Jansen, K. (author), Wu, M. (author), Van der Steen, A.F.W. (author), Van Soest, G. (author)
The presence of lipids in atherosclerotic coronary lesions is an important determinant of their potential to trigger acute coronary events. Spectroscopic intravascular photoacoustic imaging (sIVPA) has the potential to automatically detect lipids in atherosclerotic lesions. For realtime in vivo imaging, limiting the number of excitation...
journal article 2013
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Maresca, D. (author), Jansen, K. (author), Renaud, G. (author), Van Soest, G. (author), Li, X. (author), Zhou, Q. (author), De Jong, N. (author), Shung, K.K. (author), Van der Steen, A.F.W. (author)
We demonstrate the feasibility of intravascular ultrasound (IVUS) chirp imaging as well as chirp reversal ultrasound contrast imaging at intravascular ultrasound frequency. Chirp excitations were emitted with a 34?MHz single crystal intravascular transducer and compared to conventional Gaussian-shaped pulses of equal acoustic pressure. The...
journal article 2012
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Van Neer, P.L.M.J. (author), Danilouchkine, M.G. (author), Verweij, M.D. (author), Demi, L. (author), Voormolen, M.M. (author), Van der Steen, A.F.W. (author), De Jong, N. (author)
In medical ultrasound, fundamental imaging (FI) uses the reflected echoes from the same spectral band as that of the emitted pulse. The transmission frequency determines the trade-off between penetration depth and spatial resolution. Tissue harmonic imaging (THI) employs the second harmonic of the emitted frequency band to construct images....
journal article 2011
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Akyildiz, A.C. (author), Speelman, L. (author), Van Brummelen, H. (author), GutiƩrrez, M.A. (author), Virmani, R. (author), Van der Lugt, A. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)
Background: Rupture of the cap of a vulnerable plaque present in a coronary vessel may cause myocardial infarction and death. Cap rupture occurs when the peak cap stress exceeds the cap strength. The mechanical stress within a cap depends on the plaque morphology and the material characteristics of the plaque components. A parametric study was...
journal article 2011
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Groenewegen, J.P.M. (author), Van der Steen, M. (author)
journal article 2007
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Boogerd, P. (author), Verbeek, H.J. (author), Stuivinga, M. (author), Van der Steen, A.C. (author), Schoonman, J. (author)
journal article 1995
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Boogerd, P. (author), Verbeek, H.J. (author), Stuivinga, M. (author), Van der Steen, A.C. (author), Van der Put, P.J. (author), Schoonman, J. (author)
journal article 1995
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