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Xu, X. (author), Hilberath, T. (author), Hollmann, F. (author)
Heme-dependent oxygenases (i.e. P450 monooxygenases and peroxygenases) are highly selective catalysts for the selective oxyfunctionalisation or organic compounds. Both enzyme classes exhibit mechanistic similarities (i.e. using so-called compound I (CpdI) as active oxidation species) and differences in how CpdI is formed. From the differences...
review 2023
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Hanefeld, U. (author), Hollmann, F. (author), Paul, C.E. (author)
Biocatalysis has an enormous impact on chemical synthesis. The waves in which biocatalysis has developed, and in doing so changed our perception of what organic chemistry is, were reviewed 20 and 10 years ago. Here we review the consequences of these waves of development. Nowadays, hydrolases are widely used on an industrial scale for the...
review 2022
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Beltrán-Nogal, Alejandro (author), Sánchez-Moreno, Israel (author), Méndez-Sánchez, Daniel (author), Gómez de Santos, Patricia (author), Hollmann, F. (author), Alcalde, Miguel (author)
The selective insertion of oxygen into non-activated organic molecules has to date been considered of utmost importance to synthesize existing and next generation industrial chemicals or pharmaceuticals. In this respect, the minimal requirements and high activity of fungal unspecific peroxygenases (UPOs) situate them as the jewel in the crown...
review 2022
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Yun, Chul Ho (author), Kim, Jinhyun (author), Hollmann, F. (author), Park, Chan Beum (author)
Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired approaches for sustainable chemical synthesis. Oxidative enzymes (e.g., monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenation reactions under mild conditions. To...
review 2022
document
Hollmann, F. (author), Ulber, Roland (author), Holtmann, Dirk (author)
In chemical process engineering, process intensification (PI) has proven itself as a method that resulted very often in processes with an at least doubled process performance. In recent years, the PI techniques have found more and more applications in biotechnology. Exemplary continuous processes, single-use reactors, electrobiotechnology and...
review 2021
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Alagumalai, Avinash (author), Mahian, Omid (author), Hollmann, F. (author), Zhang, Wuyuan (author)
Versatile bio-derived catalysts have been under dynamic investigation as potential substitutes to conventional chemical catalysts for sustainable biodiesel production. This is because of their unique, low-cost benefits and production processes that are environmentally and economically acceptable. This critical review aspires to present a...
review 2021
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Hobisch, Markus (author), Holtmann, Dirk (author), Gomez de Santos, Patricia (author), Alcalde, Miguel (author), Hollmann, F. (author), Kara, Selin (author)
Peroxygenases are an emerging new class of enzymes allowing selective oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 monooxygenases. Herein, we focused on recent developments from organic synthesis, molecular biotechnology and reaction engineering viewpoints that are devoted to bring these enzymes...
review 2021
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Mahor, Durga (author), Cong, Zhiqi (author), Weissenborn, Martin J. (author), Hollmann, F. (author), Zhang, Wuyuan (author)
The oxidation of alkanes into valuable chemical products is a vital reaction in organic synthesis. This reaction, however, is challenging, owing to the inertness of C−H bonds. Transition metal catalysts for C−H functionalization are frequently explored. Despite chemical alternatives, nature has also evolved powerful oxidative enzymes (e. g.,...
review 2021
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Hagedoorn, P.L. (author), Hollmann, F. (author), Hanefeld, U. (author)
Oleate hydratase catalyses the addition of water to the CC double bond of oleic acid to produce (R)-10-hydroxystearic acid. The enzyme requires an FAD cofactor that functions to optimise the active site structure. A wide range of unsaturated fatty acids can be hydrated at the C10 and in some cases the C13 position. The substrate scope can be...
review 2021
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Amoroso, Rosa (author), Hollmann, F. (author), Maccallini, Cristina (author)
DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). This attitude is due to the specific hydrogen-bond interactions network between the components of the mixture. A notable characteristic of DES is the possibility to develop...
review 2021
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Lin, Richen (author), Deng, Chen (author), Zhang, Wuyuan (author), Hollmann, F. (author), Murphy, Jerry D. (author)
Bioelectrochemical technologies such as electro-fermentation and microbial CO<sub>2</sub> electrosynthesis are emerging interdisciplinary technologies that can produce renewable fuels and chemicals (such as carboxylic acids). The benefits of electrically driven bioprocesses include improved production rate, selectivity, and carbon conversion...
review 2021
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Puetz, Hendrik (author), Puchľová, Eva (author), Vranková, Kvetoslava (author), Hollmann, F. (author)
Enzymatic methods for the oxidation of alcohols are critically reviewed. Dehydrogenases and oxidases are the most prominent biocatalysts, enabling the selective oxidation of primary alcohols into aldehydes or acids. In the case of secondary alcohols, region and/or enantioselective oxidation is possible. In this contribution, we outline the...
review 2020
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Hollmann, F. (author), Opperman, Diederik J. (author), Paul, C.E. (author)
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we...
review 2020
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Musa, Musa M. (author), Hollmann, F. (author), Mutti, Francesco G. (author)
Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of...
review 2019
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Burek, B. O. (author), Bormann, S. (author), Hollmann, F. (author), Bloh, J. Z. (author), Holtmann, D. (author)
In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded as the ultimate "green" reagent because water and oxygen are the only by-products. Besides the direct application of H<sub>2</sub>O<sub>2</sub> in chemical processes more and more enzymatic syntheses based on hydrogen peroxide were developed....
review 2019
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Martínez, Angel T. (author), Ruiz-Dueñas, Francisco J. (author), Camarero, Susana (author), Serrano, Ana (author), Linde, Dolores (author), Lund, Henrik (author), Vind, Jesper (author), Tovborg, Morten (author), Herold-Majumdar, Owik M. (author), Hofrichter, Martin (author), Liers, Christiane (author), Ullrich, René (author), Scheibner, Katrin (author), Sannia, Giovanni (author), Piscitelli, Alessandra (author), Pezzella, Cinzia (author), Sener, Mehmet E. (author), Kılıç, Sibel (author), van Berkel, Willem J.H. (author), Guallar, Victor (author), Lucas, Maria Fátima (author), Zuhse, Ralf (author), Ludwig, Roland (author), Hollmann, F. (author), Fernandez Fueyo, E. (author), Record, Eric (author), Faulds, Craig B. (author), Tortajada, Marta (author), Winckelmann, Ib (author), Rasmussen, Jo Anne (author), Gelo-Pujic, Mirjana (author), Gutiérrez, Ana (author), del Río, José C. (author), Rencoret, Jorge (author), Alcalde, Miguel (author)
Fungi produce heme-containing peroxidases and peroxygenases, flavin-containing oxidases and dehydrogenases, and different copper-containing oxidoreductases involved in the biodegradation of lignin and other recalcitrant compounds. Heme peroxidases comprise the classical ligninolytic peroxidases and the new dye-decolorizing peroxidases, while...
review 2017
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Wang, Yonghua (author), Lan, Dongming (author), Durrani, Rabia (author), Hollmann, F. (author)
Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenases with simplicity of cofactor-independent enzymes. Though many interesting applications have been reported, today ‘we have only scratched the surface’ and significant efforts are necessary to solve issues...
review 2017
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