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Kalogeropoulou, Maria (author), Diaz Payno, P.J. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
The existing 3D printing methods exhibit certain fabrication-dependent limitations for printing curved constructs that are relevant for many tissues. Four-dimensional (4D) printing is an emerging technology that is expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D printing is based on 3D printing,...
review 2024
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...
review 2024
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Pitta Kruize, Carlos (author), Panahkhahi, S. (author), Putra, N.E. (author), Diaz Payno, P.J. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author)
Bone-to-soft tissue interfaces are responsible for transferring loads between tissues with significantly dissimilar material properties. The examples of connective soft tissues are ligaments, tendons, and cartilages. Such natural tissue interfaces have unique microstructural properties and characteristics which avoid the abrupt transitions...
review 2023
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Putra, N.E. (author), Zhou, J. (author), Zadpoor, A.A. (author)
The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for...
review 2023
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Li, Yageng (author), Shi, Yixuan (author), Lu, Yuchen (author), Li, Xuan (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)
With the advancement of additive manufacturing (AM), customized vascular stents can now be fabricated to fit the curvatures and sizes of a narrowed or blocked blood vessel, thereby reducing the possibility of thrombosis and restenosis. More importantly, AM enables the design and fabrication of complex and functional stent unit cells that...
review 2023
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Yarali, E. (author), Zadpoor, A.A. (author), Staufer, U. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)
Mechanical and morphological design parameters, such as stiffness or porosity, play important roles in creating orthopedic implants and bone substitutes. However, we have only a limited understanding of how the microarchitecture of porous scaffolds contributes to bone regeneration. Meta-biomaterials are increasingly used to precisely engineer...
review 2023
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Mirzaali, Mohammad J. (author), Moosabeiki, Vahid (author), Rajaai, S.M. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Additive manufacturing (AM, also known as 3D printing) is an advanced manufacturing technique that has enabled progress in the design and fabrication of customised or patient-specific (meta-)biomaterials and biomedical devices (e.g., implants, prosthetics, and orthotics) with complex internal microstructures and tuneable properties. In the past...
review 2022
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van Hengel, I.A.J. (author), Tierolf, M.W.A.M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)
Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu...
review 2021
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Li, Yageng (author), Shi, Jirong (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)
Additively manufactured (AM) micro-architected biodegradable metals offer a unique combination of properties that are ideal for bone regeneration including biocompatibility, a fully interconnected porous structure, and the possibility to fully regenerate bony defects with native tissue upon biodegradation. Currently, the mechanical properties...
review 2021
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Jahr, H. (author), Li, Y. (author), Zhou, J. (author), Zadpoor, A.A. (author), Schröder, AKi-Uwe (author)
Treating large bone defects is still a clinical challenge without perfect solution, mainly due to the unavailability of suitable bone implants. Additively manufactured (AM) absorbable porous metals provide unparalleled opportunities to realize the challenging requirements for bone-mimetic implants. Firstly, multi-scale geometries of such...
review 2021
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Salandova, M. (author), van Hengel, I.A.J. (author), Apachitei, I. (author), Zadpoor, A.A. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author)
Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper,...
review 2021
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Li, Y. (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Partially due to the unavailability of ideal bone substitutes, the treatment of large bony defects remains one of the most important challenges of orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling the requirements of an ideal bone...
review 2020
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Putra, N.E. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Zhou, J. (author), Zadpoor, A.A. (author)
The growing interest in multi-functional metallic biomaterials for bone substitutes challenges the current additive manufacturing (AM, =3D printing) technologies. It is foreseeable that advances in multi-material AM for metallic biomaterials will not only allow for complex geometrical designs, but also improve their multi-functionalities by...
review 2020
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Honig, Floris (author), Vermeulen, Steven (author), Zadpoor, A.A. (author), de Boer, Jan (author), Fratila-Apachitei, E.L. (author)
The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that...
review 2020
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Callens, S.J.P. (author), Uyttendaele, Rafael J.C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
Recent evidence clearly shows that cells respond to various physical cues in their environments, guiding many cellular processes and tissue morphogenesis, pathology, and repair. One aspect that is gaining significant traction is the role of local geometry as an extracellular cue. Elucidating how geometry affects cell and tissue behavior is,...
review 2020
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Modaresifar, K. (author), Azizian Amiri, S. (author), Ganjian, M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
We systematically reviewed the currently available evidence on how the design parameters of surface nanopatterns (e.g. height, diameter, and interspacing) relate to their bactericidal behavior. The systematic search of the literature resulted in 46 studies that satisfied the inclusion criteria of examining the bactericidal behavior of...
review 2019
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Sarkiri, Maria (author), Fox, Stephan C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and...
review 2019
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Fokker, M. C. (author), Janbaz, S. (author), Zadpoor, A.A. (author)
crumpled thin sheets exhibit extraordinary characteristics such as a high strength combined with a low volume ratio. This review focuses on the physics of crumpled thin sheets, including the crumpling mechanics, crumpling methods, and the mechanical behavior of crumpled thin sheets. Most of the physical and mechanical properties of crumpled...
review 2019
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Safai, Lauren (author), Cuellar Lopez, J.S. (author), Smit, G. (author), Zadpoor, A.A. (author)
As additive manufacturing of polymeric materials is becoming more prevalent throughout industry and research communities, it is important to ensure that 3D printed parts are able to withstand mechanical and environmental stresses that occur when in use, including the sub-critical cyclic loads that could result in fatigue crack propagation and...
review 2019
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de Jonge, Christa P. (author), Kolken, H.M.A. (author), Zadpoor, A.A. (author)
The concept of "mechanical metamaterials" has become increasingly popular, since their macro-scale characteristics can be designed to exhibit unusual combinations of mechanical properties on the micro-scale. The advances in additive manufacturing (AM, three-dimensional printing) techniques have boosted the fabrication of these mechanical...
review 2019
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