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de Man, P. (author), van Straten, B.J. (author), van den Dobbelsteen, J.J. (author), van der Eijk, A. (author), Dekker, S. (author), Horeman, T. (author), Koeleman, H. (author)
other 2020
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Waafi, Affan K. (author), Gaio, N. (author), Quiros Solano, W.F. (author), Dijkstra, Paul (author), Sarro, P.M. (author), Dekker, R. (author)
We present the first Organ-on-Chip equipped with a low-impedance Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) MicroElectrode Array (MEA). The novel device allows simultaneous mechanical stimulation with a stretchable PDMS membrane and electrical monitoring via the PEDOT:PSS MEA of multiple in vitro cell cultures. The...
journal article 2020
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Last, M.G.F. (author), Deshpande, S.R. (author), Dekker, C. (author)
Membraneless organelles formed by liquid-liquid phase separation are dynamic structures that are employed by cells to spatiotemporally regulate their interior. Indeed, complex coacervation-based phase separation is involved in a multitude of biological tasks ranging from photosynthesis to cell division to chromatin organization, and more....
journal article 2020
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Smith, Kathleen Beth (author), Wehrli, Monika (author), Japaridze, A. (author), Assenza, Salvatore (author), Dekker, C. (author), Mezzenga, Raffaele (author)
The fine interplay between the simultaneous stretching and confinement of amyloid fibrils is probed by combining a microcapillary setup with atomic force microscopy. Single-molecule statistics reveal how the stretching of fibrils changed from force to confinement dominated at different length scales. System order, however, is solely ruled by...
journal article 2020
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Japaridze, A. (author), Gogou, Christos (author), Kerssemakers, J.W.J. (author), Nguyen, Huyen My (author), Dekker, C. (author)
The replication and transfer of genomic material from a cell to its progeny are vital processes in all living systems. Here we visualize the process of chromosome replication in widened E. coli cells. Monitoring the replication of single chromosomes yields clear examples of replication bubbles that reveal that the two replisomes move...
journal article 2020
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Kaczmarczyk, A.P. (author), Meng, He (author), Ordu, O. (author), Noort, John van (author), Dekker, N.H. (author)
Torsional stress generated during DNA replication and transcription has been suggested to facilitate nucleosome unwrapping and thereby the progression of polymerases. However, the propagation of twist in condensed chromatin remains yet unresolved. Here, we measure how force and torque impact chromatin fibers with a nucleosome repeat length of...
journal article 2020
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Kim, E. (author), Kerssemakers, J.W.J. (author), Shaltiel, Indra A. (author), Haering, Christian H. (author), Dekker, C. (author)
Condensin, a key component of the structure maintenance of chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA<sup>1</sup>. It remains unclear, however, how condensin complexes work together to collectively package DNA into chromosomes. Here we use time-lapse single-molecule visualization to...
journal article 2020
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Størkersen, Kristine (author), Thorvaldsen, Trine (author), Kongsvik, Trond (author), Dekker, S.W.A. (author)
Over the past decades, government safety management regulation has been driven by deregulation, simplification and organization-level regimes of inspection. So-called functional rule-making requires organizations to implement safety management systems appropriate for their operations. The paradox that seems to have arisen is that...
journal article 2020
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Fragasso, A. (author), Schmid, S. (author), Dekker, C. (author)
Nanopores bear great potential as single-molecule tools for bioanalytical sensing and sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost. The detection principle relies on detecting small differences in the ionic current as biomolecules traverse the nanopore. A major bottleneck for the further progress of...
review 2020
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Reddy, N. (author), Farah, H. (author), Dekker, Thijs (author), Huang, Yilin (author), van Arem, B. (author)
There is a pressing need for road authorities to take a proactive role in the deployment of automated vehicles on the existing road network. This requires a comprehensive understanding of the road infrastructure requirements that would lead to safe operation of automated vehicles. In this context, a field test with Lane Departure Warning and...
poster 2020
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van der Meij, Leander (author), Demetriou, A.M. (author), Tulin, Marina (author), Méndez, Ileana (author), Dekker, Peter (author), Pronk, Tila (author)
There is evidence that testosterone and cortisol levels are related to the attraction of a romantic partner; testosterone levels relate to a wide range of sexual behaviors and cortisol is a crucial component in the response to stress. To investigate this, we conducted a speed-dating study among heterosexual singles. We measured salivary...
journal article 2019
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Nanbakhsh, K. (author), Kluba, M.M. (author), Pahl, Barbara (author), Bourgeois, Florian (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, V. (author)
Platinum is widely used as the electrode material for implantable devices. Owing to its high biostability and corrosion resistivity, platinum could also be used as the main metallization for tracks in active implants. Towards this goal, in this work we investigate the stability of parylene-coated Pt tracks using passive and active tests. The...
conference paper 2019
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Taneja, P. (author), Dekker, Milan (author), van Dorsser, Cornelis (author), Vellinga, T. (author)
In the present turbulent environment highlighted by energy transition, disruptive technology, and climate change impacts, adaptability and robustness are essential in long-term planning of infrastructures. This also applies to inland ports, which play an important role in the Dutch transport system. Inland ports have three major functions, i.e.,...
conference paper 2019
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Dekker, W.J.C. (author), Wiersma, S.J. (author), Bouwknegt, J. (author), Mooiman, C. (author), Pronk, J.T. (author)
In Saccharomyces cerevisiae, acyl-coenzyme A desaturation by Ole1 requires molecular oxygen. Tween 80, a poly-ethoxylated sorbitan-oleate ester, is therefore routinely included in anaerobic growth media as a source of unsaturated fatty acids (UFAs). During optimization of protocols for anaerobic bioreactor cultivation of this yeast, we...
journal article 2019
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Deshpande, S.R. (author), Brandenburg, Frank (author), Lau, A.W.H.R. (author), Last, M.G.F. (author), Spoelstra, W.K. (author), Reese, L. (author), Wunnava, Sreekar (author), Dogterom, A.M. (author), Dekker, C. (author)
Liquid-liquid phase separation (LLPS), especially coacervation, plays a crucial role in cell biology, as it forms numerous membraneless organelles in cells. Coacervates play an indispensable role in regulating intracellular biochemistry, and their dysfunction is associated with several diseases. Understanding of the LLPS dynamics would...
journal article 2019
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Bakhshaee Babaroud, N. (author), Kluba, M.M. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, V. (author)
Active implantable medical devices have been developed for diagnosis, monitoring and treatment of large variety of neural disorders. Since the mechanical properties of these devices need to be matched to the tissue, soft materials, such as polymers are often preferred as a substrate [1]. Parylene is a good candidate, as it is highly...
abstract 2019
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Kawasaki, S. (author), Giagka, V. (author), de Haas, M. (author), Louwerse, M. (author), Henneken, V. (author), van Heesch, C. (author), Dekker, R. (author)
Vagus nerve stimulators currently on the market can treat epilepsy and depression. Recent clinical trials show the potential for vagus nerve stimulation (VNS) to treat epilepsy, autoimmune disease, and traumatic brain injury. As we explore the benefits of VNS, it is expected that more possibilities for a new treatment will emerge in the future....
conference paper 2019
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Nelck, Anne-Marie (author), Sosef, Dirk (author), Zeeman, Dorine (author), Walvisch, Mick (author), Elsenaar, Erik Jan (author), Rodenburg, Paul (author), Lammers, Gerdwin (author), van Schaijk, Pieter (author), Quak, Hans (author), Havelaar, Rogier (author), van den Bosch, Jaap (author), Brinkhof, Rogier (author), Jongeneel, Joeri (author), van Duin, J.H.R. (author), Dekker, Johan (author), Donkersloot, Vincent (author), Spoelstra, Jop (author), Boverhof, Willem (author), Sijtsma, Micha (author), van Hofwegen, Tom (author), Nieuwkerk, Michiel (author), van Gompel, Luc (author)
1. Een Urban Consolidation Centre (UCC) maakt het mogelijk om de stad zero-emissie te beleveren en zorgt ervoor dat goederen gebundeld de stad in gaan. Met als doel het minder belasten van klimaat, gezondheid van mensen en leefbaarheid van de stad. 2. Het UCC is een multimodaal overslagpunt, geschikt voor een variëteit aan voertuigen....
book chapter 2019
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Schrijvers, Jim (author), van den Noort, Josien C. (author), van der Esch, Martin (author), Dekker, Joost (author), Harlaar, J. (author)
Background: Instability of the knee joint during gait is frequently reported by patients with knee osteoarthritis or an anterior cruciate ligament rupture. The assessment of instability in clinical practice and clinical research studies mainly relies on self-reporting. Alternatively, parameters measured with gait analysis have been explored...
review 2019
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Elbatsh, Ahmed M.O. (author), Kim, E. (author), Eeftens, Jorine M. (author), Raaijmakers, Jonne A. (author), van der Weide, Robin H. (author), García-Nieto, Alberto (author), Bravo, Sol (author), Ganji, Mahipal (author), Dekker, C. (author)
Condensin is a conserved SMC complex that uses its ATPase machinery to structure genomes, but how it does so is largely unknown. We show that condensin's ATPase has a dual role in chromosome condensation. Mutation of one ATPase site impairs condensation, while mutating the second site results in hyperactive condensin that compacts DNA faster...
journal article 2019
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