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Beekers, D.I. (author), Lattwein, Kirby R. (author), Kouijzer, Joop J.P. (author), Langeveld, Simone A.G. (author), Vegter, M. (author), Beurskens, Robert (author), Mastik, Frits (author), Verduyn Lunel, Rogier (author), van der Steen, A.F.W. (author), de Jong, N. (author)
Controlling microbubble-mediated drug delivery requires the underlying biological and physical mechanisms to be unraveled. To image both microbubble oscillation upon ultrasound insonification and the resulting cellular response, we developed an optical imaging system that can achieve the necessary nanosecond temporal and nanometer spatial...
journal article 2019
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Beekers, D.I. (author), van Rooij, Tom (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound contrast agents consist of gas-filled coated microbubbles that oscillate upon ultrasound insonification. Their characteristic oscillatory response provides contrast enhancement for imaging and has the potential to locally enhance drug delivery. Since microbubble response depends on the local acoustic pressure, an ultrasound...
journal article 2018
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Janjic, Jovana (author), Tan, M. (author), Daeichin, V. (author), Noothout, E.C. (author), Chen, C. (author), Chen, Z. (author), Chang, Z.Y. (author), Beurskens, Robert H.S.H. (author), van Soest, G. (author), van der Steen, A.F.W. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author), de Jong, N. (author)
Intravascular ultrasound is an imaging modality used to visualize atherosclerosis from within the inner lumen of human arteries. Complex lesions like chronic total occlusions require forward-looking intravascular ultrasound (FL-IVUS), instead of the conventional side-looking geometry. Volumetric imaging can be achieved with 2D array...
journal article 2018
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Skachkov, Ilya (author), Luan, Ying (author), Van Tiel, Sandra T. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bernsen, Monique R. (author), Kooiman, Klazina (author)
In vivo cell tracking of therapeutic, tumor, and endothelial cells is an emerging field and a promising technique for imaging cardiovascular disease and cancer development. Site-specific labeling of endothelial cells with the MRI contrast agent superparamagnetic iron oxide (SPIO) in the absence of toxic agents is challenging. Therefore, the...
journal article 2018
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Bera, D. (author), Raghunathan, S.B. (author), Chen, C. (author), Chen, Z. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Daeichin, V. (author), Vos, H.J. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, J.G. (author)
Until now, no matrix transducer has been realized for 3D transesophageal echocardiography (TEE) in pediatric patients. In 3D TEE with a matrix transducer, the biggest challenges are to connect a large number of elements to a standard ultrasound system, and to achieve a high volume rate (>200 Hz). To address these issues, we have recently...
journal article 2018
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Bera, D. (author), Van Den Adel, Franc (author), Radeljic-Jakic, Nikola (author), Lippe, Boris (author), Soozande, M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Kruizinga, P. (author), Daeichin, V. (author), Vos, H.J. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author)
We describe a 3-D multiline parallel beamforming scheme for real-time volumetric ultrasound imaging using a prototype matrix transesophageal echocardiography probe with diagonally diced elements and separated transmit and receive arrays. The elements in the smaller rectangular transmit array are directly wired to the ultrasound system. The...
journal article 2018
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Strachinaru, Mihai (author), Bosch, Johan G. (author), van Dalen, Bas M. (author), van Gils, Lennart (author), van der Steen, A.F.W. (author), de Jong, N. (author), Geleijnse, Marcel L. (author), Vos, H.J. (author)
The propagation velocity of shear waves relates to tissue stiffness. We prove that a regular clinical cardiac ultrasound system can determine shear wave velocity with a conventional unmodified tissue Doppler imaging (TDI) application. The investigation was performed on five tissue phantoms with different stiffness using a research platform...
journal article 2017
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Kokhuis, Tom J A (author), Naaijkens, Benno A. (author), Juffermans, Lynda J.M. (author), Kamp, Otto (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)
The use of stem cells for regenerative tissue repair is promising but hampered by the low number of cells delivered to the site of injury. To increase the delivery, we propose a technique in which stem cells are linked to functionalized microbubbles, creating echogenic complex dubbed StemBells. StemBells are highly susceptible to acoustic...
journal article 2017
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van Rooij, Tom (author), Beekers, D.I. (author), Lattwein, Kirby R. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)
One of the main challenges for ultrasound molecular imaging is acoustically distinguishing nonbound microbubbles from those bound to their molecular target. In this in vitro study, we compared two types of in-house produced targeted lipid-coated microbubbles, either consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, C16:0 (DPPC) or 1...
journal article 2017
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Vos, H.J. (author), van Dalen, Bas M. (author), Heinonen, Ilkka (author), Bosch, Johan G. (author), Sorop, Oana (author), Duncker, Dirk J. (author), van der Steen, A.F.W. (author), de Jong, N. (author)
Cardiac muscle stiffness can potentially be estimated non-invasively with shear wave elastography. Shear waves are present on the septal wall after mitral and aortic valve closure, thus providing an opportunity to assess stiffness in early systole and early diastole. We report on the shear wave recordings of 22 minipigs with high-frame-rate...
journal article 2017
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Daeichin, Verya (author), van Rooij, Tom (author), Skachkov, Ilya (author), Ergin, Bulent (author), Specht, Patricia A.C. (author), Lima, Alexandre (author), Ince, Can (author), Bosch, Johan G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)
Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (>15 MHz) are available for contrast-enhanced ultrasound (CEUS) imaging. Moreover, the composition of the limited commercially available UCAs for high-frequency CEUS (hfCEUS) is...
journal article 2017
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Luan, Ying (author), Renaud, Guillaume (author), Raymond, Jason L. (author), Segers, Tim (author), Lajoinie, Guillaume (author), Beurskens, Robert (author), Mastik, Frits (author), Kokhuis, Tom J A (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)
In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a...
journal article 2016
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