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Resch, V. (author), Seidler, C. (author), Chen, B.S. (author), Degeling, I. (author), Hanefeld, U. (author)
The use of water as a nucleophile for Michael additions is still a challenge in organic chemistry. In this report we describe the use of amino acids as catalysts for the Michael addition of water to ?,?-unsaturated ketones. All 20 proteinogenic amino acids were screened and L-lysine was identified as the best candidate. To obtain a better...
journal article 2013