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Bakhshaee Babaroud, N. (author), Kluba, M.M. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, V. (author)
Active implantable medical devices have been developed for diagnosis, monitoring and treatment of large variety of neural disorders. Since the mechanical properties of these devices need to be matched to the tissue, soft materials, such as polymers are often preferred as a substrate [1]. Parylene is a good candidate, as it is highly...
abstract 2019
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Malissovas, Anastasios (author), Serdijn, W.A. (author), Giagka, V. (author)
As the era of Bioelectronic medicines (BEms) evolves, new technological challenges are generated, including miniaturized devices that are encapsulated with flexible materials and energized by wireless power transmission (WPT) techniques. Among them, magnetostatic, also known as inductive, and ultrasound (US) are the most viable candidates for...
abstract 2019
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Wardhana, Gandhika K (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, V. (author), Vollebregt, Sten (author)
Neural interface in the form of microelectrodes are used to monitor and treat spinal cord injury and other neurological disorders by the means of recording and stimulation. Despite of the apparent result of these electrical interventions, understanding of the mechanism behind neural stimulation is still inadequate. The use of optical monitoring...
abstract 2019
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Martins da Ponte, R. (author), Huang, C. (author), Giagka, V. (author), Serdijn, W.A. (author)
Optogenetics is a neuromodulation method that holds great potential for the realization of advanced neuroprostheses due to its precise spatial-temporal control of neuronal activity [1]. The development of novel optogenetic implants (optrodes) may open new doors to investigate complex brain circuitry and chronical brain disorders, such as...
abstract 2019
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Martins da Ponte, R. (author), Giagka, V. (author), Serdijn, W.A. (author)
Incubators in cell cultures are used to grow and maintain cells under optimal temperature alongside other key variables, such as pH, humidity, atmospheric conditions etc. As enzymatic activity and protein synthesis proceed optimally at 37.5 oC, a temperature rise can cause protein denaturation, whereas a drop in temperature can slow down...
abstract 2019
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Nanbakhsh, K. (author), Serdijn, W.A. (author), Giagka, V. (author)
The main goal of bioelectronic medicine is to, one day, replace conventional chemical drugs with miniaturized implants. This way, tiny electrical pulses will be locally delivered to a small group of neurons in order to influence and modify biological functions. Developing such implants, however, has brought many new challenges both in the...
abstract 2019
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Pak, A. (author), Serdijn, W.A. (author), Giagka, V. (author)
Electronic components in the form of application-specific integrated circuits (ASICs) establishing the communication between the body and the implant, such as stimulation and recording, have, nowadays, become essential elements for current and future generations of implantable devices, as medicine is looking into substituting its traditional...
abstract 2019
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