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Telepresence for surgical assistance and training using eXtended reality during and after pandemic periods

Wisotzky, Eric L. (author), Rosenthal, Jean Claude (author), Meij, S.E.P. (author), van den Dobbelsteen, J.J. (author), Arens, Philipp (author), Hilsmann, Anna (author), Eisert, Peter (author), Uecker, Florian Cornelius (author), Schneider, Armin (author)

Existing challenges in surgical education (See one, do one, teach one) as well as the COVID-19 pandemic make it necessary to develop new ways for surgical training. Therefore, this work describes the implementation of a scalable remote solution called “TeleSTAR” using immersive, interactive and augmented reality elements which enhances...

journal article 2023

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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)

Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...

journal article 2023

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A remote and immersive setup for pandemic-safe surgical education

Rosenthal, Jean Claude (author), Schneider, Armin (author), Wisotzky, Eric L. (author), Meij, S.E.P. (author), van den Dobbelsteen, J.J. (author), Arens, Philipp (author), Uecker, Florian C. (author)

Existing challenges in surgical education (See one, do one, teach one) as well as the Covid-19 pandemic make it necessary to develop new ways for surgical training. This is also crucial for the dissemination of new technological developments. As today's live transmissions of surgeries to remote locations always come with high information loss...

journal article 2021

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Memory CD8⁺ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment

van der Gracht, Esmé T.I. (author), Beyrend, Guillaume (author), Abdelaal, T.R.M. (author), Pardieck, Iris N. (author), Wesselink, Thomas H. (author), van Haften, Floortje J. (author), van Duikeren, Suzanne (author), Koning, Frits (author), Arens, Ramon (author)

SummaryFactors that govern the complex formation of memory T cells are not completelyunderstood. A better understanding of thedevelopment of memory Tcell hetero-geneity is however required to enhance vaccination and immunotherapy ap-proaches. Here we examined the impact of pathogen- and tissue-specific cueson memory CD8+T cell heterogeneity...

journal article 2021

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Comment on ‘Is ‘re-mobilisation’ nature restoration or nature destruction? A commentary’ by I. Delgado-Fernandez, R.G.D. Davidson-Arnott & P.A. Hesp

Arens, Sebastiaan M. (author), de Vries, S. (author), Geelen, Luc HWT (author), Ruessink, Gerben (author), van der Hagen, Harrie GJM (author), Groenedijk, Dick (author)

In their recently published paper, Delgado-Fernandez et al. (2019) critically review the limitations and dangers of the relatively recent shift towards dune rejuvenation management in North-western Europe. We would like to comment on the paper from the Dutch perspective.

journal article 2020

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PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Beyrend, Guillaume (author), van der Gracht, Esmé (author), Yilmaz, Ayse (author), van Duikeren, Suzanne (author), Camps, Marcel (author), Höllt, T. (author), Vilanova Bartroli, A. (author), van Unen, Vincent (author), Koning, Frits (author), de Miranda, Noel F. C. C. (author), Arens, Ramon (author), Ossendorp, Ferry (author)

Background: The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of patients. Combination immunotherapy offers an attractive avenue to develop more effective cancer therapies by improving the efficacy and duration of the tumor-specific T-cell...

journal article 2019

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The contribution of cytomegalovirus infection to immune senescence is set by the infectious dose

Redeker, Anke (author), Remmerswaal, Ester B.M. (author), van der Gracht, Esmé T.I. (author), Welten, Suzanne P.M. (author), Höllt, T. (author), Koning, Frits (author), Cicin-Sain, Luka (author), Nikolich-Žugich, Janko (author), ten Berge, Ineke J.M. (author), van Lier, René A. W. (author), van Unen, Vincent (author), Arens, Ramon (author)

The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...

journal article 2018

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Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Beyrend, Guillaume (author), Stam, Koen (author), Höllt, T. (author), Ossendorp, Ferry (author), Arens, Ramon (author)

Multi-parametric flow and mass cytometry allows exceptional high-resolution exploration of the cellular composition of the immune system. A large panel of computational tools have been developed to analyze the high-dimensional landscape of the data generated. Analysis frameworks such as FlowSOM or Cytosplore incorporate clustering and...

journal article 2018

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Spatial Variability of Subsurface Soil Conditions Causing Roadway Settlements

Bilgin, Ö (author), Arens, K. (author), Salveter, M. (author)

Settlement of problematic soils constituting the roadway subgrade may result in pavement distress and structural failure, requiring periodic pavement patching and resurfacing. Many of these problems occur as a result of the settlement of soft cohesive and organic soils. Due to the extent of roadway projects and the limited frequency of boring...

conference paper 2015

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Dynamic Dunes 2015, daring solutions for Natura 200 challenges

Arens, Bas (author), Ruessink, Gerben (author), Ludlow, Duncan (author)

Proceedings of an international conference on rejuvenation of dynamic dunes and restoration of the dune habitats. The congress was held in the framework of EU Life-projects Dutch Dune Revival, in Rockanje, Netherlands.

report 2015

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Magma genesis in the Lesser Antilles Arc: Evidence from Sr-Nd-Pb-Hf isotopes of Saba volcanics

Arens, T. (author)

Saba is a volcanic island and is part of the Lesser Antilles island arc, which is related to the ongoing subduction of the Atlantic oceanic plate underneath the Caribbean plate. This arc has been studied extensively because of the recent volcanism. Also, there is a north to south gradient in chemical and isotopic composition of the lavas. This...

report 2015

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Measuring and modeling coastal dune development in the Netherlands

De Groot, A.V. (author), De Vries, S. (author), Keijsers, J.G.S. (author), Riksen, M.J.P.M. (author), Ye, Q. (author), Poortinga, A. (author), Arens, S.M. (author), Bochev-Van der Burgh, L.M. (author), Wijnberg, K.M. (author), Schretlen, J.L. (author), Van Thiel De Vries, J.S.M. (author)

conference paper 2012

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Ecobeach monitoring project, phase II - year study

Brière, C. (author), Cohen, A.B. (author), Boogaard, H.F.P. van den (author), Arens, S.M. (author)

report 2008

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IEA wind annex XX: HAWT aerodynamic and models from wind tunnel measurements - final report

Masson, C. (author), Johansen, J. (author), Sorensen, N.N. (author), Zahle, F. (author), Bak, C. (author), Madsen, H.A. (author), Politis, E. (author), Schepers, G. (author), Lindenburg, K. (author), Snel, H. (author), Van Rooij, R.P.J.O.M. (author), Arens, E.A. (author), Van Bussel, G.J.W. (author), Van Kuik, G.A.M. (author), Meng, F.Z. (author), Sant, T. (author), Knauer, A. (author), Moe, G. (author), Munduate, X. (author), Gonzalez, A. (author), Ferrer, E. (author), Gomez, S. (author), Barakos, G. (author), Ivanell, S. (author), Schreck, S. (author)

report 2008

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Ecobeach monitoring project, phase II - half-year study

Brière, C. (author), Cohen, A.B. (author), Boogaard, H.F.P. van den (author), Arens, S.M. (author)

report 2007

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Analysis of the experimental and computational flow characteristics with respect to the augmented lift phenomenon caused by blade rotation

Van Rooij, R.P.J.O.M. (author), Arens, E.A. (author)

journal article 2007

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Modelling 3D spatial objects in a Geo-DBMS using a 3D primitive

Arens, C. (author), Stoter, J.E. (author), Van Oosterom, P.J.M. (author)

conference paper 2003

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The Bowyer-Watson algorithm; An efficient implementation in a database environment

Arens, C. (author)

report 2002

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Monitoring van een grootschalige verstuiving van Limburg Stirumgebied Amsterdamse Waterleidingduinen: ontwikkeling 1995-1997

Arens, S.M. (author)

In 1995 is in de Amsterdamse Waterleidingduinen (AWD) een grootschalige verstuiving ontstaan in het gebied van het van Limburg Stirumkanaal. Het zuidelijk deel van dit extractiekanaal is in maart 1995 opgevuld met het oorspronkelijke zand, voor zover dat nog aanwezig was in "depots" die tijdens het uitgraven van het kanaal, circa 100 jaar...

report 1998

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De Kerf bij Schoorl: inventarisatie van geomorfologie en kalkgehalten

Arens, S.M. (author), Haring, R.M.K. (author)

De Schoorlse duinen worden gekenmerkt door een afwisseling van grote loopduincomplexen met uitgestrekte loopduinvlaktes. Het grootste deel van het landschap, met uitzondering van de zeereep, is gestabiliseerd, er zijn vrijwel geen actieve verstuivingen. De ingreep, het graven van de kerf, en afplaggen van de achterliggende Parnassiavallei, heeft...

report 1998