Searched for:
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Huisman, S.M.H. (author), Eising, Else (author), Mahfouz, A.M.E.T.A. (author), Vijfhuizen, L.S. (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author), Reinders, M.J.T. (author)
Migraine is a common brain disorder, with a heritability of 50%. Genome-wide association studies have identified several loci, but interpretation remains challenging. We integrated migraine GWAS data with spatial gene expression data of adult brains from the Allen Human Brain Atlas, to identify specific brain regions and molecular pathways...
poster 2016
document
Gehrmann, T. (author), Pelkmans, Jordi F. (author), Wösten, Han A.B. (author), Ohm, Robin (author), Sonnenberg, Anton (author), Baars, Johan J.P. (author), Reinders, M.J.T. (author), Abeel, T.E.P.M.F. (author)
poster 2016
document
Mahfouz, A.M.E.T.A. (author), Lelieveldt, B.P.F. (author), Grefhorst, Aldo (author), Mol, Isabel M. (author), Sips, Hetty C.M. (author), van den Heuvel, José K. (author), Visser, Jenny A. (author), Reinders, M.J.T. (author), Meijer, Onno C. (author), More Authors (author)
Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid...
poster 2015
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Mahfouz, A.M.E.T.A. (author), Ziats, Mark N. (author), Rennert, Owen M. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
We analyzed the spatial-temporal co-expression relationships of 455 genes previously implicated in Autism spectrum disorder (ASD) using the BrainSpan transcriptome atlas. Understanding how the heterogenous set of ASD-related genes contribute to normal brain development helps identifying cellular/molecular processes which are commonly disrupted...
poster 2013
document
van den Berg, B.A. (author), Thornton, JM (author), Reinders, M.J.T. (author), de Ridder, D. (author), Beer, TAP (author)
Our aim is to prioritize human missense mutations by their probability of being disease causing. Such a computational method could be used to obtain a reduced set of mutations with a relatively large fraction of disease related mutations, thereby aiding in the search for this type of mutation within a large mutation set.

Whereas a range...
poster 2013
document
Gehrmann, T. (author), Pelkmans, Jordi F. (author), Lugones, Luis G. (author), Wösten, Han A.B. (author), Reinders, M.J.T. (author)
poster 2013
document
van den Berg, B.A. (author), Reinders, M.J.T. (author), Pel, HJ (author), Roubos, J.A. (author), de Ridder, D. (author)
poster 2012
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Babaei, S. (author), Hulsman, M. (author), Reinders, M.J.T. (author), de Ridder, J. (author)
We introduce a multi-scale kernel diffusion framework and apply it to a large collection of murine retroviral insertional mutagenesis data. The diffusion strength plays the role of scale parameter. As a result, in addition to detecting genes with frequent mutations in their genomic vicinity (red nodes in the interaction graph) we can also find...
poster 2012
document
van den Berg, B.A. (author), Reinders, M.J.T. (author), Pel, HJ (author), Wu, L (author), Roubos, J.A. (author), de Ridder, D. (author)
Aspergillus niger is widely used for industrial enzyme production. Knowledge on high-level protein secretion could be useful to improve production rates. We used sequencebased classification methods to identify important properties
for successful high-level secretion, which will be used to redesign proteins for improved secretion.
poster 2011
document
Taskesen, E. (author), Havermans, M (author), Van Lom, K (author), Sanders, Mathijs (author), van Norden, Yvette (author), Bindels, Eric (author), Hoogenboezem, Remco (author), Reinders, M.J.T. (author), Valk, P.J.M. (author), More Authors (author)
Acute Myeloid Leukemia is a highly diverse disease containing many cytogenetic and molecular abnormalities. We analyzed the DNA methylation
(DMP) and gene expression profiles (GEP) of 344 AML patients using an unsupervised and supervised approach. We hypothesized to better
characterize the disease phenotype by combing these features as...
poster 2011
document
Hulsman, M. (author), Unadkat, HV (author), Cornelissen, Kamiel (author), de Boer, Jan (author), Reinders, M.J.T. (author)
poster 2011
document
van den Berg, B.A. (author), Reinders, M.J.T. (author), Bellomo, Domenico (author)
poster 2009
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