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Golubovic, M. (author), Ottens, M. (author), Witkamp, G.J. (author), Van der Wielen, L.A. (author)
The invention relates to a method of preparing a protein aggregate, wherein an aqueous protein solution is acidified with a pH that lies above the isoelectric point of the protein. In accordance with the invention, a first protein, which through acidificaiton is able to form a protein aggregate, is acidified in the presence of a second protein...
patent 2005
Hofland, G.W. (author), Van der Wielen, L.A. (author), Witkamp, G.J. (author)
The invention relates to a method for the preparation of protein agglomerates, by introducing CO2 in an aqueous protein-containing solution. According to the invention CO2 is gradually and while mixing supplied yielding spherical protein agglomerates, after which the pressure is reduced with a rate such that the spherical nature of the protein...
patent 2001