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document
Nghe, Philippe (author), Kogenaru, Manjunatha (author), Tans, S.J. (author)
Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenotypic parameters of cascade...
journal article 2018
document
Tans, R.L.M. (author)
master thesis 2017
document
De Martino, M. (author), Ershov, Dmitry (author), Tans, S.J. (author), Meyer, A.S. (author)
Microorganisms have developed an elaborate spectrum of mechanisms to respond and adapt to environmental stress conditions. Among these is the expression of dps, coding for the DNA-binding protein from starved cells. Dps becomes the dominant nucleoid- organizing protein in stationary-phase Escherichia coli cells and is required for robust...
journal article 2016
document
Moayed, F. (author), Mashaghi, A. (author), Tans, S.J. (author)
Many applications in biosensing, biomaterial engineering and single molecule biophysics require multiple non-covalent linkages between DNA, protein molecules, and surfaces that are specific yet strong. Here, we present a novel method to join proteins and dsDNA molecule at their ends, in an efficient, rapid and specific manner, based on the...
journal article 2013
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Tans, S.J. (author)
doctoral thesis 1998
document
Bezryadin, A. (author), Verschueren, A.R.M. (author), Tans, S.J. (author), Dekker, C. (author)
journal article 1998
document
Tans, S.J. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
document
Tans, S.J. (author), Devoret, M.H. (author), Dai, H. (author), Thess, A. (author), Smalley, R.E. (author), Georliga, L.J. (author), Dekker, C. (author)
journal article 1997
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Dekker, C. (author), Tans, S.J. (author), Geerligs, L.J. (author), Bezryadin, A. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
document
Dekker, C. (author), Tans, S.J. (author), Oberndorff, B. (author), Meyer, R. (author), Venema, L.C. (author)
journal article 1997
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Tans, S.J. (author), Miedema, R. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
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Liu, J. (author), Dai, H.J. (author), Hafner, J.H. (author), Colbert, D.T. (author), Smalley, R.E. (author), Tans, S.J. (author), Dekker, C. (author)
journal article 1997
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