Synergistic effects of cerium-containing bioactive glasses and apoptotic extracellular vesicles alleviate bisphosphonate-related osteonecrosis of jaw

Bisphosphonates (BPs) are commonly used to treat skeletal diseases. However, long-term use of BPs can lead to BP-related jaw bone necrosis (BRONJ), particularly in patients undergoing tooth extraction surgery. The treatment of BRONJ remains challenging due to the local inflammatory microenvironment. To address this issue, we developed...

Nanoprobes for PET/MR Imaging

The development of clinical imaging techniques significantly improves diagnostic accuracy and provides guidance for personalized treatment of individuals. However, every single imaging modality has its distinct drawbacks that cannot fully fulfil the diagnosis requirement. Thus, rational combination of different imaging modalities can achieve...

Rheological Properties of High-Viscosity Modified Asphalt Containing Warm-Mix Additives

High-viscosity modified asphalt (HVMA) is the most commonly applied method in drainage asphalt pavements. However, some disadvantages of hot-mix HVMA, including high energy consumption and unavoidable environmental pollution, should be improved. Therefore, warm-mix additive (WMA) was introduced. In this paper, the effects of WMA on the...

Efficient Variational Bayes Learning of Graphical Models with Smooth Structural Changes

Estimating a sequence of dynamic undirected graphical models, in which adjacent graphs share similar structures, is of paramount importance in various social, financial, biological, and engineering systems, since the evolution of such networks can be utilized for example to spot trends, detect anomalies, predict vulnerability, and evaluate...

Tailoring precipitation/properties and related mechanisms for a high-strength aluminum alloy plate via low-temperature retrogression and re-aging processes

The retrogression and re-aging (RRA) processes, aimed mainly at tailoring intergranular precipitates, could significantly improve the corrosion resistance (i.e., stress corrosion cracking resistance) without considerably decreasing the strength, which signifies that an efficient control of the size, distribution and evolution of intergranular...

Examining industrial air pollution embodied in trade: implications of a hypothetical China-UK FTA

Very few developed economies have a full free trade agreement (FTA) with China. This study employs one GTAP model and builds an extended environmental multi-region input–output model to investigate a hypothetical China-UK FTA, concerning embodied industrial emissions of SO2, PM2.5, NOX, and NH3. The economic sectors are also classified based on...

Unravelling key factors controlling vivianite formation during anaerobic digestion of waste activated sludge

As a product of phosphorous recovery from anaerobic digestion (AD) of waste activated sludge (WAS), vivianite has received increasing attention. However, key factors controlling vivianite formation have not yet been fully addressed. Thus, this study was initiated to ascertain key factors controlling vivianite formation. A simulation of...

Optimal Pairs Trading Strategies: A Stochastic Mean–Variance Approach

In this paper, we consider optimal pairs trading strategies in terms of static optimality and dynamic optimality under mean–variance criterion. The spread of the entity pairs is assumed to be mean-reverting and follows an Ornstein–Uhlenbeck process. A constrained optimal control problem is considered, and the Lagrange multiplier technique is...

Thermodynamic modelling of the reactions of self-healing agents and the chemical binding of aggressive ions in seawater

In this study, a new concept on self healing of cracks that the ingressive ions in the crack is chemically bound to improve the self-healing efficiency was proposed for cracked cementitious materials in a marine environment. Thermodynamic modeling was performed to determine the appropriate masses and ratio of Ca2+ and Al3+ provided by chemical...

Reactions of self-healing agents and the chemical binding of aggressive ions in sea water: Thermodynamics and kinetics

New self-healing agents that can chemically bind seawater ions invading cracked cementitious materials were proposed. The potential of self-healing and binding of seawater ions were investigated by thermodynamic modeling. It was found that CaO-NaAlO₂ and CaO-metakaolin agents can have Cl⁻, SO₄²⁻ and...

The dynamic behavior of gas hydrate dissociation by heating in tight sandy reservoirs: A molecular dynamics simulation study

Knowledge on the kinetics of gas hydrate dissociation in microporous sediments is very important for developing safe and efficient approaches to gas recovery from natural gas hydrate (NGH) deposits. Herein, molecular dynamics (MD) simulations are used to study the dissociation kinetics in microporous sediments. The hydrate phase occupies a...

Multityped Community Discovery in Time-Evolving Heterogeneous Information Networks Based on Tensor Decomposition

The heterogeneous information networks are omnipresent in real-world applications, which consist of multiple types of objects with various rich semantic meaningful links among them. Community discovery is an effective method to extract the hidden structures in networks. Usually, heterogeneous information networks are time-evolving, whose objects...

Investigation of self healing behaviour of asphalt mixes using beam on elastic foundation setup

Self healing of asphalt mixes is known for more than four decades. However, it is a complex phenomenon which depends on the duration of the rest period, temperature, crack size, etc. In order to quantify the self healing behaviour of asphalt mixes, a test setup was proposed in this research using an asphalt beam on an elastic foundation. Within...

Evaluating Self Healing Capability of Bituminous Mastics

The self-healing capability of bituminous materials has been known for many years. Researches were mostly focused on the self healing behaviour during load repetitions. The tests are either time consuming and/or complex. In this paper, a simple self healing test procedure is presented combining the fracture-healing-re-fracture test (FHR) with...

Self healing of road-use bituminous materials: Mechanical characterization and its modelling (abstract)