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Kokhuis, Tom J A (author), Naaijkens, Benno A. (author), Juffermans, Lynda J.M. (author), Kamp, Otto (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)
The use of stem cells for regenerative tissue repair is promising but hampered by the low number of cells delivered to the site of injury. To increase the delivery, we propose a technique in which stem cells are linked to functionalized microbubbles, creating echogenic complex dubbed StemBells. StemBells are highly susceptible to acoustic...
journal article 2017
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Luan, Ying (author), Renaud, Guillaume (author), Raymond, Jason L. (author), Segers, Tim (author), Lajoinie, Guillaume (author), Beurskens, Robert (author), Mastik, Frits (author), Kokhuis, Tom J A (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)
In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a...
journal article 2016
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Woudstra, L. (author), Krijnen, PAJ (author), Bogaards, SJP (author), Meinster, E (author), Emmens, RW (author), Kokhuis, TJA (author), Bollen, IAE (author), Baltzer, H (author), Baart, SMT (author), Parbhudayal, R (author), de Jong, N. (author), Helder, MN (author), Hinsbergh, V.W.M. (author), Musters, RJP (author), Kamp, O. (author), Niessen, H.W.M. (author), van Dijk, A. (author), Juffermans, LJ (author)
Successful stem cell therapy after acute myocardial infarction (AMI) is hindered by lack of engraftment of sufficient stem cells at the site of injury. We designed a novel technique to overcome this problem by assembling stem cell-microbubble complexes, named 'StemBells'. StemBells were assembled through binding of dual-targeted microbubbles (...
journal article 2016