Severson, Tesa M. (author), Wolf, Denise M. (author), Yau, Christina (author), Peeters, Justine (author), Wehkam, Diederik (author), Schouten, Philip C. (author), Chin, Suet-Feung (author), Majewski, Ian J. (author), Michaut, Magali (author), Bosma, Astrid (author), Pereira, Bernard (author), Bismeijer, Tycho (author), Wessels, L.F.A. (author), Caldas, Carlos (author), Bernards, Rene (author), Simon, Iris M. (author), Glas, Annuska M. (author), Linn, Sabine C. (author), van 't Veer, Laura (author) Background: Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like tumors. We hypothesized that these tumors may also be more sensitive to PARP inhibitors than standard treatments. Methods:...
journal article 2017
