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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)Isobutanol is a highly attractive renewable alternative to conventional fossil fuels, with superior fuel properties as compared to ethanol and 1-butanol. Even though the isobutanol production by fermentation has significant potential, complex downstream processing is limiting the wide-spreading of this technology. Accordingly, this original...journal article 2024
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Straathof, R. (author), Meijaard, J.P. (author), Perez, S.M. (author), Kolkman-Deurloo, Inger Karine K. (author), Nout, Remi A. (author), Heijmen, Ben J.M. (author), Wauben, L.S.G.L. (author), Dankelman, J. (author), van de Berg, N.J. (author)Background: The steep radiation dose gradients in cervical cancer brachytherapy (BT) necessitate a thorough understanding of the behavior of afterloader source cables or needles in the curved channels of (patient-tailored) applicators. Purpose: The purpose of this study is to develop and validate computer models to simulate: (1) BT source...journal article 2024
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), McGregor, Ian R. (author), Kiss, A.A. (author)Distillation is the most used separation technology at industrial-scale, but using distillation in bio-based processes (e.g. fermentation processes to produce bioethanol) is quite challenging when mild temperatures are needed to keep the microbes alive. Vacuum distillation can be used to perform evaporation at low temperatures, but setting a...journal article 2024
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)Isopropanol-butanol-ethanol (IBE) fermentation is a superior biofuel production technology as compared to acetone-butanol-ethanol (ABE) fermentation due to the better fuel properties of the obtained products. However, low product concentrations, thermodynamic constraints and the presence of microorganisms lead to complex downstream processing...journal article 2024
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)Increasing concerns over environmental pollution, climate change and energy security are driving a necessary transition from fossil carbon sources to more sustainable alternatives. Due to lower environmental impact, biochemicals are rapidly gaining significance as a potential renewable solution, particularly of interest in Europe. In this...journal article 2023
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Straathof, Adrie J.J. (author)Microbial conversions are generally inhibited by their products. This product inhibition is particularly dependent on the product's hydrophobicity and on its acid dissociation behaviour, hence on pH. Dependence on the microbial strain is relatively modest according to many published data. Since product inhibition has various mechanistic...review 2023
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)BACKGROUND: Isopropanol and acetone production by syngas fermentation is a promising alternative to conventional fossil carbon-dependent production. However, this alternative technology has not yet been scaled up to an industrial level owing to the relatively low product concentrations (about 5 wt% in total). This original research aims to...journal article 2023
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Shijaz, H. (author), Gallucci, Fausto (author), Straathof, Adrie J.J. (author), Posada Duque, J.A. (author)Syngas fermentation is a biochemical pathway to produce ethanol and has been commercialized successfully. The economic viability of this process could be further improved to become more competitive in the existing ethanol market. Improving gas utilization is the key, and can be done by recycling the unreacted syngas. This work is an early...book chapter 2023
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Lyu, D. (author), Straathof, C.A. (author), Soeiro, Thiago B. (author), Qin, Z. (author), Bauer, P. (author)A variable switching frequency modulation for the Dual Active Bridge (DAB) converter is proposed in this paper. With this variable switching frequency modulation, the DAB converter can be operated in the ZVS-beneficial operational modes without the necessity to transition to others, thus a larger ZVS range for the DAB converter can be...conference paper 2023
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Winkelhorst, O.M. (author), Cabau Peinado, O. (author), Straathof, Adrie J.J. (author), Jourdin, L. (author)Microbial electrochemical technologies (METs) employ microorganisms utilizing solid-state electrodes as either electron sink or electron source, such as in microbial electrosynthesis (MES). METs reaction rate is traditionally normalized to the electrode dimensions or to the electrolyte volume, but should also be normalized to biomass amount...journal article 2023
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)Syngas fermentation is used industrially to produce diluted bioethanol (about 1–6 wt%). This research study proposes a novel downstream process that recovers bioethanol in an energy-efficient and cost-effective manner, improves fermentation yield by recycling all fermentation broth components (microbes, acetate and water), and is designed for...journal article 2023
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Perdigão Elisiário, M. (author), Van Hecke, Wouter (author), De Wever, Heleen (author), Noorman, H.J. (author), Straathof, Adrie J.J. (author)Abstract: Syngas fermentation is a leading microbial process for the conversion of carbon monoxide, carbon dioxide, and hydrogen to valuable biochemicals. Clostridium autoethanogenum stands as a model organism for this process, showcasing its ability to convert syngas into ethanol industrially with simultaneous fixation of carbon and...journal article 2023
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)Lignocellulosic biomass potentially represents a great feedstock for biofuel production, but its’ pretreatment needs to be enhanced in order to make biorefineries competitive with fossil fuel based alternatives. One way to make biorefineries more economically viable is to recover and valorize all generated by-products during the biomass...book chapter 2023
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Jankovic, T.J. (author), Straathof, Adrie J.J. (author), Kiss, A.A. (author)This original research contributes to enhancing the viability of biorefineries through recovering valuable by-products from the liquid remaining after the biomass pretreatment by hot liquid water. A novel downstream processing method is developed for the recovery of acetic acid, formic acid, furfural and 5-hydroxymethylfurfural (HMF) by...journal article 2023
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Lyu, D. (author), Straathof, C.A. (author), Soeiro, Thiago B. (author), Qin, Z. (author), Bauer, P. (author)This paper proposes two modulation schemes for Dual Active Bridge (DAB) converters, with the aim of maximizing Zero Voltage Switching (ZVS) operation over a wide operational range. The first is a ZVS-optimized constant frequency modulation scheme, constructed based on the boundary conditions of ZVS operation. This scheme maximizes the number...journal article 2023
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Puiman, L. (author), Perdigão Elisiário, M. (author), Crasborn, Lilo M.L. (author), Wagenaar, Liselot E.C.H. (author), Straathof, Adrie J.J. (author), Haringa, C. (author)In gas fermentations (using O2, CO, H2, CH4 or CO2), gas-to-liquid mass transfer is often regarded as one of the limiting processes. However, it is widely known that components in fermentation broths (e.g., salts, biomass, proteins, antifoam, and organic products such as alcohols and acids) have tremendous impact on the volumetric mass transfer...journal article 2022
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Perdigão Elisiário, M. (author), De Wever, Heleen (author), Van Hecke, Wouter (author), Noorman, H.J. (author), Straathof, Adrie J.J. (author)Syngas fermentation to biofuels and chemicals is an emerging technology in the biobased economy. Mass transfer is usually limiting the syngas fermentation rate, due to the low aqueous solubilities of the gaseous substrates. Membrane bioreactors, as efficient gas–liquid contactors, are a promising configuration for overcoming this gas-to...review 2021
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Cabau Peinado, O. (author), Straathof, Adrie J.J. (author), Jourdin, L. (author)Up to now, computational modeling of microbial electrosynthesis (MES) has been underexplored, but is necessary to achieve breakthrough understanding of the process-limiting steps. Here, a general framework for modeling microbial kinetics in a MES reactor is presented. A thermodynamic approach is used to link microbial metabolism to the...journal article 2021
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Jimenez Gutierrez, J.M. (author), Verlinden, Rob A.J. (author), van der Meer, Peter C. (author), van der Wielen, L.A.M. (author), Straathof, Adrie J.J. (author)Liquid hot water pretreatment is considered to be a promising method for increaing biomass digestibility due to the moderate operational conditions without chemical additionA necessary step towards the scalability of this pretreatment process is performing pilot plant triaUpscaling was evaluated with a scaling factor of 500, by using 50 mL in...journal article 2021
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Fernando Foncillas, C. (author), Cabrera Rodriguez, C.I. (author), Caparrós-Salvador, Francisco (author), Varrone, Cristiano (author), Straathof, Adrie J.J. (author)The aim of this work was to recover a mixture of carboxylates ranging from 2 to 7 carbon atoms using a strong anion exchange resin, followed by desorption with CO<sub>2</sub>-expanded methanol. Medium chain carboxylates hexanoate and heptanoate adsorbed better than acetate, and the corresponding medium chain carboxylic acids desorbed easier...journal article 2021