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Bouts, Mark J.R.J. (author), Van Der Grond, Jeroen (author), Vernooij, Meike W. (author), Koini, Marisa (author), Schouten, T.M. (author), de Vos, Frank (author), Feis, Rogier A. (author), Lechner, Anita (author), Niessen, W.J. (author), More Authors (author)
Early and accurate mild cognitive impairment (MCI) detection within a heterogeneous, nonclinical population is needed to improve care for persons at risk of developing dementia. Magnetic resonance imaging (MRI)-based classification may aid early diagnosis of MCI, but has only been applied within clinical cohorts. We aimed to determine the...
journal article 2019
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Achterberg, Hakim C. (author), Sørensen, Lauge (author), Wolters, Frank J, (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Ikram, Mohammad Arfan (author), Nielsen, Mads (author), de Bruijne, Marleen (author)
Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value...
journal article 2019
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Vinke, Elisabeth J. (author), Huizinga, W. (author), Bergtholdt, Martin (author), Adams, Hieab H. (author), Steketee, Rebecca M E (author), Papma, Janne M. (author), De Jong, Frank Jan (author), Niessen, W.J. (author), Ikram, Mohammad Arfan (author), More Authors (author)
Brain imaging data are increasingly made publicly accessible, and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient's base population, nor are imaging parameters such as field...
journal article 2019
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Vinke, Elisabeth J. (author), de Groot, Marius (author), Venkatraghavan, Vikram (author), Klein, S. (author), Niessen, W.J. (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author)
With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross...
journal article 2018
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Keo, D.L. (author), Aziz, N. Ahmad (author), Dzyubachyk, Oleh (author), Van Der Grond, Jeroen (author), van Roon-Mom, Willeke M.C. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Cytosine-adenine-guanine (CAG) repeat expansions in the coding regions of nine polyglutamine (polyQ) genes (HTT, ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATN1, AR, and TBP) are the cause of several neurodegenerative diseases including Huntington’s disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy, and...
journal article 2017
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Sun, Zhuo (author), van de Giessen, M. (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
Mild Cognitive Impairment (MCI) is an intermediate stage between healthy and Alzheimer’s disease (AD). To enable early intervention it is important to identify the MCI subjects that will convert to AD in an early stage. In this paper, we provide a new method to distinguish between MCI patients that either convert to Alzheimer’s Disease (MCIc)...
journal article 2017
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), de Jong, Sebastiaan (author), Rieff, Nathalie (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
Magnetic resonance imaging (MRI) has become increasingly important in ischemic stroke experiments in mice, especially because it enables longitudinal studies. Still, quantitative analysis of MRI data remains challenging mainly because segmentation of mouse brain lesions in MRI data heavily relies on time-consuming manual tracing and...
journal article 2017
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), De Jong, Sebastiaan (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017)...
journal article 2017
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Hammelrath, Luam (author), Škokić, Siniša (author), Khmelinskii, Artem (author), Hess, Andreas (author), van der Knaap, Noortje (author), Staring, M. (author), Lelieveldt, B.P.F. (author), Wiedermann, Dirk (author), Hoehn, Mathias (author)
With the wide access to studies of selected gene expressions in transgenic animals,mice have become the dominant species as cerebral diseasemodels. Many of these studies are performed on animals of not more than eight weeks, declared as adult animals. Based on the earlier reports that full brain maturation requires at least three months in rats,...
journal article 2016
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Lee, R.A. (author), Van Zundert, A.A. (author), Breedveld, P. (author), Wondergem, J.H. (author), Peek, D. (author), Wieringa, P.A. (author)
Background and Objectives : Anesthesiologists are reluctant to consider higher levels for spinal anesthesia, largely due to direct threats to the spinal cord. The goal of this study is to investigate, with magnetic resonance imaging (MRI), the distances between the relevant structures of the spinal canal (spinal cord, thecal tissue, etc.) to...
journal article 2007
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Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)
Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....
journal article 2006
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