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van den Broek, M.J. (author)In the current state of model-based wind farm flow control, the implementation of yaw-based wake steering based on steady-state models has demonstrated potential for improving wind farm power production. However, for realistic, time-varying wind directions, the dynamics of wake propagation may impact the effectiveness of wake redirection. This...doctoral thesis 2024
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Stoop, Laurens P. (author), Van Der Wiel, Karin (author), Zappa, William (author), Haverkamp, Arno (author), Feelders, Ad J. (author), van den Broek, M.A. (author)We propose an index to quantify and analyse the impact of climatological variability on the energy system at different timescales. We define the climatological renewable energy deviation index (credi) as the cumulative anomaly of a renewable resource with respect to its climate over a specific time period of interest. For this we introduce the...journal article 2024
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Béres, Rebeka (author), Junginger, Martin (author), van den Broek, M.A. (author)To achieve the European Union's goal of climate neutrality by 2050, negative emissions may be required to compensate for emissions exceeding allocated carbon budgets. Therefore, carbon removal technologies such as bioenergy with carbon capture (BECCS) and direct air capture (DAC) may need to play a pivotal role in the power system. To design...journal article 2024
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Ehrmann, Anja K. (author), Wronska, A.K. (author), Perli, T. (author), de Hulster, A.F. (author), Luttik, M.A.H. (author), van den Broek, M.A. (author), Carqueija Cardoso, D.C. (author), Pronk, J.T. (author), Daran, J.G. (author)Chemically defined media for cultivation of Saccharomyces cerevisiae strains are commonly supplemented with a mixture of multiple Class-B vitamins, whose omission leads to strongly reduced growth rates. Fast growth without vitamin supplementation is interesting for industrial applications, as it reduces costs and complexity of medium...journal article 2024
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Boldrini, Annika (author), Koolen, Derck (author), Crijns-Graus, Wina (author), van den Broek, M.A. (author)The transition of the European iron and steel industry (ISI) towards low-carbon manufacturing is crucial for the European Union (EU)’s 2050 climate neutrality objective. One emerging solution is electrification by using hydrogen (H<sub>2</sub>) as iron ore reductant, which increases specific electricity use per tonne of steel up to 35 times...journal article 2024
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van den Broek, M.J. (author), Becker, M. (author), Sanderse, Benjamin (author), van Wingerden, J.W. (author)A novel dynamic economic model-predictive control strategy is presented that improves wind farm power production and reduces the additional demands of wake steering on yaw actuation when compared to an industry state-of-the-art reference controller. The novel controller takes a distributed approach to yaw control optimisation using a free-vortex...journal article 2024
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van den Broek, M.A. (author), Ortiz Merino, R.A. (author), Bennis, N.X. (author), Wronska, A.K. (author), Else-Hassing, J. (author), Daran-Lapujade, P.A.S. (author), Daran, J.G. (author)The biobased-economy aims to create a circular biotechnology ecosystem to transition from a fossil fuel-based to a sustainable industry based on biomass. For this, new microbial cell-factories are essential. We present the draft genome of the CEN.PK-derived Saccharomyces cerevisiae SpyCas9 expressing strain (IMX2600), that serve as chassis of...journal article 2024
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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)In this article the data availability statement was incorrectly given. “EGAS0000100682” should have been “EGAS00001006821”. The correct statement as follows. The datasets generated during and/or analysed during the current study are deposited at the European Genome-phenome Archive (EGA) under the accession numbers EGAS00001006821 and...journal article 2023
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van den Broek, M.J. (author), De Tavernier, D. (author), Hulsman, Paul (author), van der Hoek, D.C. (author), Sanderse, Benjamin (author), van Wingerden, J.W. (author)Near-wake effects of wind turbine models using the free-vortex wake have been studied extensively, but there is a lack of validation for such predictions in the mid to far wake. This paper presents a novel validation study using three free-vortex wake models of increasing complexity: an actuator disc, an actuator disc with rotation, and a...journal article 2023
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de Buisonjé, D. R. (author), Reijnders, T. (author), Cohen Rodrigues, T. R. (author), van den Broek, I. (author), Kraaijenhagen, R. A. (author), Janssen, V. R. (author), Kemps, H. M.C. (author), Evers, A.W.M. (author)Background: There is an urgent need to find new approaches that improve long-term adherence to a healthy lifestyle for people with cardiovascular disease (CVD). Deposit contracts (a financial incentive in which the participant deposits own money) are inexpensive and effective, but acceptability among CVD patients is unclear. This study...journal article 2023
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Koster, C.C. (author), Kleefeldt, Askar A. (author), van den Broek, M.A. (author), Luttik, M.A.H. (author), Daran, J.G. (author), Daran-Lapujade, P.A.S. (author)Mitochondria fulfil many essential roles and have their own genome, which is expressed as polycistronic transcripts that undergo co- or posttranscriptional processing and splicing. Due to the inherent complexity and limited technical accessibility of the mitochondrial transcriptome, fundamental questions regarding mitochondrial gene...journal article 2023
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Cachera, Paul (author), Olsson, Helén (author), Coumou, Hilde (author), Jensen, Mads L. (author), Sánchez, Benjamín J. (author), Strucko, Tomas (author), van den Broek, M.A. (author), Daran, J.G. (author), Jensen, Michael K. (author), Sonnenschein, Nikolaus (author), Lisby, Michael (author), Mortensen, Uffe H. (author)Biological functions are orchestrated by intricate networks of interacting genetic elements. Predicting the interaction landscape remains a challenge for systems biology and new research tools allowing simple and rapid mapping of sequence to function are desirable. Here, we describe CRI-SPA, a method allowing the transfer of chromosomal...journal article 2023
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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)Background: Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based breast cancer detection classifier. Methods: Platelet mRNA was sequenced from 266 women with stage I–IV breast cancer and 212 female controls from 6 hospitals. A particle swarm optimised...journal article 2023
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Bennis, N.X. (author), Kostanjsek, M. (author), van den Broek, M.A. (author), Daran, J.G. (author)Saccharomyces pastorianus is not a classical taxon, it is an interspecific hybrid resulting from the cross of Saccharomyces cerevisiae and Saccharomyces eubayanus. Exhibiting heterosis for phenotypic traits such as wort α-oligosaccharide consumption and fermentation at low temperature, it has been domesticated to become the main workhorse of...journal article 2023
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D'Angelo, Francesca (author), Fernandez Fueyo, E. (author), Garcia, Pierre Simon (author), Shomar Monges, H. (author), Cebola Rebelo Manuel, R.S. (author), Büke, F. (author), van den Broek, N.J.F. (author), de Ram, C. (author), Pabst, Martin (author)Iron-sulfur (Fe-S) clusters are ancient and ubiquitous protein cofactors and play irreplaceable roles in many metabolic and regulatory processes. Fe-S clusters are built and distributed to Fe-S enzymes by dedicated protein networks. The core components of these networks are widely conserved and highly versatile. However, Fe-S proteins and...journal article 2022
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Cohen Rodrigues, Talia R. (author), Reijnders, T. (author), de Buisonjé, D.R. (author), Breeman, Linda D. (author), van den Broek, Inge (author), Janssen, Veronica R. (author), Kraaijenhagen, Roderik A. (author), Atsma, D.E. (author), Evers, A.W.M. (author)Background: Lifestyle support is essential in preventing and treating cardiovascular diseases (CVD), and eHealth may be an easy and affordable solution to provide this support. However, CVD patients vary in their ability and interest to use eHealth. This study investigates demographic characteristics determining CVD patients' online and...journal article 2022
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Postma, E.D. (author), Else-Hassing, J. (author), Mangkusaputra, Venda (author), Geelhoed, J. (author), de la Torre, P. (author), van den Broek, M.A. (author), Mooiman, C. (author), Pabst, Martin (author), Daran, J.G. (author), Daran-Lapujade, P.A.S. (author)The construction of powerful cell factories requires intensive genetic engineering for the addition of new functionalities and the remodeling of native pathways and processes. The present study demonstrates the feasibility of extensive genome reprogramming using modular, specialized de novo-assembled neochromosomes in yeast. The in vivo...journal article 2022
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van den Broek, Roel (author), Hoogeveen, Han (author), van den Akker, Marjan (author), Huisman, B. (author)In this paper we consider the train unit shunting problem extended with service task scheduling. This problem originates from Dutch Railways, which is the main railway operator in the Netherlands. Its urgency stems from the upcoming expansion of the rolling stock fleet needed to handle the ever-increasing number of passengers. The problem...journal article 2022
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van den Broek, M.J. (author), Sanderse, Benjamin (author), van Wingerden, J.W. (author)Control-oriented models provide a basis for wind farm control to improve power production and reduce structural loading. Wake steering is considered to be one of the most promising techniques to achieve this. Wind turbine wakes under yaw misalignment are deflected downstream and have been shown to produce a curled or kidney-shaped structure....journal article 2022
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Göçmen, Tuhfe (author), Campagnolo, Filippo (author), Eguinoa, Irene (author), Imširović, Lejla (author), Qian, Guowei (author), Dighe, V.V. (author), Becker, M. (author), van den Broek, M.J. (author), van Wingerden, J.W. (author), Stock, Adam (author)Wind farm flow control (WFFC) is a topic of interest at several research institutes and industry and certification agencies worldwide. For reliable performance assessment of the technology, the efficiency and the capability of the models applied to WFFC should be carefully evaluated. To address that, the FarmConners consortium has launched a...journal article 2022