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Rashidi, A. (author), Varkevisser, F. (author), Giagka, Vasiliki (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)
Electrical stimulation is proven to be an effective way of neuromodulation in bioelectronic medicine (e.g. cochlear implants, deep brain stimulators, etc.), delivering localized treatment by the means of electrical pulses. To increase the stimulation efficiency and neural-type selectivity, there is an increasing interest to employ non...
abstract 2023
document
Velea, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
In an attempt to reduce the side effects caused by the chemically-based drugs used to treat neurological disorders, the field of bioelectronics has been focusing on the development of smart and reliable solutions that could, ideally, interact with the tissue at a resolution of individual cells.1 Conventionally, electrically-based systems have...
abstract 2022
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Kolovou Kouri, K. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
During the last few decades, electrical neural stimulators have successfully been employed as a means of treatment for a wide range of neurological disorders. By targeting the peripheral and central nervous systems, electrical neurostimulators activate/inhibit neural activity by manipulating the stimulus- induced electric field arising at the...
abstract 2022
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Panskus, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Over the past decades, neuromodulation has been proven to be an effective treatment for several neurological disorders. Moreover, it continues to be a rapidly evolving field with a wide-ranging potential for biomedical applications. However, efficient and patient-specific targeted neuromodulation remains one of the biggest challenges for...
abstract 2022
document
Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Harhangi, Biswadjiet (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Spinal Cord Injury (SCI) is characterized by a disruption of the spinal pathways connecting the brain to the rest of the body. This can result in an impairment or complete loss of sensory and/or motor functions, depending on the level and severity of the injury. The most common approach of attempting motor recovery using neuromodulation has been...
abstract 2021
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Akgün, O.C. (author), Serdijn, W.A. (author)
With the continuous developments in science and engineering, specifically in the fields of electronics and manufacturing, implantable electronic devices have become a reality during the last decades. Implantable electronic devices have hard design constraints: 1) As small size as possible to reduce tissue damage, 2) Minimum heat generation to...
abstract 2019
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Wardhana, Gandhika K (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, Vasiliki (author), Vollebregt, Sten (author)
Neural interface in the form of microelectrodes are used to monitor and treat spinal cord injury and other neurological disorders by the means of recording and stimulation. Despite of the apparent result of these electrical interventions, understanding of the mechanism behind neural stimulation is still inadequate. The use of optical monitoring...
abstract 2019
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Bakhshaee Babaroud, N. (author), Kluba, M.M. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Active implantable medical devices have been developed for diagnosis, monitoring and treatment of large variety of neural disorders. Since the mechanical properties of these devices need to be matched to the tissue, soft materials, such as polymers are often preferred as a substrate [1]. Parylene is a good candidate, as it is highly...
abstract 2019
document
Malissovas, Anastasios (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
As the era of Bioelectronic medicines (BEms) evolves, new technological challenges are generated, including miniaturized devices that are encapsulated with flexible materials and energized by wireless power transmission (WPT) techniques. Among them, magnetostatic, also known as inductive, and ultrasound (US) are the most viable candidates for...
abstract 2019
document
Martins Da Ponte, R. (author), Huang, C. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)
Optogenetics is a neuromodulation method that holds great potential for the realization of advanced neuroprostheses due to its precise spatial-temporal control of neuronal activity [1]. The development of novel optogenetic implants (optrodes) may open new doors to investigate complex brain circuitry and chronical brain disorders, such as...
abstract 2019
document
Martins Da Ponte, R. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)
Incubators in cell cultures are used to grow and maintain cells under optimal temperature alongside other key variables, such as pH, humidity, atmospheric conditions etc. As enzymatic activity and protein synthesis proceed optimally at 37.5 oC, a temperature rise can cause protein denaturation, whereas a drop in temperature can slow down...
abstract 2019
document
Nanbakhsh, K. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
The main goal of bioelectronic medicine is to, one day, replace conventional chemical drugs with miniaturized implants. This way, tiny electrical pulses will be locally delivered to a small group of neurons in order to influence and modify biological functions. Developing such implants, however, has brought many new challenges both in the...
abstract 2019
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Pak, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Electronic components in the form of application-specific integrated circuits (ASICs) establishing the communication between the body and the implant, such as stimulation and recording, have, nowadays, become essential elements for current and future generations of implantable devices, as medicine is looking into substituting its traditional...
abstract 2019
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Martins Da Ponte, R. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)
This research reports on the design and co-fabrication of a time-mode signal-processing in situ temperature sensor customized for the Cytostrech, an organ-on-a-chip (OOC) device. The circuit was fabricated using an in-house integrated circuit technology (BiCMOS7) that requires only seven lithographic steps to fabricate npn and MOS devices, and...
abstract 2019
document
Rout, S. (author), Mangia, Mauro (author), Pareschi, Fabio (author), Setti, Gianluca (author), Rovatti, Riccardo (author), Serdijn, W.A. (author)
Atrial electrograms (AEGs) acquired with a high spatio-temporal resolution are a promising approach for early detection of atrial fibrillation. Due to the high data rate, transmission of AEG signals is expensive in terms of power consumption and resources, making its adoption a challenge for low-power wireless devices. In this paper, we...
abstract 2019
document
Hosman, T.B. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Electronic implants are becoming a valuable tool to explore as well as regulate neural activity, potentially overcoming neural disabilities that are not yet curable. For effective exploration and regulation, it has become increasingly necessary to cover larger areas of neural tissue and to interact at a higher resolution by means of electrode...
abstract 2019
document
Pak, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)
Electronic components in the form of application-specific integrated circuits (ASICs) establishing the communication between the body and the implant, such as stimulation and recording, have, nowadays, become essential elements for current and future generations of implantable devices, as medicine is looking into substituting its traditional...
abstract 2019
document
Martins Da Ponte, R. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)
abstract 2017
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