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Eyisoylu, H. (author), Hazekamp, Emma D. (author), Cruts, Janneke (author), Koenderink, G.H. (author), de Maat, Moniek P.M. (author)The fibrin network is one of the main components of thrombi. Altered fibrin network properties are known to influence the development and progression of thrombotic disorders, at least partly through effects on the mechanical stability of fibrin. Most studies investigating the role of fibrin in thrombus properties prepare clots under static...journal article 2024
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Giubertoni, Giulia (author), Feng, Liru (author), Klein, Kevin (author), Giannetti, Guido (author), Rutten, Luco (author), van der Net, J.J.P. (author), Castro Linares, G. (author), Koenderink, G.H. (author), Woutersen, Sander (author)Water is known to play an important role in collagen self-assembly, but it is still largely unclear how water-collagen interactions influence the assembly process and determine the fibril network properties. Here, we use the H[Formula: see text]O/D[Formula: see text]O isotope effect on the hydrogen-bond strength in water to investigate the...journal article 2024
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Istúriz Petitjean, I. (author), Tran, Quang D. (author), Goutou, A. (author), Kabir, Z. (author), Wiche, Gerhard (author), Leduc, Cécile (author), Koenderink, G.H. (author)Cell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-free reconstitution. By contrast, the interactions between the three cytoskeletal networks are...journal article 2024
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Egelhaaf, Stefan U. (author), Mao, Xiaoming (author), Dijkstra, Marjolijn (author), Pine, David J (author), Kumar, Sanat K. (author), Aubin-Tam, M.E. (author), Koenderink, G.H. (author)Soft materials are usually defined as materials made of mesoscopic entities, often self-organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles, liquid crystals, foams. The importance of soft materials in everyday commodity products, as well as in technological applications,...journal article 2024
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van Tienderen, Gilles S. (author), van Beek, M.E.A. (author), Schurink, Ivo J. (author), Rosmark, Oskar (author), Roest, Henk P. (author), Demmers, J.A.A. (author), Muntz, I.A.A. (author), Conboy, J.P. (author), Koenderink, G.H. (author)Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly lung and lymph nodes, drastically reduces overall survival. However, mechanistic insight how CCA invades these metastatic sites is still lacking. This is partly because...journal article 2023
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- Van de Cauter, L. (author), Jawale, Y.K. (author), Tam, D.S.W. (author), Baldauf, L. (author), Koenderink, G.H. (author), Dogterom, A.M. (author), Ganzinger, Kristina A. (author) journal article 2023
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Martinez Torres, C.E. (author), Grimbergen, Jos (author), Koopman, Jaap (author), Koenderink, G.H. (author)Background: Fibrinogen is a plasma protein forming the fibrin scaffold of blood clots. Its mechanical properties therefore affect the risk of bleeding as well as thrombosis. There has been much recent interest in the biophysical mechanisms controlling fibrin mechanics; however, the role of molecular heterogeneity of the circulating fibrinogen...journal article 2023
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Driever, Ellen G. (author), Muntz, I.A.A. (author), Patel, Vishal (author), Adelmeijer, Jelle (author), Bernal, William (author), Koenderink, G.H. (author), Lisman, Ton (author)Background: Previous studies identified decreased clot permeability, without differences in fibrin fiber density in clots, from patients with cirrhosis compared with those from healthy controls (HCs). Fibrinogen hypersialylation could be the reason for this discrepancy. Objectives: The aim of this work was to study mechanical properties of...journal article 2023
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Van de Cauter, L. (author), van Buren, L. (author), Koenderink, G.H. (author), Ganzinger, Kristina A. (author)Creating an artificial cell from the bottom up is a long-standing challenge and, while significant progress has been made, the full realization of this goal remains elusive. Arguably, one of the biggest hurdles that researchers are facing now is the assembly of different modules of cell function inside a single container. Giant unilamellar...review 2023
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van Tienderen, Gilles S. (author), Conboy, J.P. (author), Muntz, I.A.A. (author), Willemse, Jorke (author), Tieleman, Jantine (author), Monfils, Kathryn (author), Schurink, Ivo J. (author), Demmers, J.A.A. (author), Koenderink, G.H. (author)Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix (ECM) dictate tumor processes including cell proliferation, migration, and invasion. Also in primary...journal article 2023
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Araújo, Nuno A.M. (author), Janssen, Liesbeth M.C. (author), Barois, Thomas (author), Boffetta, Guido (author), Cohen, Itai (author), Corbetta, Alessandro (author), Dauchot, Olivier (author), Dussutour, Audrey (author), Koenderink, G.H. (author)Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns from the interaction of smaller individual units. Examples are found across many scales in very different systems and scientific disciplines, from physics, materials science and robotics to biology, geophysics and astronomy. Recent research has...review 2023
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de Vries, J.J. (author), Laan, Daphne M. (author), Frey, F.F.F. (author), Koenderink, G.H. (author), de Maat, Moniek P.M. (author)Fibrous networks are essential structural components of biological and engineered materials. Accordingly, many approaches have been developed to quantify their structural properties, which define their material properties. However, a comprehensive overview and comparison of methods is lacking. Therefore, we systematically searched for...journal article 2023
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López Barreiro, D. (author), Folch-Fortuny, Abel (author), Muntz, I.A.A. (author), Thies, Jens C. (author), Sagt, Cees M.J. (author), Koenderink, G.H. (author)The biofabrication of structural proteins with controllable properties via amino acid sequence design is interesting for biomedicine and biotechnology, yet a complete framework that connects amino acid sequence to material properties is unavailable, despite great progress to establish design rules for synthesizing peptides and proteins with...journal article 2023
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Boot, R.C. (author), Roscani, A.R. (author), van Buren, L. (author), Maity, Samadarshi (author), Koenderink, G.H. (author), Boukany, P. (author)Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions control tissue mechanics and self-organization. However, most measurement techniques are limited to...journal article 2023
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Baldauf, L. (author), Frey, F.F.F. (author), Arribas Perez, M. (author), Idema, T. (author), Koenderink, G.H. (author)The actin cortex is a complex cytoskeletal machinery that drives and responds to changes in cell shape. It must generate or adapt to plasma membrane curvature to facilitate diverse functions such as cell division, migration, and phagocytosis. Due to the complex molecular makeup of the actin cortex, it remains unclear whether actin networks...journal article 2023
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Kuzmić, Mira (author), Castro Linares, G. (author), Leischner Fialová, Jindřiška (author), Iv, François (author), Salaün, Danièle (author), Llewellyn, Alex (author), Gomes, Maxime (author), Belhabib, Mayssa (author), Koenderink, G.H. (author)Septins, a family of GTP-binding proteins that assemble into higher order structures, interface with the membrane, actin filaments and microtubules, and are thus important regulators of cytoarchitecture. Septin 9 (SEPT9), which is frequently overexpressed in tumors and mutated in hereditary neuralgic amyotrophy (HNA), mediates the binding of...journal article 2022
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Muntz, I.A.A. (author), Fenu, M. (author), van Osch, G.J.V.M. (author), Koenderink, G.H. (author)Living tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal...review 2022
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Baldauf, L. (author), van Buren, L. (author), Fanalista, F. (author), Koenderink, G.H. (author)One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell division machinery. From a reconstitution perspective, the animal cell division apparatus is mechanically the simplest and therefore attractive to rebuild. An actin-based ring produces contractile force to constrict the membrane. By contrast, microbes and...review 2022
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Alkemade, C. (author), Wierenga, H. (author), Volkov, V. (author), López, Magdalena Preciado (author), Akhmanova, Anna (author), ten Wolde, Pieter Rein (author), Dogterom, A.M. (author), Koenderink, G.H. (author)The actin and microtubule cytoskeletons form active networks in the cell that can contract and remodel, resulting in vital cellular processes such as cell division and motility. Motor proteins play an important role in generating the forces required for these processes, but more recently the concept of passive cross-linkers being able to...journal article 2022
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Verwei, H.N. (author), Lee, Gloria (author), Leech, Gregor (author), Istúriz Petitjean, I. (author), Koenderink, G.H. (author), Robertson-Anderson, Rae M. (author), McGorty, Ryan James (author)Cells can crawl, self-heal, and tune their stiffness due to their remarkably dynamic cytoskeleton. As such, reconstituting networks of cytoskeletal biopolymers may lead to a host of active and adaptable materials. However, engineering such materials with precisely tuned properties requires measuring how the dynamics depend on the network...journal article 2022