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Koster, D.A. (author), Czerwinski, F. (author), Halby, L. (author), Crut, A. (author), Vekhoff, P. (author), Palle, K. (author), Arimondo, P.B. (author), Dekker, N.H. (author)
The rate of DNA supercoil removal by human topoisomerase IB (TopIB) is slowed down by the presence of the camptothecin class of antitumor drugs. By preventing religation, these drugs also prolong the lifetime of the covalent TopIB–DNA complex. Here, we use magnetic tweezers to measure the rate of supercoil removal by drugbound TopIB at a single...
journal article 2008
document
Crut, A. (author), Koster, D.A. (author), Huang, Z. (author), Hage, S. (author), Dekker, N.H. (author)
journal article 2008