- document
-
Kaaks, B.J. (author), Couweleers, S.D. (author), Lathouwers, D. (author), Kloosterman, J.L. (author), Rohde, M. (author)This work presents two color LIF temperature measurements for the transient freezing in a square channel under laminar flow conditions. This is the first time non-intrusive temperature measurements were performed within the thermal boundary layer during the transient growth of an ice layer in internal flow. A combination of a local outlier...journal article 2024
- document
-
Pastor Serrano, O. (author), Habraken, S.J.M. (author), Hoogeman, M.S. (author), Lathouwers, D. (author), Schaart, D.R. (author), Nomura, Yusuke (author), Xing, Lei (author), Perko, Z. (author)Objective. In radiotherapy, the internal movement of organs between treatment sessions causes errors in the final radiation dose delivery. To assess the need for adaptation, motion models can be used to simulate dominant motion patterns and assess anatomical robustness before delivery. Traditionally, such models are based on principal...journal article 2023
- document
-
Meric, Ilker (author), Alagoz, Enver (author), Hysing, Liv B. (author), Kögler, Toni (author), Lathouwers, D. (author), Lionheart, William R.B. (author), Mattingly, John (author), Obhodas, Jasmina (author), Rovituso, M. (author)Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet...journal article 2023
- document
-
A Geant4 based simulation platform of the HollandPTC R&D proton beamline for radiobiological studiesGroenendijk, C.F. (author), Rovituso, M. (author), Lathouwers, D. (author), Brown, J.M.C. (author)A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It implemented a six parameter non-symmetrical Gaussian pencil beam surrogate model to simulate the R&D...journal article 2023
- document
-
Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Romero, Alejandra Méndez (author), Lathouwers, D. (author), Wang, Yibing (author), Perko, Z. (author), Hoogeman, M.S. (author)Objective. The Dutch proton robustness evaluation protocol prescribes the dose of the clinical target volume (CTV) to the voxel-wise minimum (VWmin) dose of 28 scenarios. This results in a consistent but conservative near-minimum CTV dose (D98%,CTV). In this study, we analyzed (i) the correlation between VWmin/voxel-wise maximum (VWmax)...journal article 2023
- document
-
Pater, M. (author), Kaaks, B.J. (author), Lauritzen, Bent (author), Lathouwers, D. (author)The design of a molten salt reactor is largely based on CFD simulations. Phase change plays an important role in the safety of the reactor, but numerical modelling of phase change is particularly challenging. Therefore, the knowledge of the margin of error of CFD simulations involving phase change is very important. Relevant experimental...journal article 2023
- document
-
Mier Escurra, C. (author), Mor, A. R. (author), Vaessen, P.T.M. (author), Lathouwers, A.G.A. (author)One of the main difficulties in measuring partial discharges (PD) in gas-insulated substations (GIS) is the overlapping of pulses at the sensor's location, which distorts the pulse resolution and the charge estimation. This research presents a new method called “synergy,” which identifies and suppresses reflections using magnetic and electric...journal article 2023
- document
-
Burlacu, T. (author), Lathouwers, D. (author), Perko, Z. (author)In this paper we propose a solution to the need for a fast particle transport algorithm in Online Adaptive Proton Therapy capable of cheaply, but accurately computing the changes in patient dose metrics as a result of changes in the system parameters. We obtain the proton phase-space density through the product of the numerical solution to...journal article 2023
- document
-
Kaaks, B.J. (author), Rohde, M. (author), Kloosterman, J.L. (author), Lathouwers, D. (author)We present a discontinuous Galerkin method for melting/solidification problems based on the “linearized enthalpy approach,” which is derived from the conservative form of the energy transport equation and does not depend on the use of a so-called mushy zone. We use the symmetric interior penalty method and the Lax–Friedrichs flux to...journal article 2023
- document
-
Malimban, Justin (author), Lathouwers, D. (author), Qian, Haibin (author), Verhaegen, Frank (author), Wiedemann, Julia (author), Brandenburg, Sytze (author), Staring, M. (author)For image-guided small animal irradiations, the whole workflow of imaging, organ contouring, irradiation planning, and delivery is typically performed in a single session requiring continuous administration of anaesthetic agents. Automating contouring leads to a faster workflow, which limits exposure to anaesthesia and thereby, reducing its...journal article 2022
- document
-
Pastor Serrano, O. (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Hoogeman, M.S. (author), Schaart, D.R. (author), Perko, Z. (author)Breathing interplay effects in Intensity Modulated Proton Therapy (IMPT) arise from the interaction between target motion and the scanning beam. Assessing the detrimental effect of interplay and the clinical robustness of several mitigation techniques requires statistical evaluation procedures that take into account the variability of...journal article 2021
- document
-
Hennink, A. (author), Tiberga, M. (author), Lathouwers, D. (author)Over the past two decades, there has been much development in discontinuous Galerkin methods for incompressible flows and for compressible flows with a positive Mach number, but almost no attention has been paid to variable-density flows at low speeds. This paper presents a pressure-based discontinuous Galerkin method for flow in the low-Mach...journal article 2021
- document
-
Alsayyari, F.S. (author), Perko, Z. (author), Tiberga, M. (author), Kloosterman, J.L. (author), Lathouwers, D. (author)We present an approach to build a reduced-order model for nonlinear, time-dependent, parametrized partial differential equations in a nonintrusive manner. The approach is based on combining proper orthogonal decomposition (POD) with a Smolyak hierarchical interpolation model for the POD coefficients. The sampling of the high-fidelity model to...journal article 2021
- document
-
Alsayyari, F.S. (author), Tiberga, M. (author), Perko, Z. (author), Kloosterman, J.L. (author), Lathouwers, D. (author)In this paper, we present a reduced-order modeling approach to study the Molten Salt Fast Reactor (MSFR). Our approach is nonintrusive and based on the proper orthogonal decomposition method. We include adaptivity in selecting the sampling points both in time and parameter space. Steady-state and transient analysis were both performed using...journal article 2021
- document
-
Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Méndez Romero, Alejandra (author), Perko, Z. (author), Hoogeman, M.S. (author)Background and purpose: Scenario-based robust optimization and evaluation are commonly used in proton therapy (PT) with pencil beam scanning (PBS) to ensure adequate dose to the clinical target volume (CTV). However, a statistically accurate assessment of the clinical application of this approach is lacking. In this study, we assess target...journal article 2021
- document
-
Pastor Serrano, O. (author), Lathouwers, D. (author), Perko, Z. (author)Background and objective: One of the main problems with biomedical signals is the limited amount of patient-specific data and the significant amount of time needed to record the sufficient number of samples needed for diagnostic and treatment purposes. In this study, we present a framework to simultaneously generate and classify biomedical...journal article 2021
- document
-
Santanoceto, M. (author), Tiberga, M. (author), Perko, Z. (author), Dulla, Sandra (author), Lathouwers, D. (author)In this work, we present the results of a preliminary uncertainty quantification and sensitivity analysis study of the Molten Salt Fast Reactor (MSFR) behavior at steady-state performed by applying a non-intrusive Polynomial Chaos Expansion (PCE) approach. An in-house high-fidelity multi-physics simulation tool is used as reactor reference...journal article 2021
- document
-
Santanoceto, M. (author), Tiberga, M. (author), Perko, Z. (author), Dulla, Sandra (author), Lathouwers, D. (author)Uncertainty Quantification (UQ) of numerical simulations is highly relevant in the study and design of complex systems. Among the various approaches available, Polynomial Chaos Expansion (PCE) analysis has recently attracted great interest. It belongs to non-intrusive spectral projection methods and consists of constructing system responses...conference paper 2020
- document
-
Tiberga, M. (author), de Oliveira, Rodrigo Gonzalez Gonzaga (author), Cervi, Eric (author), Blanco, Juan Antonio (author), Lorenzi, Stefano (author), Aufiero, Manuele (author), Lathouwers, D. (author), Rubiolo, Pablo (author)Verification and validation of multi-physics codes dedicated to fast-spectrum molten salt reactors (MSR) is a very challenging task. Existing benchmarks are meant for single-physics codes, while experimental data for validation are absent. This is concerning, given the importance numerical simulations have in the development of fast MSR...journal article 2020
- document
-
Tiberga, M. (author), Lathouwers, D. (author), Kloosterman, J.L. (author)Performing accurate numerical simulations of molten salt reactors is challenging, especially in case of fast-spectrum designs, due to the unique physics phenomena characterizing these systems. The limitations of codes traditionally used in the nuclear community often require the development of novel high-fidelity multi-physics tools to...journal article 2020