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Tiberga, M. (author), Shafer, Devaja (author), Lathouwers, D. (author), Kloosterman, J.L. (author)This paper focuses on the freeze-plug, a key safety component of the Molten Salt Fast Reactor, one of the six Generation IV nuclear reactors that must excel in safety, reliability, and sustainability. The freeze-plug is a valve made of frozen fuel salt, designed to melt when an event requiring the core drainage occurs. It must melt passively,...conference paper 2018
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Santanoceto, M. (author), Tiberga, M. (author), Perko, Z. (author), Dulla, Sandra (author), Lathouwers, D. (author)Uncertainty Quantification (UQ) of numerical simulations is highly relevant in the study and design of complex systems. Among the various approaches available, Polynomial Chaos Expansion (PCE) analysis has recently attracted great interest. It belongs to non-intrusive spectral projection methods and consists of constructing system responses...conference paper 2020
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Gamarino, M. (author), Tomatis, D. (author), Dall'Osso, A. (author), Lathouwers, D. (author), Kloosterman, J.L. (author), van der Hagen, T.H.J.J. (author)Few-group cross sections used in nodal calculations derive from standard energy collapsing and spatial homogenization performed during preliminary lattice transport calculations, that implicitly assume an infinite array of identical fuel-assemblies. The infinite-medium neutron flux used for cross section weighting does not account for...conference paper 2016
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Tiberga, M. (author), Lathouwers, D. (author), Kloosterman, J.L. (author)Numerical simulations of fast MSRs constitute a challenging task. In fact, classical codes employed in reactor physics cannot be used, and new dedicated multi-physics tools must be developed, to capture the unique features of these systems: the strong coupling between neutronics and thermal-hydraulics due to the use of a liquid fuel, the...conference paper 2019
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- Lathouwers, D. (author) doctoral thesis 1999
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Pastor Serrano, O. (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Hoogeman, M.S. (author), Schaart, D.R. (author), Perko, Z. (author)Breathing interplay effects in Intensity Modulated Proton Therapy (IMPT) arise from the interaction between target motion and the scanning beam. Assessing the detrimental effect of interplay and the clinical robustness of several mitigation techniques requires statistical evaluation procedures that take into account the variability of...journal article 2021
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- Wols, F.J. (author), Kloosterman, J.L. (author), Lathouwers, D. (author), van der Hagen, T.H.J.J. (author) journal article 2015
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- van der Voort, S (author), van de Water, S. (author), Perko, Z. (author), Heijmen, B (author), Lathouwers, D. (author), Hoogeman, Mischa (author) journal article 2016
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- Hoogeman, M. (author), Arts, T (author), van de Water, S (author), van der Voort, S (author), Perko, Z. (author), Lathouwers, D. (author), Breedveld, S (author), Heijmen, B (author) journal article 2016
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Hennink, A. (author), Lathouwers, D. (author)We present a new discretization of the mono-energetic Fokker–Planck equation. We build on previous work (Kópházi and Lathouwers, 2015) where we devised an angular discretization for the Boltzmann equation, allowing for both heterogeneous and anisotropic angular refinement. The angular discretization is based on a discontinuous finite element...journal article 2018
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Hennink, A. (author), Tiberga, M. (author), Lathouwers, D. (author)Over the past two decades, there has been much development in discontinuous Galerkin methods for incompressible flows and for compressible flows with a positive Mach number, but almost no attention has been paid to variable-density flows at low speeds. This paper presents a pressure-based discontinuous Galerkin method for flow in the low-Mach...journal article 2021
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Alsayyari, F.S. (author), Perko, Z. (author), Tiberga, M. (author), Kloosterman, J.L. (author), Lathouwers, D. (author)We present an approach to build a reduced-order model for nonlinear, time-dependent, parametrized partial differential equations in a nonintrusive manner. The approach is based on combining proper orthogonal decomposition (POD) with a Smolyak hierarchical interpolation model for the POD coefficients. The sampling of the high-fidelity model to...journal article 2021
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Malimban, Justin (author), Lathouwers, D. (author), Qian, Haibin (author), Verhaegen, Frank (author), Wiedemann, Julia (author), Brandenburg, Sytze (author), Staring, M. (author)For image-guided small animal irradiations, the whole workflow of imaging, organ contouring, irradiation planning, and delivery is typically performed in a single session requiring continuous administration of anaesthetic agents. Automating contouring leads to a faster workflow, which limits exposure to anaesthesia and thereby, reducing its...journal article 2022
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Alsayyari, F.S. (author), Tiberga, M. (author), Perko, Z. (author), Kloosterman, J.L. (author), Lathouwers, D. (author)In this paper, we present a reduced-order modeling approach to study the Molten Salt Fast Reactor (MSFR). Our approach is nonintrusive and based on the proper orthogonal decomposition method. We include adaptivity in selecting the sampling points both in time and parameter space. Steady-state and transient analysis were both performed using...journal article 2021
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Méndez Romero, Alejandra (author), Perko, Z. (author), Hoogeman, M.S. (author)Background and purpose: Scenario-based robust optimization and evaluation are commonly used in proton therapy (PT) with pencil beam scanning (PBS) to ensure adequate dose to the clinical target volume (CTV). However, a statistically accurate assessment of the clinical application of this approach is lacking. In this study, we assess target...journal article 2021
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Pastor Serrano, O. (author), Lathouwers, D. (author), Perko, Z. (author)Background and objective: One of the main problems with biomedical signals is the limited amount of patient-specific data and the significant amount of time needed to record the sufficient number of samples needed for diagnostic and treatment purposes. In this study, we present a framework to simultaneously generate and classify biomedical...journal article 2021
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Pastor Serrano, O. (author), Habraken, S.J.M. (author), Hoogeman, M.S. (author), Lathouwers, D. (author), Schaart, D.R. (author), Nomura, Yusuke (author), Xing, Lei (author), Perko, Z. (author)Objective. In radiotherapy, the internal movement of organs between treatment sessions causes errors in the final radiation dose delivery. To assess the need for adaptation, motion models can be used to simulate dominant motion patterns and assess anatomical robustness before delivery. Traditionally, such models are based on principal...journal article 2023
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Meric, Ilker (author), Alagoz, Enver (author), Hysing, Liv B. (author), Kögler, Toni (author), Lathouwers, D. (author), Lionheart, William R.B. (author), Mattingly, John (author), Obhodas, Jasmina (author), Rovituso, M. (author)Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet...journal article 2023
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Santanoceto, M. (author), Tiberga, M. (author), Perko, Z. (author), Dulla, Sandra (author), Lathouwers, D. (author)In this work, we present the results of a preliminary uncertainty quantification and sensitivity analysis study of the Molten Salt Fast Reactor (MSFR) behavior at steady-state performed by applying a non-intrusive Polynomial Chaos Expansion (PCE) approach. An in-house high-fidelity multi-physics simulation tool is used as reactor reference...journal article 2021
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A Geant4 based simulation platform of the HollandPTC R&D proton beamline for radiobiological studiesGroenendijk, C.F. (author), Rovituso, M. (author), Lathouwers, D. (author), Brown, J.M.C. (author)A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It implemented a six parameter non-symmetrical Gaussian pencil beam surrogate model to simulate the R&D...journal article 2023