Attention as Practice: Buddhist Ethics Responses to Persuasive Technologies

The “attention economy” refers to the tech industry’s business model that treats human attention as a commodifiable resource. The libertarian critique of this model, dominant within tech and philosophical communities, claims that the persuasive technologies of the attention economy infringe on the individual user’s autonomy and therefore the...

Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex

Analyzing the Impact of Evolving Combustion Conditions on the Composition of Wildfire Emissions Using Satellite Data

Wildfires have become larger and more frequent because of climate change, increasing their impact on air pollution. Air quality forecasts and climate models do not currently account for changes in the composition of wildfire emissions during the commonly observed progression from more flaming to smoldering combustion. Laboratory measurements...

Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration

Introduction: Age related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subretinal drusenoid deposits (SDD; also called reticular pseudodrusen), disrupt cone and rod photoreceptor functions and strongly...

Estimation of drone intention using trajectory frequency defined in radar's measurement phase planes

This paper presents a radar-based algorithm for autonomous estimation of drone intention. The algorithm is based on radar's kinematic measurements, providing fast and robust intention estimation for multiple targets. The core idea of the proposed algorithm is to build intention-specific features for each intention in advance and use them in...

Lazy Lagrangians for Optimistic Learning With Budget Constraints

We consider the general problem of online convex optimization with time-varying budget constraints in the presence of predictions for the next cost and constraint functions, that arises in a plethora of network resource management problems. A novel saddle-point algorithm is designed by combining a Follow-The-Regularized-Leader iteration with...

Expanding the genome editing toolbox of Saccharomyces cerevisiae with the endonuclease ErCas12a

ErCas12a is a class 2 type V CRISPR-Cas nuclease isolated from Eubacterium rectale with attractive fundamental characteristics, such as RNA self-processing capability, and lacks reach-through royalties typical for Cas nucleases. This study aims to develop a ErCas12a-mediated genome editing tool applicable in the model yeast Saccharomyces...

Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence

Here, we describe the preservation and preparation of human kidney tissue for interrogation by histopathology, imaging mass spectrometry, and multiplexed immunofluorescence. Custom image registration and integration techniques are used to create cellular and molecular atlases of this organ system. Through careful optimization, we ensure high...

Hydropower development in the Republic of Georgia and implications for freshwater biodiversity conservation

The Caucasus region is a meeting point for culture and nature, lying at the nexus of Europe, the Middle East, Central Asia, and Africa, and identified as one of 36 global biodiversity hotspots. The Republic of Georgia, the center of the Caucasus biodiversity hotspot, encompasses a geographically diverse landscape inhabited by a remarkable,...

MFEM: A modular finite element methods library

MFEM is an open-source, lightweight, flexible and scalable C++ library for modular finite element methods that features arbitrary high-order finite element meshes and spaces, support for a wide variety of discretization approaches and emphasis on usability, portability, and high-performance computing efficiency. MFEM's goal is to provide...

Partitioning the Uncertainty of Ensemble Projections of Global Glacier Mass Change

Glacier mass loss is recognized as a major contributor to current sea level rise. However, large uncertainties remain in projections of glacier mass loss on global and regional scales. We present an ensemble of 288 glacier mass and area change projections for the 21st century based on 11 glacier models using up to 10 general circulation...

Long-term impacts of rising sea temperature and sea level on shallow water coral communities over a similar to 40 year period

Effects of combined rising sea temperature and increasing sea level on coral reefs, both factors associated with global warming, have rarely been addressed. In this ~40 y study of shallow reefs in the eastern Indian Ocean, we show that a rising relative sea level, currently estimated at ~11 mm y−1, has not only promoted coral cover but also has...

Integrating global satellite-derived data products as a pre-analysis for hydrological modelling studies: a case study for the Red River Basin

With changes in weather patterns and intensifying anthropogenic water use, there is an increasing need for spatio-temporal information on water fluxes and stocks in river basins. The assortment of satellite-derived open-access information sources on rainfall (P) and land use/land cover (LULC) is currently being expanded with the application of...

Lactic Acid Fermentation, Urea and Lime Addition: Promising Faecal Sludge Sanitizing Methods for Emergency Sanitation

In this research, three faecal sludge sanitizing methods—lactic acid fermentation, urea treatment and lime treatment—were studied for application in emergency situations. These methods were investigated by undertaking small scale field trials with pit latrine sludge in Blantyre, Malawi. Hydrated lime was able to reduce the E. coli count in the...

Global ionospheric and thermospheric response to the 5 April 2010 geomagnetic storm: An integrated data-model investigation

We present a case study of the 5 April 2010 geomagnetic storm using observations and numerical simulations. The event was driven by a fast-moving coronal mass ejection and despite being a moderate storm with a minimum Dst near ?50 nT, the event exhibited elevated thermospheric density and surges of traveling atmospheric disturbances (TADs) more...

Groundwater flow through anisotropic fault zones in multiaquifer systems

Vertical faults through the shallow crust are commonly believed to act as either barriers to horizontal groundwater flow normal to the fault, conduits to horizontal flow tangential to the fault, or a combination of both. In addition, enhanced vertical permeability has been identified as a common feature. We investigate the effects of vertical...