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Multibody dynamic modeling of the behavior of flexible instruments used in cervical cancer brachytherapy

Straathof, R. (author), Meijaard, J.P. (author), Perez, S.M. (author), Kolkman-Deurloo, Inger Karine K. (author), Nout, Remi A. (author), Heijmen, Ben J.M. (author), Wauben, L.S.G.L. (author), Dankelman, J. (author), van de Berg, N.J. (author)

Background: The steep radiation dose gradients in cervical cancer brachytherapy (BT) necessitate a thorough understanding of the behavior of afterloader source cables or needles in the curved channels of (patient-tailored) applicators. Purpose: The purpose of this study is to develop and validate computer models to simulate: (1) BT source...

journal article 2024

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Plasma Device Functions and Tissue Effects in the Female Pelvis: A Systematic Review

van de Berg, N.J. (author), Nieuwenhuyzen-de Boer, Gatske M. (author), Gao, Xu Shan (author), Rijstenberg, Lucia (author), Van Beekhuizen, Heleen J. (author)

Medical use of (non-)thermal plasmas is an emerging field in gynaecology. However, data on plasma energy dispersion remain limited. This systematic review presents an overview of plasma devices, fields of effective application, and impact of use factors and device settings on tissues in the female pelvis, including the uterus, ovaries, cervix,...

review 2023

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MR-guided HDR prostate brachytherapy with teleoperated steerable needles

de Vries, M. (author), Wijntjes, M. (author), Sikorski, J. (author), Moreira, P. (author), van de Berg, N.J. (author), van den Dobbelsteen, J.J. (author), Misra, S. (author)

Conformity of tumour volumes and dose plans in prostate brachytherapy (BT) can be constrained by unwanted needle deflections, needle access restrictions and visualisation limitations. This work validates the feasibility of teleoperated robotic control of an active steerable needle using magnetic resonance (MR) for guidance. With this system,...

journal article 2023

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Patient-Reported Mobility, Physical Activity, and Bicycle Use after Vulvar Carcinoma Surgery

van de Berg, N.J. (author), van Beurden, F.P. (author), Wendel-Vos, G. C. Wanda (author), Duijvestijn, Marjolein (author), van Beekhuizen, Heleen J. (author), Maliepaard, Marianne (author), van Doorn, Helena C. (author)

Patients treated for vulvar carcinoma may experience losses in mobility and physical activity. In this study, we assess the prevalence and severity of mobility problems using patient-reported outcomes of three questionnaires: EQ-5D-5L to estimate QoL and perceived health; SQUASH to estimate habitual physical activity; and a problem-specific...

journal article 2023

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Hyperspectral Imaging for Tissue Classification after Advanced Stage Ovarian Cancer Surgery: A Pilot Study

Perez, S.M. (author), van de Berg, N.J. (author), Manni, Francesca (author), Lai, Marco (author), Rijstenberg, Lucia (author), Hendriks, B.H.W. (author), Dankelman, J. (author), Ewing-Graham, Patricia C. (author), Nieuwenhuyzen, G.M. (author), Van Beekhuizen, Heleen J. (author)

The most important prognostic factor for the survival of advanced-stage epithelial ovarian cancer (EOC) is the completeness of cytoreductive surgery (CRS). Therefore, an intraoperative technique to detect microscopic tumors would be of great value. The aim of this pilot study is to assess the feasibility of near-infrared hyperspectral imaging ...

journal article 2022

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The effects of neutral argon plasma versus electrocoagulation on tissue in advanced-stage ovarian cancer: a case series

Nieuwenhuyzen-de Boer, Gatske M. (author), van de Berg, N.J. (author), Gao, Xu Shan (author), Ewing-Graham, Patricia C. (author), van Beekhuizen, Heleen J. (author)

Background: The aim of surgery for advanced-stage ovarian cancer is a complete cytoreduction, because this is the most important independent prognostic factor for prolonged survival. Yet this can be difficult to achieve when there are micrometastases on the intestinal mesentery or intestines. The PlasmaJet device is an instrument to remove...

journal article 2022

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An anthropomorphic deformable phantom of the vaginal wall and cavity

Somerwil, P.C. (author), Nout, Remi A. (author), Mens, Jan Willem M. (author), Kolkman-Deurloo, Inger Karine K. (author), Van Beekhuizen, Heleen J. (author), Dankelman, J. (author), van de Berg, N.J. (author)

Brachytherapy is a common treatment in cervical, uterine and vaginal cancer management. The technique is characterised by rapid developments in the fields of medical imaging, dosimetry planning and personalised medical device design. To reduce unnecessary burden on patients, assessments and training of these technologies should preferable be...

journal article 2021

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Block-matching-based registration to evaluate ultrasound visibility of percutaneous needles in liver-mimicking phantoms

Sánchez-Margallo, Juan A. (author), Tas, L. (author), Moelker, Adriaan (author), van den Dobbelsteen, J.J. (author), Sánchez-Margallo, Francisco M. (author), Langø, Thomas (author), van Walsum, T. (author), van de Berg, N.J. (author)

Purpose: To present a novel methodical approach to compare visibility of percutaneous needles in ultrasound images. Methods: A motor-driven rotation platform was used to gradually change the needle angle while capturing image data. Data analysis was automated using block-matching-based registration, with a tracking and refinement step. Every...

journal article 2021

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Steerable needles for radio-frequency ablation in cirrhotic livers

van de Berg, N.J. (author), Meeuwsen, F.C. (author), Doukas, Michail (author), Kronreif, Gernot (author), Moelker, Adriaan (author), van den Dobbelsteen, J.J. (author)

Accurate needle placement in deep-seated liver tumours can be difficult. In this work, we disclose two new manually controlled steerable needles for 17G radio-frequency ablation probe placement. The needles contain stylets with embedded compliant joints for active tip articulations, and concentric tubes for (curved-path) guidance. Needle...

journal article 2021

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Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain

Keo, D.L. (author), Dzyubachyk, Oleh (author), van der Grond, Jeroen (author), Hafkemeijer, Anne (author), van de Berg, Wilma D.J. (author), van Hilten, Jacobus J. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)

Structural covariance networks are able to identify functionally organized brain regions by gray matter volume covariance across a population. We examined the transcriptomic signature of such anatomical networks in the healthy brain using postmortem microarray data from the Allen Human Brain Atlas. A previous study revealed that a posterior...

journal article 2021

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Ultrasound-Guided Percutaneous Liver Biopsy: A Review on Obtaining Adequate Specimens

de Lange, Danny (author), van den Dobbelsteen, J.J. (author), Moelker, Adriaan (author), van de Berg, N.J. (author)

This literature review was conducted to evaluate liver biopsy adequacy, including total core length (TCL), number of portal tracts (PT), fragmentation, and complication rates, as a function of needle type and gauge. A systematic electronic search was performed in the Web of Science and Google Scholar databases, according to the PRISMA...

journal article 2020

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Low elevation of Svalbard glaciers drives high mass loss variability

Noël, Brice (author), Jakobs, C. L. (author), van Pelt, W. J.J. (author), Lhermitte, S.L.M. (author), Wouters, B. (author), Kohler, J. (author), Hagen, J. O. (author), Luks, B. (author), Reijmer, C. H. (author), van de Berg, W. J. (author), van den Broeke, M. R. (author)

Compared to other Arctic ice masses, Svalbard glaciers are low-elevated with flat interior accumulation areas, resulting in a marked peak in their current hypsometry (area-elevation distribution) at ~450 m above sea level. Since summer melt consistently exceeds winter snowfall, these low-lying glaciers can only survive by refreezing a...

journal article 2020

document

Lethal smothering with a pillow: How 181 music festival visitors tried to kill a dummy

Prinsen, D. (author), van Dijke, A.P. (author), Horeman, T. (author), van de Berg, N.J. (author), Loeve, A.J. (author)

Purpose: Smothering to death is most often done with a soft cover, such as a pillow. This is one of the hardest to diagnose causes of death. Knowing more about how people perform such an act and whether there is any correlation between perpetrator characteristics and smothering approaches may help in solving criminal cases involving...

journal article 2020

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MRI-driven design of customised 3D printed gynaecological brachytherapy applicators with curved needle channels

Laan, Rianne (author), Nout, Remi A. (author), Dankelman, J. (author), van de Berg, N.J. (author)

Background:<br/> Brachytherapy involves placement of radioactive sources inside or near the tumour. For gynaecological cancer, recent developments, including 3D imaging and image-guided adaptive brachytherapy, have improved treatment quality and outcomes. However, for large or complex tumours, target coverage and local control with commercially...

journal article 2019

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A methodical quantification of needle visibility and echogenicity in ultrasound images

van de Berg, N.J. (author), Sánchez-Margallo, Juan A. (author), van Dijke, A.P. (author), Langø, Thomas (author), van den Dobbelsteen, J.J. (author)

During ultrasound-guided percutaneous interventions, needle localization can be a challenge. To increase needle visibility, enhancements of both the imaging methods and the needle surface properties have been investigated. However, a methodical approach to compare potential solutions is currently unavailable. The work described here involves...

journal article 2019

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Rapid ablation zone expansion amplifies north Greenland mass loss

Noël, Brice (author), van de Berg, Willem Jan (author), Lhermitte, S.L.M. (author), van den Broeke, Michiel R. (author)

Since the early 1990s, the Greenland ice sheet (GrIS) has been losing mass at an accelerating rate, primarily due to enhanced meltwater runoff following atmospheric warming. Here, we show that a pronounced latitudinal contrast exists in the GrIS response to recent warming. The ablation area in north Greenland expanded by 46%, almost twice as...

journal article 2019

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Modelling the climate and surface mass balance of polar ice sheets using RACMO2 - Part 1: Greenland (1958-2016)

Noël, Brice (author), van de Berg, Willem Jan (author), Van Wessem, J. Melchior (author), Van Meijgaard, Erik (author), Van As, DIrk (author), Lenaerts, Jan T M (author), Lhermitte, S.L.M. (author), Munneke, Peter Kuipers (author), Smeets, C. J.P.Paul (author), Van Ulft, Lambertus H. (author), van de Wal, Roderik S W (author), van den Broeke, Michiel R. (author)

We evaluate modelled Greenland ice sheet (GrIS) near-surface climate, surface energy balance (SEB) and surface mass balance (SMB) from the updated regional climate model RACMO2 (1958-2016). The new model version, referred to as RACMO2.3p2, incorporates updated glacier outlines, topography and ice albedo fields. Parameters in the cloud scheme...

journal article 2018

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Compliant joint echogenicity in ultrasound images: towards highly visible steerable needles

van de Berg, N.J. (author), Sánchez-Margallo, Juan A. (author), Langø, Thomas (author), van den Dobbelsteen, J.J. (author)

Radio frequency ablation is commonly used in the treatment of hepatocellular carcinoma. Clinicians rely on imaging techniques, such as medical ultrasound, to confirm an accurate needle placement. This accuracy may improve by means of active needle steering techniques, which are currently in development. Needle steering will likely increase the...

conference paper 2018

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Needle placement errors: do we need steerable needles in interventional radiology?

de Jong, T.L. (author), van de Berg, N.J. (author), Tas, L. (author), Moelker, Adriaan (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author)

Purpose: Accurate and precise needle placement is of utmost importance in interventional radiology. However, targeting can be challenging due to, eg, tissue motion and deformation. Steerable needles are a possible solution to overcome these challenges. The present work studied the clinical need for steerable needles. We aimed to answer three...

journal article 2018

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Endpoint accuracy in manual control of a steerable needle

van de Berg, N.J. (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author)

Purpose<br/>To study the ability of a human operator to manually correct for errors in the needle insertion path without partial withdrawal of the needle by means of an active, tip-articulated steerable needle.<br/><br/>Materials and Methods<br/>The needle is composed of a 1.32-mm outer-diameter cannula, with a flexure joint near the tip, and a...

journal article 2017