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Keukeleire, P. (author), Makrodimitris, S. (author), Reinders, M.J.T. (author)
Cell-free DNA (cfDNA) are DNA fragments originating from dying cells that are detectable in bodily fluids, such as the plasma. Accelerated cell death, for example caused by disease, induces an elevated concentration of cfDNA. As a result, determining the cell type origins of cfDNA molecules can provide information about an individual's health...
journal article 2023
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le Poole, J.J. (author), Duchateau, E.A.E. (author), Hopman, J.J. (author), Kana, A.A. (author)
Design rationale is a promising way of capturing design decisions and considerations for later retrieval and traceability to improve collaborative design decision-making. To achieve these perceived benefits for early-stage complex ship design, this paper first elaborates on the development of a proof-of-concept design rationale method. The...
journal article 2023
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Zhang, M. (author), Bouland, G.A. (author), Holstege, H. (author), Reinders, M.J.T. (author)
Background and Objectives - With age, somatic mutations accumulated in human brain cells can lead to various neurologic disorders and brain tumors. Because the incidence rate of Alzheimer disease (AD) increases exponentially with age, investigating the association between AD and the accumulation of somatic mutation can help understand the...
journal article 2023
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Postema, R.R. (author), Hardon, S.F. (author), Cefai, David (author), Dankelman, J. (author), Jansen, F.W. (author), Camenzuli, Christian (author), Calleja-Agius, Jean (author), Horeman, T. (author)
Background: <br/>Veress needles (VN) are commonly used in establishing pneumoperitoneum in laparoscopic surgery. Previously, a VN with a new safety mechanism ‘VeressPLUS’ needle (VN+) was developed to reduce the amount of overshoot.<br/><br/>Methods: <br/>Eighteen participants (novices, intermediates, and experts) performed in total of 248...
journal article 2023
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Copeland, S.M. (author), Hinrichs-Krapels, S. (author), Fecondo, Federica (author), Santizo, Esteban Ralon (author), Bal, Roland (author), Comes, M. (author)
BACKGROUND: Prompted by recent shocks and stresses to health systems globally, various studies have emerged on health system resilience. Our aim is to describe how health system resilience is operationalised within empirical studies and previous reviews. We compare these to the core conceptualisations and characteristics of resilience in a...
journal article 2023
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Biharie, K. (author), Michielsen, L.C.M. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Motivation: Knowing the relation between cell types is crucial for translating experimental results from mice to humans. Establishing cell type matches, however, is hindered by the biological differences between the species. A substantial amount of evolutionary information between genes that could be used to align the species is discarded by...
journal article 2023
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Zhang, X. (author), Broere, W. (author)
The short-term deformation behavior of immersed tunnels due to daily or monthly temperature changes and tidal variations is often not monitored but forms important input for a structural health assessment of the tunnel. In this study, distributed optical fiber sensors (DOFSs) are used to monitor the short-term (daily and monthly) deformation...
journal article 2023
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Faber, J.S. (author), Al-Dhahir, Isra (author), Kraal, J.J. (author), Breeman, Linda D. (author), Reijnders, Thomas (author), van Dijk, S. (author), Visch, V.T. (author), Chavannes, N.H. (author), Evers, A.W.M. (author)
BACKGROUND: People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities....
journal article 2023
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Devia Pinzon, C.A. (author), Giordano, G. (author)
We propose an agent-based opinion formation model characterised by a two-fold novelty. First, we realistically assume that each agent cannot measure the opinion of its neighbours about a given statement with infinite resolution and accuracy, and hence it can only perceive the opinion of others as agreeing much more, or more, or comparably, or...
journal article 2023
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Geleijnse, J. (author), Rutten, M.M. (author), de Villiers, D.J. (author), Bamwenda, James Tayebwa (author), Abraham, E. (author)
Monitoring safe water access in developing countries relies primarily on household health survey and census data. These surveys are often incomplete: they tend to focus on the primary water source only, are spatially coarse, and usually happen every 5-10 years, during which significant changes can happen in urbanisation and infrastructure...
journal article 2023
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Hobeika, N. (author), van Rijssel, L.N. (author), Prusti, M.K. (author), Dinklo, C.J.T. (author), Giannelli, D. (author), Dukai, B. (author), Kok, Arnaud (author), van Loon, Rob (author), Nota, René (author), Stoter, J.E. (author)
Noise simulations are an important part of noise studies that investigate the impact of noise sources on the environment. In noise simulation, noise levels at receiver points are calculated based on the noise propagation paths between the receiver and source points. These paths are derived from the height of the terrain. In current calculation...
journal article 2023
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Kitsak, M.A. (author), Ganin, Alexander (author), Elmokashfi, Ahmed (author), Cui, Hongzhu (author), Eisenberg, Daniel A. (author), Alderson, David L. (author), Korkin, Dmitry (author), Linkov, Igor (author)
Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are a plethora of computational algorithms for...
journal article 2023
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Janssens, M. (author), Vilà-Guerau de Arellano, Jordi (author), van Heerwaarden, Chiel C. (author), van Stratum, Bart J.H. (author), de Roode, S.R. (author), Siebesma, A.P. (author), Glassmeier, F. (author)
Numerical simulations of the tropical mesoscales often exhibit a self-reinforcing feedback between cumulus convection and shallow circulations, which leads to the self-aggregation of clouds into large clusters. We investigate whether this basic feedback can be adequately captured by large-eddy simulations (LESs). To do so, we simulate the non...
journal article 2023
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de Jong, M.H.J. (author), Ganesan, Adarsh (author), Cupertino, A. (author), Groeblacher, S. (author), Norte, R.A. (author)
Mechanical frequency combs are poised to bring the applications and utility of optical frequency combs into the mechanical domain. So far, their main challenge has been strict requirements on drive frequencies and power, which complicate operation. We demonstrate a straightforward mechanism to create a frequency comb consisting of mechanical...
journal article 2023
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Callens, S.J.P. (author), Fan, D. (author), van Hengel, I.A.J. (author), Minneboo, M.B. (author), Diaz Payno, P.J. (author), Stevens, Molly M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, and tissue formation. However, it remains largely unclear how cells collectively explore and pattern complex landscapes with curvature gradients across the Euclidean and non-Euclidean spectra. Here, we show that...
journal article 2023
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Ceron Chafla, P.S. (author), de Vrieze, Jo (author), Rabaey, Korneel (author), van Lier, J.B. (author), Lindeboom, R.E.F. (author)
Background: Elevated CO<sub>2</sub> partial pressure (pCO<sub>2</sub>) has been proposed as a potential steering parameter for selective carboxylate production in mixed culture fermentation. It is anticipated that intermediate product spectrum and production rates, as well as changes in the microbial community, are (in)directly influenced by...
journal article 2023
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Hartel, P.H. (author), van Wegberg, R.S. (author)
Law enforcement agencies struggle with criminals using end-to-end encryption (E2EE). A recent policy paper states: “while encryption is vital and privacy and cyber security must be protected, that should not come at the expense of wholly precluding law enforcement”. The main argument is that E2EE hampers attribution and prosecution of...
journal article 2023
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Pols, C.F.J. (author), Dekkers, P.J.J.M. (author), de Vries, M.J. (author)
This small-scale, qualitative study uses educational design research to explore how focusing on argumentation may contribute to students’ learning to engage in inquiry independently. Understanding inquiry as the construction of a scientifically cogent argument in support of a claim may encourage students to develop personal reasons for adhering...
journal article 2023
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Aleebrahimdehkordi, M. (author), Lechner, J.M. (author), Ghorbani, Amineh (author), Nikolic, I. (author), Chappin, E.J.L. (author), Herder, P.M. (author)
Agent-based modelling and simulation (ABMS), whether simple toy models or complex data-driven ones, is regularly applied in various domains to study the system-level patterns arising from individual behaviour and interactions. However, ABMS still faces diverse challenges such as modelling more representative agents or improving computational...
journal article 2023
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de Wit, J. (author), Glentis, George Othon (author), Kalkman, J. (author)
Phase-preserving spectral estimation optical coherence tomography (SE-OCT) enables combining axial resolution improvement with computational depth of field (DOF) extension. We show that the combination of SE-OCT with interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) results in high 3D resolution over...
journal article 2023
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