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A novel viral infection model to guide optimal mpox treatment

de Jong, M.N. (author), Campana, Francesca Cala (author), Li, Pengfei (author), Pan, Qiuwei (author), Giordano, G. (author)

In 2022, worldwide mpox outbreaks have called attention to mpox virus infection and treatment opportunities using the drugs cidofovir and tecovirimat, which target different stages of in-host viral proliferation, respectively production and shedding. We propose a new model of in-host viral infection dynamics that distinguishes between the two...

journal article 2023

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Membrane proteome of the thermoalkaliphile Caldalkalibacillus thermarum TA2.A1

de Jong, S.I. (author), Sorokin, Dimitry Y. (author), van Loosdrecht, Mark C.M. (author), Pabst, Martin (author), McMillan, D.G.G. (author)

Proteomics has greatly advanced the understanding of the cellular biochemistry of microorganisms. The thermoalkaliphile Caldalkalibacillus thermarum TA2.A1 is an organism of interest for studies into how alkaliphiles adapt to their extreme lifestyles, as it can grow from pH 7.5 to pH 11. Within most classes of microbes, the membrane-bound...

journal article 2023

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Tuning the Properties of N-Doped Biochar for Selective CO₂ Electroreduction to CO

Fu, S. (author), Li, M. (author), de Jong, W. (author), Kortlever, R. (author)

Nitrogen-doped (N-doped) carbon catalysts have been widely studied for electrochemical CO₂ reduction to CO. However, the correlation between the physicochemical properties of N-doped carbon catalysts and their electrocatalytic performance for the CO₂RR is still unclear. Herein, a series of N-doped biochar catalysts with...

journal article 2023

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Unlocking system transitions for municipal solid waste infrastructure: A model for mapping interdependencies in a local context

Liu, Z. (author), Schraven, D.F.J. (author), de Jong, Martin (author), Hertogh, M.J.C.M. (author)

Rapid global urbanization, urban renewal and changes in people's lifestyles have led to both an increase in waste generation and more complex waste types. In response to these changes, many local governments have invested in municipal solid waste infrastructure (MSWI) to implement circular strategies. However, matching and bridging the costly...

journal article 2023

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4D Flow Patterns and Relative Pressure Distribution in a Left Ventricle Model by Shake-the-Box and Proper Orthogonal Decomposition Analysis

Wu, X. (author), Saaid, Hicham (author), Voorneveld, J.D. (author), Claessens, Tom (author), Westenberg, Jos J.M. (author), de Jong, N. (author), Bosch, Johan G. (author), Kenjeres, S. (author)

Purpose: Intraventricular blood flow dynamics are associated with cardiac function. Accurate, noninvasive, and easy assessments of hemodynamic quantities (such as velocity, vortex, and pressure) could be an important addition to the clinical diagnosis and treatment of heart diseases. However, the complex time-varying flow brings many...

journal article 2023

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Hydrothermal liquefaction of Elaeis guineensis trunks: Lessons learned from a case study in Guatemala

Cutz, L. (author), Maldonado de León, H.A. (author), Zambrano, Gamaliel (author), Al-Naji, Majd (author), de Jong, W. (author)

The oil palm industry has been under public scrutiny during the last decades due to environmental and social issues related to its practices. Oil palm (Elaeis guineensis Jacq.) trunks (OPTs) are of special interest as they are left idle in the field after the replanting process which is performed every 25 years. This common practice results...

journal article 2023

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High-Frame-Rate Volumetric Porcine Renal Vasculature Imaging

Wei, Luxi (author), Wahyulaksana, G. (author), Boni, Enrico (author), Noothout, E.C. (author), Duncker, Dirk J. (author), Tortoli, Piero (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Vos, H.J. (author)

Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with...

journal article 2023

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Effects of fir-wood biochar on CH4 oxidation rates and methanotrophs in landfill cover soils packed at three different proctor compaction levels

Buisma-Yi, S.C. (author), Heijbroek, A.C. (author), Cutz, L. (author), Pillay, S. (author), de Jong, W. (author), Abeel, T.E.P.M.F. (author), Gebert, J. (author)

Application of biochar to landfill cover soils can purportedly improve methane (CH4) oxidation rates, but understanding the combined effects of soil texture, compaction, and biochar on the activity and composition of the methanotrophs is limited. The amendment of wood biochar on two differently textured landfill cover soils at three compaction...

journal article 2023

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Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Caenen, Annette (author), Keijzer, Lana (author), Bézy, Stéphanie (author), Duchenne, Jürgen (author), Orlowska, Marta (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Voigt, Jens Uwe (author), D’hooge, Jan (author), Vos, H.J. (author)

Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple...

journal article 2023

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A multibody kinematic system approach for the design of shape-morphing mechanism-based metamaterials

de Jong, P.H. (author), Schwab, A.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Shape-morphing structures have the ability to adapt to various target shapes, offering significant advantages for many applications. However, predicting their behavior presents challenges. Here, we present a method to assess the shape-matching behavior of shape-morphing structures using a multibody systems approach wherein the structure is...

journal article 2023

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Controllable Single Cooper Pair Splitting in Hybrid Quantum Dot Systems

de Jong, D. (author), Prosko, C.G. (author), Han, L. (author), Malinowski, F.K. (author), Liu, Yu (author), Kouwenhoven, Leo P. (author), Pfaff, Wolfgang (author)

Cooper pair splitters hold utility as a platform for investigating the entanglement of electrons in Cooper pairs, but probing splitters with voltage-biased Ohmic contacts prevents the retention of electrons from split pairs since they can escape to the drain reservoirs. We report the ability to controllably split and retain single Cooper...

journal article 2023

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The societal strength of transition: a critical review of the circular economy through the lens of inclusion

Liu, Z. (author), Schraven, D.F.J. (author), de Jong, Martin (author), Hertogh, M.J.C.M. (author)

Realizing a circular economy (CE) has been widely recognized by practitioners and researchers as the key to the transition toward sustainability. Thus far the academic emphasis has been predominantly on economic and environmental aspects. However, the development and implementation of CE initiatives actually rely on extensive collaboration at...

journal article 2023

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Using salt marshes for coastal protection: Effective but hard to get where needed most

Marin-Diaz, Beatriz (author), van der Wal, Daphne (author), Kaptein, Leon (author), Martinez-Garcia, Pol (author), Lashley, Christopher H. (author), de Jong, Kornelis (author), Nieuwenhuis, Jan Willem (author), Govers, Laura L. (author), Olff, Han (author), Bouma, Tjeerd J. (author)

Salt marshes fronting coastal structures, such as seawalls and dikes, may offer important ecosystem-based coastal defence by reducing the wave loading and run-up levels during storms. We question (i) how the long-term salt marsh development in the Dutch Wadden Sea relates to the tidal-flat foreshore bathymetry and (ii) how the wave run-up...

journal article 2023

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Differences in levels of accessibility: The importance of spatial scale when measuring distributions of the accessibility of health and emergency services

van Wee, G.P. (author), de Jong, Tom (author)

This paper explores to what extent inequalities in travel times, measured via the Gini index, depend on the spatial scale at which (average) travel times are measured. By using the new concept of Dedicated Accessibility Points, for the Netherlands we calculated average travel times at four spatial levels, ranging from virtually individual...

journal article 2023

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Intra-renal microcirculatory alterations on non-traumatic hemorrhagic shock induced acute kidney injury in pigs

Ergin, Bülent (author), van Rooij, Tom (author), Lima, Alex (author), Ince, Yasin (author), Specht, Patricia Ac (author), Mik, E.G. (author), Aksu, Ugur (author), Yavuz-Aksu, Berna (author), de Jong, N. (author)

Acute kidney injury (AKI) is frequently seen in patients with hemorrhagic shock due to hypotension, tissue hypoxia, and inflammation despite adequate resuscitation. There is a lack of information concerning the alteration of renal microcirculation and perfusion during shock and resuscitation. The aim of this study was to investigate the...

journal article 2023

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Development of a simulator for training of fetoscopic myelomeningocele surgery

Spoor, Jochem K.H. (author), van Gastel, Lis (author), Tahib, Fatima (author), van Grieken, Amanda (author), van Weteringen, Willem (author), Sterke, F. (author), Baschat, Ahmet A. (author), Miller, Jena L. (author), de Jong, Tjeerd H.R. (author), Wijnen, René M.H. (author), Eggink, Alex E. (author), DeKoninck, Philip L.J. (author)

Objective: To develop a realistic simulation model for laparotomy-assisted fetoscopic spina bifida aperta (SBa) surgery, to be used for training purposes and preoperative planning. Methods: The predefined general requirement was a realistic model of an exteriorized uterus, allowing all neurosurgical steps of the intervention. The uterus was...

journal article 2023

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A 1.2-mW/Channel Pitch-Matched Transceiver ASIC Employing a Boxcar-Integration-Based RX Micro-Beamformer for High-Resolution 3-D Ultrasound Imaging

Guo, P. (author), Fool, F. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)

This article presents a low-power and small-area transceiver application-specific integrated circuit (ASIC) for 3-D trans-fontanelle ultrasonography. A novel micro-beamforming receiver architecture that employs current-mode summation and boxcar integration is used to realize delay-and-sum on an N -element sub-array using N× fewer capacitive...

journal article 2023

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Ultrasonic Characterization of Ibidi μ-Slide I Luer Channel Slides for Studies With Ultrasound Contrast Agents

Zangabad, Reza Pakdaman (author), Li, H. (author), Kouijzer, Joop J.P. (author), Langeveld, Simone A.G. (author), Beekers, Ines (author), Verweij, M.A. (author), de Jong, N. (author), Kooiman, Klazina (author)

Understanding and controlling the ultrasound contrast agent (UCA)'s response to an applied ultrasound pressure field are crucial when investigating ultrasound imaging sequences and therapeutic applications. The magnitude and frequency of the applied ultrasonic pressure waves affect the oscillatory response of the UCA. Therefore, it is...

journal article 2023

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ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria

Krah, Alexander (author), Vogelaar, Timothy (author), de Jong, S.I. (author), Claridge, Jolyon K. (author), Bond, Peter J. (author), McMillan, D.G.G. (author)

It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix probing into the central architecture of the hexameric catalytic domain, preventing ATP hydrolysis. The ε subunit takes a contracted...

journal article 2023

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Variable and Orbital-Dependent Spin-Orbit Field Orientations in an InSb Double Quantum Dot Characterized via Dispersive Gate Sensing

Han, L. (author), Chan, M. (author), de Jong, D. (author), Prosko, C.G. (author), Badawy, Ghada (author), Gazibegovic, Sasa (author), Bakkers, Erik P.A.M. (author), Kouwenhoven, Leo P. (author), Malinowski, F.K. (author), Pfaff, Wolfgang (author)

Utilizing dispersive gate sensing (DGS), we investigate the spin-orbit field (BSO) orientation in a many-electron double quantum dot (DQD) defined in an InSb nanowire. While characterizing the interdot tunnel couplings, we find the measured dispersive signal depends on the electron-charge occupancy, as well as on the amplitude and orientation...

journal article 2023