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Song, B. (author), Schneider, G.F. (author), Xu, Q. (author), Pandraud, G. (author), Dekker, C. (author), Zandbergen, H. (author)
Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
journal article 2011
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Lipfert, J. (author), Kerssemakers, J.J.W. (author), Rojer, M. (author), Dekker, N.H. (author)
The double helical nature of DNA links many cellular processes such as DNA replication, transcription, and repair to rotational motion and the accumulation of torsional strain. Magnetic tweezers (MTs) are a single-molecule technique that enables the application of precisely calibrated stretching forces to nucleic acid tethers and to control...
journal article 2011
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Dekker, K. (author), De Bruyne, E. (author), Gosselink, A.M. (author), Pullen, W.R. (author), Le Roux, P. (author)
report 2011
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Holthausen, J.T. (author), Van Loenhout, M.T.J. (author), Sanchez, H. (author), Ristic, D. (author), Van Rossum-Fikkert, S.E. (author), Modesti, M. (author), Dekker, C. (author), Kanaar, R. (author), Wyman, C. (author)
Homologous recombination is essential for the preservation of genome stability, thereby preventing cancer. The recombination protein RAD51 drives DNA strand exchange, which requires the assembly, rearrangement and disassembly of a RAD51 filament on DNA, coupled to ATP binding and hydrolysis. This process is facilitated and controlled by...
journal article 2011
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Dekker, K. (author), Kleinhans, R. (author)
This paper focuses on the relationship between voluntary and involuntary reasons for relocation, and the satisfaction with the dwelling and the neighbourhood. We distinguish between voluntary reasons to move and forced reasons to move (demolition or renovation versus divorce). While these separate reasons have been extensively studied in the...
conference paper 2010
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Lipfert, J. (author), Klijnhout, S. (author), Dekker, N.H. (author)
DNA-binding small molecules are widespread in the cell and heavily used in biological applications. Here, we use magnetic tweezers, which control the force and torque applied to single DNAs, to study three small molecules: ethidium bromide (EtBr), a well-known intercalator; netropsin, a minor-groove binding anti-microbial drug; and topotecan, a...
journal article 2010
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Van Gent, I. (author), Dekker, S. (author)
journal article 2010
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Dekker, S. (author), De Graaf, M. (author), Van Houten, D. (author), Van Ettinger, A. (author)
journal article 2010
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Dekker, R (author), Kleinknecht, A.H. (author), Zhou, H (author)
Firms with high shares of workers on fixed-term contracts have significantly higher sales of imitative new products but perform significantly worse on sales of innovative new products (“first on the market”). High functional flexibility in “insider-outsider” labor markets enhances a firm’s new product sales, as do training efforts and highly...
working paper 2010
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Van Ettinger, A. (author), Dekker, S. (author)
journal article 2010
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De Vlaminck, I. (author), Vidic, I. (author), Van Loenhout, M.T.J. (author), Kanaar, R. (author), Lebbink, J.H.G. (author), Dekker, C. (author)
All cellular single-stranded (ss) DNA is rapidly bound and stabilized by single stranded DNA-binding proteins (SSBs). Replication protein A, the main eukaryotic SSB, is able to unwind double-stranded (ds) DNA by binding and stabilizing transiently forming bubbles of ssDNA. Here, we study the dynamics of human RPA (hRPA) activity on topologically...
journal article 2010
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Van den Hout, M. (author), Hall, A.R. (author), Wu, M.Y. (author), Zandbergen, H.W. (author), Dekker, C. (author), Dekker, N.H. (author)
Solid-state nanopores are considered a promising tool for the study of biological polymers such as DNA and RNA, due largely to their flexibility in size, potential in device integration and robustness. Here, we show that the precise shape of small nanopores (?5 nm diameter in 20 nm SiN membranes) can be controlled by using transmission electron...
journal article 2010
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Dujovne, I. (author), Kerssemakers, J. (author), Capello, G. (author), Dekker, C. (author)
We present a novel high-resolution technique for single-molecule experiments, viz., differential traveling wave tracking. This is an interference-based scattering technique where we use gold nanoparticles for high scattering intensities and incorporate differential measurements along one in-plane direction to subtract mechanical noise and drift...
journal article 2010
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Smeets, R.M.M. (author), Dekker, N.H. (author), Dekker, C. (author)
Low-frequency ionic current noise in solid-state nanopores imposes a limitation on the time resolution achieved in translocation experiments. Recently, this 1/ f noise was described as obeying Hooge’s phenomenological relation, where the noise scales inversely with the number of charge carriers present. Here, we consider an alternative model in...
journal article 2009
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Qu, Z. (author), Aravind, P.V. (author), Ye, H. (author), Dekker, N.J.J. (author), Woudstra, N. (author), Verkooijen, A.H.M. (author)
This paper presents a three-dimensional model of an anode-supported planar SOFC with corrugated bipolar plates serving as gas channels and current collector above the active area of the cell, based on the direct internal reforming reaction of methane and the electrochemical reaction of hydrogen. A co-flow system with gas mixture of methane,...
journal article 2009
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Qu, Z. (author), Aravind, P.V. (author), Ye, H. (author), Dekker, N.J.J. (author), Woudstra, N. (author), Verkooijen, A.H.M. (author)
journal article 2009
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Männik, J. (author), Driessen, R. (author), Galajda, P. (author), Keymer, J.E. (author), Dekker, C. (author)
In many naturally occurring habitats, bacteria live in micrometer-size confined spaces. Although bacterial growth and motility in such constrictions is of great interest to fields as varied as soil microbiology, water purification, and biomedical research, quantitative studies of the effects of confinement on bacteria have been limited. Here, we...
journal article 2009
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Van Loenhout, M.T.J. (author), Van der Heijden, T. (author), Kanaar, R. (author), Wyman, C. (author), Dekker, C. (author)
RecA, the key protein in homologous recombination, performs its actions as a helical filament on single-stranded DNA (ssDNA). ATP hydrolysis makes the RecA–ssDNA filament dynamic and is essential for successful recombination. RecA has been studied extensively by single-molecule techniques on double-stranded DNA (dsDNA). Here we directly probe...
journal article 2009
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Kleinknecht, A. (author), Dekker, R. (author), Zhou, H. (author)
Firms with high shares of workers on fixed-term contracts have significantly higher sales of imitative new products but perform significantly worse on sales of innovative new products (“first on the market”). High functional flexibility in “insider-outsider” labor markets enhances a firm’s new product sales, as do training efforts and highly...
journal article 2009
document
Dekker, N. (author)
public lecture 2009
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