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Meijer, D.H.M. (author), Pereira Frias, C.S. (author), Beugelink, J. Wouter (author), Deurloo, Y.N. (author), Janssen, Bert J.C. (author)
Establishment of correct synaptic connections is a crucial step during neural circuitry formation. The Teneurin family of neuronal transmembrane proteins promotes cell–cell adhesion via homophilic and heterophilic interactions, and is required for synaptic partner matching in the visual and hippocampal systems in vertebrates. It remains...
journal article 2022
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Bernstein, Michael J. (author), Nielsen, Mathias Wullum (author), Alnor, Emil (author), Brasil, André (author), Birkving, Astrid Lykke (author), Chan, Tung Tung (author), Griessler, Erich (author), de Jong, Stefan (author), van de Klippe, Wouter (author), Meijer, Ingeborg (author), Yaghmaei, E. (author), Nicolaisen, Peter Busch (author), Nieminen, Mika (author), Novitzky, Peter (author), Mejlgaard, Niels (author)
In this paper, we introduce the Societal Readiness (SR) Thinking Tool to aid researchers and innovators in developing research projects with greater responsiveness to societal values, needs, and expectations. The need for societally-focused approaches to research and innovation—complementary to Technology Readiness (TR) frameworks—is presented....
journal article 2022
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Kerry, T.J. (author), Peters, A.G.A. (author), Georgakopoulos, E. (author), Dugulan, A.I. (author), Meijer, Koen (author), Hage, Johannes (author), Offerman, S.E. (author), Yang, Y. (author)
Within the steelmaking industry, a large amount of zinc-bearing waste is produced which cannot be effectively treated through integrated steel mills. Concurrently, zinc smelters generate waste residues containing significant amounts of iron and zinc which are stored or landfilled. The zinc concentration of iron and steelmaking residues...
journal article 2022
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van Stijn, A. (author), Eberhardt, L. C.M. (author), Jansen, B. (author), Meijer, A. (author)
The transition towards a Circular Economy (CE) in the built environment is vital to reduce environmental impacts, resource consumption and waste generation. The built environment can be made circular by replacing building components with more circular ones. There are many circular design options for building components and knowledge about...
journal article 2022
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Hosseini, A. (author), Georgakopoulos, E. (author), Dihman, Vinod (author), Hage, Johannes (author), Meijer, Koen (author), Zeilstra, Christiaan (author), Offerman, S.E. (author), Yang, Y. (author)
Galvanized steel scrap flow and injection into the HIsarna reactor are investigated using discrete element method (DEM). The scrap particle is fed into the reactor through an inclined chute and hits the slag surface where the zinc content is evaporated and solid particles melt. A DEM model is setup and validated using experimental data...
journal article 2022
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Kalisvaart, Gijsbert M. (author), van Velden, Floris H.P. (author), Hernández-Girón, Irene (author), Meijer, Karin M. (author), Ghesquiere-Dierickx, Laura M.H. (author), Brink, Wyger M. (author), Webb, A. (author), de Geus-Oei, Lioe-Fee (author), Slump, Cornelis H. (author), Kuznetsov, D.V. (author), Schaart, D.R. (author), Grootjans, Willem (author)
Background: Accuracy and precision assessment in radiomic features is important for the determination of their potential to characterize cancer lesions. In this regard, simulation of different imaging conditions using specialized phantoms is increasingly being investigated. In this study, the design and evaluation of a modular multimodality...
journal article 2022
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Georgakopoulos, E. (author), Hosseini, A. (author), Kerry, T.J. (author), Hage, Johannes (author), Meijer, Koen (author), Offerman, S.E. (author), Yang, Y. (author)
HIsarna is a novel ironmaking process with great raw materials versatility that is attractive for various secondary resources. Among the materials that can be recycled, there is steel scrap which is fed to the furnace bath through an inclined chute. The velocity distribution of the scrap particles along the chute affects the particles’...
journal article 2022
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Hosseini, A. (author), Hage, Johannes L.T. (author), Duiker, Arjan (author), Meijer, Koen (author), Peeters, Tim (author), Offerman, S.E. (author), Yang, Y. (author)
For all industrial applications, predicting system characteristics and behavior plays a vital role before constructing costly and complex multi-physic systems. Correct and reliable predictions become even more important once the aim is to go from small- to large-scale processes to establish an industrial demonstrations. In this study, a CFD...
journal article 2022
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van der Bent, H.S. (author), Meijer, A. (author), Visscher, H.J. (author), Mouter, N. (author)
Benchmarking is a method that can be used to measure progress and create awareness about the performance of organisations. Benchmarking the housing stock energy performance of Dutch housing associations can be used to measure and assess progress towards the decarbonisation of the housing stock. A new national climate agreement was signed in...
journal article 2022
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Meijer, Simone (author), van Middendorp, Henriët (author), Peerdeman, Kaya J. (author), Evers, A.W.M. (author)
Persistent physical symptoms have a high prevalence and a large impact for patients and society. To date, treatment effects for these symptoms are often limited. Nocebo effects (i.e., negative outcomes that are not attributable to active treatment components) have a substantial influence on treatment success and can be established via...
journal article 2022
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Wentinck, Koen (author), Gogou, C. (author), Meijer, D.H.M. (author)
Significant advances in the past decade have enabled high-resolution structure determination of a vast variety of proteins by cryogenic electron microscopy single particle analysis. Despite improved sample preparation, next-generation imaging hardware, and advanced single particle analysis algorithms, small proteins remain elusive for...
review 2022
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Chataigner, Lucas M.P. (author), Gogou, C. (author), den Boer, Maurits A. (author), Pereira Frias, C.S. (author), Thies-Weesie, Dominique M.E. (author), Granneman, Joke C.M. (author), Heck, Albert J.R. (author), Meijer, D.H.M. (author), Janssen, Bert J.C. (author)
Cell-surface expressed contactin 1 and neurofascin 155 control wiring of the nervous system and interact across cells to form and maintain paranodal myelin-axon junctions. The molecular mechanism of contactin 1 – neurofascin 155 adhesion complex formation is unresolved. Crystallographic structures of complexed and individual contactin 1 and...
journal article 2022
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Wortel, Meike T. (author), Agashe, Deepa (author), Bailey, Susan F. (author), Bank, Claudia (author), Bisschop, Karen (author), Blankers, Thomas (author), Laan, L. (author), Meijer, Jeroen (author), Tans, S.J. (author)
Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine, agriculture, biotechnology and conservation biology. Evolutionary predictions may be used for...
review 2022
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Meijer, D.H. (author), Korving, Hans (author), Clemens-Meyer, François (author)
Hydrodynamic models are used to analyse water networks (water distribution, drainage, surface water, district heating, etc.). The non-linear nature of water flows necessitates the use of iterative solution methods in hydraulic modelling. This requires a relatively large computational effort. To reduce this effort, networks, network forcing...
journal article 2022
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Meijer, F.M. (author), Straub, A. (author)
Dutch policies to reach a CO2 neutral housing stock in 2050 force housing associations to realise higher renovation rates at lower costs. The potential for standardisation in renovation processes of the housing stock is huge. Practice shows that an increasing number of housing associations bundle their individual maintenance and sustainable...
journal article 2022
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Fraser, Alan (author), Nelissen, R.G.H.H. (author), Kjærsgaard-Andersen, P. (author), Szymański, P. (author), Melvin, T. (author), Piscoi, P. (author), Fraser, Alan (author), Szymański, Piotr (author), Gale, Chris (author), Maggioni, Aldo (author), Zanon, Elisabetta (author), Dimopoulou, Christina (author), Ceccarelli, Cinzia (author), Vairami, Polyxeni (author), Ruszanov, Anett (author), Kjærsgaard-Andersen, Per (author), Nelissen, Rob (author), Ott, Adrian (author), Macintyre, Elizabeth (author), Simulescu, Loredana (author), Meijer, Marieke (author), Koletzko, Berthold (author), Wieczorek, Sarah (author), Hadjipanayis, Adamos (author), Del Torso, Stefano (author), Marang-van de Mheen, P.J. (author), Hoogervorst, L. (author), Steyerberg, Ewout W. (author), de Vries, B. (author), McCulloch, Peter (author), Landray, Martin (author), Alhambra, Daniel Prieto (author), Smith, James (author), Lubbeke-Wolf, Anne (author), James, Stefan (author), Buccheri, Sergio (author), Byrne, Robert (author), McGovern, Laurna (author), Windecker, Stephan (author), Frenk, Andre (author), Siontis, Georgios (author), Stettler, Christoph (author), Bano, Arjola (author), Bally, Lia (author), Rademakers, Frank E. (author), D'hooge, Jan (author), Vedder, Anton (author), Biasin, Elisabetta (author), Kamenjasevic, Erik (author), Schnell-Inderst, Petra (author)
In the European Union (EU) the delivery of health services is a national responsibility but there are concerted actions between member states to protect public health. Approval of pharmaceutical products is the responsibility of the European Medicines Agency, whereas authorizing the placing on the market of medical devices is decentralized to...
journal article 2022
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van der Bent, H.S. (author), Visscher, H.J. (author), Meijer, A. (author), Mouter, N. (author)
The Energy Performance of Buildings Directive (EPBD) enhanced the sustainable improvement of dwellings in the European Union. Member states formulated measurable goals to improve the housing stock, and monitoring systems were developed to give insights into the improvements. In the Netherlands, non-profit housing associations agreed to improve...
journal article 2021
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Meijer, Niels (author), Dupont-Nivet, Guillaume (author), Barbolini, Natasha (author), Woutersen, Amber (author), Rohrmann, Alexander (author), Zhang, Yang (author), Liu, Xiang Jun (author), Licht, Alexis (author), Abels, H.A. (author)
Asian mineral dust has been studied extensively for its role in affecting regional-to global-scale climate and for its deposits, which enable reconstructing Asian atmospheric circulation in the past. However, the timing and origin of the dust deposits remain debated. Numerous loess records have been reported across the Asian continent with...
journal article 2021
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Bauduin, S.E.E.C. (author), den Rooijen, I.L.B. (author), Meijer, M. (author), van der Werff, S.J.A. (author), Keo, D.L. (author), Dzyubachyk, O. (author), Pereira, A.M. (author), Giltay, E.J. (author), van der Wee, N.J.A. (author), Meijer, O.C. (author), Mahfouz, A.M.E.T.A. (author)
Introduction: Cushing's disease (CD) is a rare and severe endocrine disease characterized by hypercortisolemia. Previous studies have found structural brain alterations in remitted CD patients compared to healthy controls, specifically in the anterior cingulate cortex (ACC). However, potential mechanisms through which these persistent...
journal article 2021
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van der Bent, H.S. (author), van den Brom, P.I. (author), Visscher, H.J. (author), Meijer, A. (author), Mouter, N. (author)
In Europe, the energy performance of dwellings is measured using theoretical building energy models based on the Energy Performance of Buildings Directive (EPBD), which estimates the energy consumption of dwellings. However, literature shows large performance gaps between the theoretically predicted energy consumption and the actual energy...
journal article 2021
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