- document
-
De Groot, M.J.L. (author), Van Berlo, R.J.P. (author), Van Winden, W.A. (author), Verheijen, P.J.T. (author), Reinders, M.J.T. (author), De Ridder, D. (author)Motivation: Many enzymes are not absolutely specific, or even promiscuous: they can catalyze transformations of more compounds than the traditional ones as listed in e.g. KEGG. This information is currently only available in databases, such as the BRENDA enzyme activity database. In this paper, we propose to model enzyme aspecificity by...journal article 2009
- document
-
Vastenburg, M.H. (author), Keyson, D.V. (author), De Ridder, H. (author)Recent field experiments on acceptability of notifications in the home showed that people generally want to be informed of urgent messages as soon as possible, whereas non-urgent messages should not be presented at all. A possible way to improve the acceptability of a notification might be to adjust the presentation mode and the timing of...journal article 2009
- document
-
Ten Holt, G.A. (author), Arendsen, J. (author), De Ridder, H. (author), Van Doorn, A.J. (author), Reinders, M.J.T. (author), Hendriks, E.A. (author)Current automatic sign language recognition (ASLR) seldom uses perceptual knowledge about the recognition of sign language. Using such knowledge can improve ASLR because it can give an indication which elements or phases of a sign are important for its meaning. Also, the current generation of data-driven ASLR methods has shortcomings which may...conference paper 2009
- document
-
De Ridder, H. (author), De Ridder-Sluiter, J.G. (author), Kluin, P.M. (author), Christiaans, H.H.C.M. (author)Ubiquitous computing (or Ambient Intelligence) is an upcoming technology that is usually associated with futuristic smart environments in which information is available anytime anywhere and with which humans can interact in a natural, multimodal way. However spectacular the corresponding scenarios may be, it is equally challenging to consider...conference paper 2009
- document
-
Van Egmond, R. (author), Lemmens, P. (author), Pappas, T.N. (author), De Ridder, H. (author)In three experiments the perceived roughness of visual and of auditory materials was investigated. In Experiment 1, the roughness of frequency-modulated tones was determined using a paired-comparison paradigm. It was found that using this paradigm similar results in comparison to literature were found. In Experiment 2, the perceived visual...conference paper 2009
- document
-
Van Nes, P. (author), Bellomo, D. (author), Reinders, M.J.T. (author), De Ridder, D. (author)In recent work, attempts have been made to link the structure of biochemical networks to their complex dynamics. It was shown that structurally stable network motifs are enriched in such networks. In this work, we investigate to what extent these findings apply to metabolic networks. To this end, we extend a previously proposed method by...journal article 2009
- document
-
De Ridder, D. (author), Li, Y. (author), De Groot, M.J.L. (author), Reinders, M.J.T. (author)Comparative analysis of metabolic networks in multiple species yields important information on their evolution, and has great practical value in metabolic engineering, human disease analysis, drug design etc. In this work, we aim to systematically search for conserved pathways in two species, quantify their similarities, and focus on the...journal article 2008
- document
-
Hulsman, M. (author), Reinders, M.J.T. (author), De Ridder, D. (author)In recent years, more and more high-throughput data sources useful for protein complex prediction have become available (e.g., gene sequence, mRNA expression, and interactions). The integration of these different data sources can be challenging. Recently, it has been recognized that kernel-based classifiers are well suited for this task. However...journal article 2008
- document
-
Vermeeren, A.P.O.S. (author), Attema, J. (author), Akar, E. (author), De Ridder, H. (author), Van Doorn, A.J. (author), Erburg, Ç. (author), Berkman, A.E. (author), Maguire, M. (author)This study explores issues of consistency and inspectability in usability test data analysis processes and reports. Problem reports resulting from usability tests performed by three professional usability labs in three different countries are compared. Each of the labs conducted a usability test on the same product, applying a test protocol that...journal article 2008
- document
-
Rozendaal, M.C. (author), Keyson, D.V. (author), De Ridder, H. (author)A recent focus is on creating engaging user experiences with digital products and services such as voicemail. This study aims to design towards increased levels of engagement in voicemail browsing by using the ‘Richness, Control and Engagement’ (RC & E) framework. This framework explains the levels of engagement in terms of the levels of...journal article 2008
- document
-
De Ridder, H. (author), Rozendaal, M.C. (author)Ubiquitous computing (or Ambient Intelligence) promises a world in which information is available anytime anywhere and with which humans can interact in a natural, multimodal way. In such world, perceptual image quality remains an important criterion since most information will be displayed visually, but other criteria such as enjoyment, fun,...conference paper 2008
- document
-
Klijn, C.N. (author), Holstege, H. (author), De Ridder, J. (author), Liu, X. (author), Reinders, M. (author), Jonkers, J. (author), Wessels, L. (author)Tumor formation is in part driven by DNA copy number alterations (CNAs), which can be measured using microarray-based Comparative Genomic Hybridization (aCGH). Multiexperiment analysis of aCGH data from tumors allows discovery of recurrent CNAs that are potentially causal to cancer development. Until now, multiexperiment aCGH data analysis has...journal article 2008
- document
-
De Ridder, J. (author), Kool, J. (author), Uren, A. (author), Bot, J. (author), Wessels, L. (author), Reinders, M. (author)Motivation: Cancers are caused by an accumulation of multiple independent mutations that collectively deregulate cellular pathways, e.g. such as those regulating cell division and cell-death. The publicly available Retroviral Tagged Cancer Gene Database (RTCGD) contains the data of many insertional mutagenesis screens, in which the virally...journal article 2007
- document
-
Vastenburg, M.H. (author), Keyson, D.V. (author), De Ridder, H. (author)A field study in ten homes was conducted to understand what influences users’ acceptability of notifications in the home environment. The key finding is that perceived message urgency is the primary indicator of acceptability of notifications in the home—if people think a message is urgent, they want the message to be shown immediately,...journal article 2007
- document
-
De Ridder, G.J. (author)Philosophers of science have by and large neglected technology. In this book, I have tried to do something about this lacuna by analyzing a few aspects of technical artifacts from a philosophical angle. The project was part of the research program "The Dual Nature of Technical Artifacts" based at Delft University of Technology in the Netherlands...doctoral thesis 2007
- document
-
Albayrak, A. (author), Van Veelen, M.A. (author), Prins, J.F. (author), Snijders, C.J. (author), De Ridder, H. (author), Kazemier, G. (author)Background: One of the main ergonomic problems during surgical procedures is the surgeon's awkward body posture, often accompanied by repetitive movements of the upper extremities, increased muscle activity, and prolonged static head and back postures. In addition, surgeons perform surgery so concentrated that they tend to neglect their posture....journal article 2007
- document
- Buzink, S.N. (author), Koch, A.D. (author), Heemskerk, J. (author), Botden, S.M.B.I. (author), Goossens, R.H.M. (author), De Ridder, H. (author), Schoon, E.J. (author), Jakimowicz, J.J. (author) journal article 2007
- document
-
De Ridder, J. (author), Uren, A. (author), Kool, J. (author), Reinders, M. (author), Wessels, L. (author)Retroviral insertional mutagenesis screens, which identify genes involved in tumor development in mice, have yielded a substantial number of retroviral integration sites, and this number is expected to grow substantially due to the introduction of high-throughput screening techniques. The data of various retroviral insertional mutagenesis...journal article 2006
- document
- Verhaak, R.G.W. (author), Staal, F.J.T. (author), Valk, P.J.M. (author), Lowenberg, B. (author), Reinders, M.J.T. (author), De Ridder, D. (author) journal article 2006
- document
-
Van Doorn, A.J. (author), De Ridder, H. (author), Koenderink, J.J. (author)Pictorial relief depends strongly on “cues” in the image. For isoluminant renderings some cues are missing, namely all information that is related to luminance contrast (e.g., shading, atmospheric perspective). It has been suggested that spatial discrimination and especially pictorial space suffer badly in isoluminant conditions. We have...conference paper 2005