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Katan, A.J. (author), Dekker, C. (author)
Atomic force microscopy allows visualization of biomolecules with nanometer resolution under physiological conditions. Recent advances have improved the time resolution of the technique from minutes to tens of milliseconds, meaning that it is now possible to watch single biomolecules in action in real time. Here, we review this development.
journal article 2011
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van Noort, J. (author), van der Heijden, T. (author), Dutta, C.F. (author), Firman, K. (author), Dekker, C. (author)
journal article 2004
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Burnham, D.R. (author), De Vlaminck, I. (author), Henighan, T. (author), Dekker, C. (author)
Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response function for a single DNA molecule that is attached to the microsphere. The standard approach...
journal article 2014
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Kleinknecht, A. (author), Dekker, R. (author), Zhou, H. (author)
Firms with high shares of workers on fixed-term contracts have significantly higher sales of imitative new products but perform significantly worse on sales of innovative new products (“first on the market”). High functional flexibility in “insider-outsider” labor markets enhances a firm’s new product sales, as do training efforts and highly...
journal article 2009
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Joshi, S. (author), Savov, A.M. (author), Shafqat, Salman (author), Dekker, R. (author)
The authors found that oxygen plasma etching of polyimide (PI) with aluminum (Al) as a hard-etch mask results in lightly textured arbitrary shaped “fur-like” residues. Upon investigation, the presence of Al was detected in these residues. Ruling out several causes of metal contamination that were already reported in literature, a new theory for...
journal article 2018
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Storm, A.J. (author), Chen, J.H. (author), Zandbergen, H.W. (author), Dekker, C. (author)
journal article 2005
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Schoonman, J. (author), Dekker, J.P. (author), Broers, J.W. (author), Kiwiet, N.J. (author)
journal article 1991
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De Vlaminck, I. (author), Vidic, I. (author), Van Loenhout, M.T.J. (author), Kanaar, R. (author), Lebbink, J.H.G. (author), Dekker, C. (author)
All cellular single-stranded (ss) DNA is rapidly bound and stabilized by single stranded DNA-binding proteins (SSBs). Replication protein A, the main eukaryotic SSB, is able to unwind double-stranded (ds) DNA by binding and stabilizing transiently forming bubbles of ssDNA. Here, we study the dynamics of human RPA (hRPA) activity on topologically...
journal article 2010
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Lipfert, J. (author), Kerssemakers, J.J.W. (author), Rojer, M. (author), Dekker, N.H. (author)
The double helical nature of DNA links many cellular processes such as DNA replication, transcription, and repair to rotational motion and the accumulation of torsional strain. Magnetic tweezers (MTs) are a single-molecule technique that enables the application of precisely calibrated stretching forces to nucleic acid tethers and to control...
journal article 2011
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Dekker, M. (author), Tzand, I. (author), Schram, J. (author), Schoonman, J. (author)
journal article 1989
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Qu, Z. (author), Aravind, P.V. (author), Ye, H. (author), Dekker, N.J.J. (author), Woudstra, N. (author), Verkooijen, A.H.M. (author)
journal article 2009
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Vlijm, R. (author), Lee, M. (author), Lipfert, J. (author), Lusser, A. (author), Dekker, C. (author), Dekker, N.H. (author)
DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molecules, we monitor the real...
journal article 2015
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Gaio, N. (author), van Meer, B. (author), Quiros Solano, W.F. (author), Bergers, L. (author), van de Stolpe, A (author), Mummery, CL (author), Sarro, P.M. (author), Dekker, R. (author)
Organ-on-Chips (OOCs) are micro-fabricated devices which are used to culture cells in order to mimic functional units of human organs. The devices are designed to simulate the physiological environment of tissues in vivo. Cells in some types of OOCs can be stimulated in situ by electrical and/or mechanical actuators. These actuations can mimic...
journal article 2016
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Van der Heyden, F.H.J. (author), Stein, D. (author), Dekker, C. (author)
journal article 2005
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Stein, D. (author), Kruithof, M. (author), Dekker, C. (author)
journal article 2004
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Qu, Z. (author), Aravind, P.V. (author), Ye, H. (author), Dekker, N.J.J. (author), Woudstra, N. (author), Verkooijen, A.H.M. (author)
This paper presents a three-dimensional model of an anode-supported planar SOFC with corrugated bipolar plates serving as gas channels and current collector above the active area of the cell, based on the direct internal reforming reaction of methane and the electrochemical reaction of hydrogen. A co-flow system with gas mixture of methane,...
journal article 2009
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Dekker, E. (author)
journal article 1998
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Van der Heijden, T. (author), Seidel, R. (author), Modesti, M. (author), Kanaar, R. (author), Wyman, C. (author), Dekker, C. (author)
The human DNA repair protein RAD51 is the crucial component of helical nucleoprotein filaments that drive homologous recombination. The molecular mechanistic details of how this structure facilitates the requisite DNA strand rearrangements are not known but must involve dynamic interactions between RAD51 and DNA. Here, we report the real-time...
journal article 2007
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Van Oene, M.M. (author), Dickinson, L.E. (author), Pedaci, F. (author), Köber, M. (author), Dulin, D. (author), Lipfert, J. (author), Dekker, N.H. (author)
Superparamagnetic beads are widely used in biochemistry and single-molecule biophysics, but the nature of the anisotropy that enables the application of torques remains controversial. To quantitatively investigate the torques experienced by superparamagnetic particles, we use a biological motor to rotate beads in a magnetic field and demonstrate...
journal article 2015
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Nakanishi, T. (author), Bachtold, A. (author), Dekker, C. (author)
journal article 2002
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