Simulation of medium to long-term dune evoloution with interacting marine and aeolian sediment transport processes

In recent years, dune-in-front-of-dike projects have been carried out at several locations, e.g. at Raversijde and Oosteroever in Belgium and the Hondsbossche dunes in the Netherlands. In the near future, many coastal defence systems require reinforcement to adapt to rising sea levels, and often, natural values along the coasts may also be...

Modelling of annual sand transports at the Dutch lower shoreface

Dutch coastal policy aims for a safe, economically strong and attractive coast. This is achieved by maintaining the part of the coast that support these functions; the coastal foundation. The coastal foundation is maintained by means of sand nourishments. Up to now, it has been assumed that net transports across the coastal foundation's...

Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine

Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading...

Design and evaluation of a personal robot playing a self-management education game with children with diabetes type 1

Objective To assess the effects of a personal robot, providing diabetes self-management education in a clinical setting on the pleasure, engagement and motivation to play a diabetes quiz of children (7–12) with type 1 diabetes mellitus (T1DM), and on their acquisition of knowledge about their illness. Methods Children with T1DM (N = 27)...