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de Vries, N.L. (author), Van Unen, Vincent (author), Ijsselsteijn, Marieke E. (author), Abdelaal, T.R.M. (author), Van Der Breggen, Ruud (author), Farina Sarasqueta, Arantza (author), Mahfouz, A.M.E.T.A. (author), Peeters, Koen C.M.J. (author), Höllt, T. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author), De Miranda, Noel F.C.C. (author)Objective: A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of...journal article 2019
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Koppens, Martijn A.J. (author), Bounova, Gergana (author), Cornelissen-Steijger, Paulien (author), de Vries, Nienke (author), Sansom, Owen J. (author), Wessels, L.F.A. (author), van Lohuizen, Maarten (author)EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light. To determine whether colorectal cancer cells respond to EZH2 inhibition and to explore which factors influence the degree of response...journal article 2016