Sensitivity of dose-volume indices to computation settings in high-dose-rate prostate brachytherapy treatment plan evaluation

Purpose: To investigate the variation in computed dose-volume (DV) indices for high-dose-rate (HDR) prostate brachytherapy that can result from typical differences in computation settings in treatment planning systems (TPSs). Methods: Five factors were taken into account: number of dose-calculation points, radioactive source description,...

Symbolic regression and feature construction with GP-GOMEA applied to radiotherapy dose reconstruction of childhood cancer survivors

The recently introduced Gene-pool Optimal Mixing Evolutionary Algorithm for Genetic Programming (GP-GOMEA) has been shown to find much smaller solutions of equally high quality compared to other state-of-the-art GP approaches. This is an interesting aspect as small solutions better enable human interpretation. In this paper, an adaptation of...

Learning to Associate Distances with Historical Patient Data to Enable Fine-grained Studying of Late Adverse Effects of Paediatric Radiotherapy: Data, Methodology, and First Results