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Devia Pinzon, C.A. (author), Giordano, G. (author)We propose an agent-based opinion formation model characterised by a two-fold novelty. First, we realistically assume that each agent cannot measure the opinion of its neighbours about a given statement with infinite resolution and accuracy, and hence it can only perceive the opinion of others as agreeing much more, or more, or comparably, or...journal article 2023
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Devia Pinzon, C.A. (author), Giordano, G. (author)When agent-based models are developed to capture opinion formation in large-scale populations, the opinion update equations often need to embed several complex psychological traits. The resulting models are more realistic, but also challenging to assess analytically, and hence numerical analysis techniques have an increasing importance in...journal article 2023
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de Jong, M.N. (author), Campana, Francesca Cala (author), Li, Pengfei (author), Pan, Qiuwei (author), Giordano, G. (author)In 2022, worldwide mpox outbreaks have called attention to mpox virus infection and treatment opportunities using the drugs cidofovir and tecovirimat, which target different stages of in-host viral proliferation, respectively production and shedding. We propose a new model of in-host viral infection dynamics that distinguishes between the two...journal article 2023
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Devia Pinzon, C.A. (author), Giordano, G. (author)Comparing model predictions with real data is crucial to improve and validate a model. For opinion formation models, validation based on real data is uncommon and difficult to obtain, also due to the lack of systematic approaches for a meaningful comparison. We introduce a framework to assess opinion formation models, which can be used to...journal article 2022
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Blanchini, Franco (author), Devia Pinzon, C.A. (author), Giordano, G. (author), Pesenti, Raffaele (author), Rosset, Francesca (author)We proposed network-decentralized control strategies, in which each actuator can exclusively rely on local information, without knowing the network topology and the external input, ensuring that the flow asymptotically converges to the optimal one with respect to the p -norm. For 1 < p < ∞ , the flow converges to a unique constant...journal article 2022
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Devia Pinzon, C.A. (author), Giordano, G. (author)We study dynamic networks described by a directed graph where the nodes are associated with MIMO systems with transfer-function matrix F(s), representing individual dynamic units, and the arcs are associated with MIMO systems with transfer-function matrix G(s), accounting for the dynamic interactions among the units. In the nominal case, we...journal article 2021
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Topputo, Francesco (author), Merisio, G. (author), Giordano, G. (author), Franzese, V (author), Cervone, A. (author), Speretta, S. (author), Menicucci, A. (author), Bertels, E. (author), Thorvaldsen, a. (author)The Lunar Meteoroid Impact Observer (LUMIO) is a mission designed to observe, quantify, and characterize the impacts of meteoroids on the lunar far side and, therefore, complement in both space and time the observations currently taken from Earth. While Earth-based lunar observations are restricted by weather, geometric and illumination...conference paper 2021
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Devia Pinzon, C.A. (author), Giordano, G. (author)We give a sufficient and a necessary condition for the topology-independent robust stability of networked systems formed by uncertain MIMO systems. Both conditions involve constants associated with the nominal node dynamics and arc interconnection matrices, the uncertainty bounds, and the maximum connectivity degree of the network; they are...journal article 2021
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Burlando, Bruno (author), Milanese, Marco (author), Giordano, G. (author), Bonifacino, Tiziana (author), Ravera, Silvia (author), Blanchini, Franco (author), Bonanno, Giambattista (author)Amyotrophic lateral sclerosis (ALS) is a poor-prognosis disease with puzzling pathogenesis and inconclusive treatments. We develop a mathematical model of ALS based on a system of interactive feedback loops, focusing on the mutant SOD1<sup>G93A</sup> mouse. Misfolded mutant SOD1 aggregates in motor neuron (MN) mitochondria and triggers a...journal article 2020
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Blanchini, Franco (author), Chesi, Graziano (author), Colaneri, Patrizio (author), Giordano, G. (author)In this letter we show how the problem of assessing structural local stability of BDC-decomposable systems, left open in recent literature, can be solved via convex optimisation. First we give a simple test, based on a sufficient condition, that requires checking the strict co-positivity of a multivariate polynomial. Then we provide a...journal article 2020
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Samaniego, Christian Cuba (author), Giordano, G. (author), Franco, Elisa (author)An important challenge in synthetic biology is the construction of periodic circuits with tunable and predictable period. We propose a general architecture, based on the use of recombinase proteins and negative feedback, to build a molecular device for periodic switching between two distinct regimes; the switching rule depends on known...journal article 2020
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Blanchini, Franco (author), Giordano, G. (author)In biochemical networks, the steady-state input-output influence is the sign of the output steady-state variation due to a persistent positive input perturbation; if the sign does not depend on the value of the strictly positive system parameters, the influence is structural. As recently shown for small perturbations, when the linearized...journal article 2019
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- Giordano, G. (author) contribution to periodical 2019
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Devia Pinzon, C.A. (author), Giordano, G. (author)We consider a multi-compartment evolutionary model representing growth, mutation and migration of cancer cells, as well as the effect of drugs, and we design optimal switching targeted cancer therapies where a single drug, or suitable drug combination, is given at each time so as to minimise not only the overall tumor size over a finite horizon,...conference paper 2019
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Giordano, G. (author), de Graaf, Lotte (author), Vasilakou, E. (author), Wahl, S.A. (author)We study dynamic metabolic models that describe the cellular responses of microorganisms under changing environmental conditions, such as substrate perturbations. Feast-famine experiments in Escherichia coli show that, despite the enormous extracellular perturbations, important quantities such as the cell energy charge remain practically...conference paper 2019
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Blanchini, Franco (author), Casagrande, Daniele (author), Fabiani, F. (author), Giordano, G. (author), Pesenti, Raffaele (author)This paper proposes a decentralised explicit (closed-form) iterative formula that solves convex programming problems with linear equality constraints and interval bounds on the decision variables. In particular, we consider a team of decision agents, each setting the value of a subset of the variables, and a team of information agents, in...journal article 2019
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Giordano, G. (author), Segata, Michele (author), Blanchini, Franco (author), Lo Cigno, Renato (author)Vehicular networks supporting cooperative driving are among the most interesting and challenging ad-hoc networks. Platooning, or the act of coordinating a set of vehicles through an ad-hoc network, promises to improve traffic safety, and at the same time reduce congestion and pollution. The design of the control system for this application is...journal article 2019
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Blanchini, Franco (author), Casagrande, Daniele (author), Giordano, G. (author), Viaro, Umberto (author)A multi-agent continuous-time nonlinear model of social behaviour allowing for both competition and cooperation is presented and analysed. The state of each agent is represented by its payoff, which the agent aims at maximising. The role of control variables is played by the model parameters, which account for the agents' decisions to either...conference paper 2019
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Cuba Samaniego, Christian (author), Giordano, G. (author), Franco, Elisa (author)Biological systems compute spatial and temporal gradients with a variety of mechanisms, some of which have been shown to include integral feedback. In traditional engineering fields, it is well known that integral components within a negative feedback loop can be used to perform a derivative action. In this paper, we define the concept of a...conference paper 2019
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Giordano, G. (author), Singh, Abhyudai (author), Blanchini, Franco (author)Genetic oscillators have a fundamental role in the regulation not only of intracellular, but also of intercellular functions: for instance, in the segmentation clock, the synchronised oscillation of neighbouring cells generates spatial travelling waves that induce segmentation of precursors of the vertebral column. To investigate this type of...conference paper 2019
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