Searched for: author%3A%22Beekman%2C+F.J.%22
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Cosmi, V. (author), Wang, B. (author), Goorden, M.C. (author), Beekman, F.J. (author)
Background: Gamma camera imaging, including single photon emission computed tomography (SPECT), is crucial for research, diagnostics, and radionuclide therapy. Gamma cameras are predominantly based on arrays of photon multipliers tubes (PMTs) that read out NaI(Tl) scintillation crystals. In this way, standard gamma cameras can localize ɣ-rays...
journal article 2024
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Nguyen, M.P. (author), Arif, M. (author), Oostenrijk, Bart (author), Goorden, M.C. (author), Beekman, F.J. (author)
Microscopic nuclear imaging down to spatial resolutions of a few hundred microns can already be achieved using low-energy gamma emitters (e.g. <sup>125</sup>I, ∼30 keV) and a basic single micro-pinhole gamma camera. This has been applied to in vivo mouse thyroid imaging, for example. For clinically used radionuclides such as <sup>99m</sup>Tc,...
journal article 2023
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Lilius, Tuomas O. (author), Mortensen, Kristian Nygaard (author), Deville, Claire (author), Lohela, Terhi J. (author), Stæger, Frederik Filip (author), Sigurdsson, Björn (author), Rosenholm, Marko (author), Beekman, F.J. (author), Jensen, Andreas I. (author)
Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate...
journal article 2023
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van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, Harrie (author)
Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a...
journal article 2023
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de Vor, Lisanne (author), van Dijk, Bruce (author), van Kessel, Kok (author), Kavanaugh, Jeffrey S. (author), de Haas, Carla (author), Aerts, Piet C. (author), Ramakers, R.M. (author), Beekman, F.J. (author), Weinans, Harrie (author)
Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show...
journal article 2022
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Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C. (author), Beekman, F.J. (author), van den Heuvel, E.J. (author), Ramakers, R.M. (author), Eelkema, R. (author), Denkova, A.G. (author)
A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...
journal article 2022
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Nguyen, M.P. (author), Goorden, M.C. (author), Ramakers, R.M. (author), Beekman, F.J. (author)
The use of multi-pinhole collimation has enabled ultra-high-resolution imaging of SPECT and PET tracers in small animals. Key for obtaining high-quality images is the use of statistical iterative image reconstruction with accurate energy-dependent photon transport modelling through collimator and detector. This can be incorporated in a system...
journal article 2021
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Chen, Y. (author), Goorden, M.C. (author), Beekman, F.J. (author)
SPECT imaging with 123I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (μ-maps) derived from perfectly registered CT scans. Such μ-maps, however, are most...
journal article 2021
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Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....
journal article 2021
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Pouran, Behdad (author), Raoof, Amir (author), de Winter, D. A.Matthijs (author), Arbabi, V. (author), Bleys, Ronald L.A.W. (author), Beekman, F.J. (author), Zadpoor, A.A. (author), Malda, Jos (author), Weinans, Harrie (author)
Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between articular cartilage and subchondral bone. Here, we describe the mechanisms that facilitate transport at the osteochondral...
journal article 2021
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Beekman, F.J. (author), Kamphuis, C. (author), Koustoulidou, S. (author), Ramakers, R.M. (author), Goorden, M.C. (author)
Despite improvements in small animal PET instruments, many tracers cannot be imaged at sufficiently high resolutions due to positron range, while multi-tracer PET is hampered by the fact that all annihilation photons have equal energies. Here we realize multi-isotope and sub-mm resolution PET of isotopes with several mm positron range by...
journal article 2021
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Chen, Y. (author), Goorden, M.C. (author), Beekman, F.J. (author)
In clinical brain SPECT, correction for photon attenuation in the patient is essential to obtain images which provide quantitative information on the regional activity concentration per unit volume (kBq). This correction generally requires an attenuation map (map) denoting the attenuation coefficient at each voxel which is often derived from...
journal article 2021
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Wang, B. (author), Kreuger, R. (author), Huizenga, J. (author), Beekman, F.J. (author), Goorden, M.C. (author)
Photomultiplier tube (PMT)-based scintillation cameras are predominant in molecular imaging but have the drawback that position estimation is severely degraded near the edges (dead edge effect). This leads to sensitivity losses and can cause severe problems in applications like molecular breast imaging and in certain SPECT devices. Using smaller...
journal article 2020
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Nguyen, M.P. (author), Goorden, M.C. (author), Beekman, F.J. (author)
We recently developed a dedicated focusing multi-pinhole collimator for a stationary SPECT system that offers down to 120 m (or 1.7 nL) spatial resolution SPECT images of cryo-cooled tissue samples (EXIRAD-3D). This collimator is suitable for imaging isotopes that are often used in small animal and diagnostic SPECT such as 125I (27 keV),...
journal article 2020
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Nguyen, M.P. (author), Ramakers, R.M. (author), Kamphuis, Chris (author), Koustoulidou, Sofia (author), Goorden, M.C. (author), Beekman, F.J. (author)
Introduction: Autoradiography is an established technique for high-resolution imaging of radiolabelled molecules in biological tissue slices. Unfortunately, creating a 3D image from a set of these 2D images is extremely time-consuming and error-prone. MicroSPECT systems provide such 3D images but have a low resolution. Here we present EXIRAD...
journal article 2020
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...
journal article 2020
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Goorden, M.C. (author), Kamphuis, Chris (author), Ramakers, R.M. (author), Beekman, F.J. (author)
Today, versatile emission computed tomography (VECTor) technology using dedicated high-energy collimation enables simultaneous positron emission tomography (PET) and single photon emission computed tomography (SPECT) down to 0.6 mm and 0.4 mm resolution in mice, respectively. We recently showed that for optimal resolution and quantitative...
journal article 2020
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Chen, Y. (author), Goorden, M.C. (author), Vastenhouw, B. (author), Beekman, F.J. (author)
Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman...
journal article 2020
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Ozsahin, Ilker (author), Chen, Ling (author), Könik, Arda (author), King, Michael A. (author), Beekman, F.J. (author), Mok, Greta S.P. (author)
Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very...
review 2020
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Wang, B. (author), van Roosmalen, J. (author), Kreuger, R. (author), Huizenga, J. (author), Beekman, F.J. (author), Goorden, M.C. (author)
In recent years, breast imaging using radiolabelled molecules has attracted significant interest. Our group has proposed a multi-pinhole molecular breast tomosynthesis (MP-MBT) scanner to obtain 3D functional molecular breast images at high resolutions. After conducting extensive optimisation studies using simulations, we here present a first...
journal article 2020
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